Article
Medicine, Research & Experimental
Kenneth B. Chapman, Matthew A. Spiegel, Noud van Helmond, Kiran V. Patel, Ajax Yang, Tariq A. Yousef, Nataniel Mandelberg, Timothy Deer, Alon Y. Mogilner
Summary: For chronic pain patients who have previously failed to receive persistent benefit from spinal cord stimulation (SCS), dorsal root ganglion stimulation (DRG-S) can be used as a salvage therapy. The study's results demonstrate that DRG-S can significantly decrease pain levels, improve quality of life, and reduce opioid requirements in these patients.
Article
Neurosciences
Danxu Ma, Qian Huang, Xinyan Gao, Neil C. Ford, Ruijuan Guo, Chi Zhang, Shuguang Liu, Shao-Qiu He, Srinivasa N. Raja, Yun Guan
Summary: Drugs targeting the opioid receptor outside the central nervous system have shown promise in treating pain after spinal cord injury. Asimadoline adversely affected behavior in SCI mice, suggesting CNS drug penetration. In contrast, ICI-204448 reduced pain hypersensitivity without side effects, suggesting its potential as a treatment for SCI pain.
Article
Immunology
James M. Nichols, Caitlin Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd
Summary: This study introduces a novel fluorescently labeled perfluorocarbon nanoemulsion for monitoring phagocytic macrophages in diabetic neuropathy. In vitro experiments showed high stability and uptake of the nanoemulsion by macrophages. In vivo tracking revealed distribution to macrophages in tissues, with reduced distribution in Lepr(db/db) mice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Anesthesiology
Zhen Zhang, Bixin Zheng, Shibin Du, Guang Han, Hui Zhao, Shaogen Wu, Shushan Jia, Thomas Bachmann, Alex Bekker, Yuan-Xiang Tao
Summary: The study revealed that eIF4G2 is involved in the genesis of neuropathic pain caused by nerve injury, by regulating the expression of MOR and Kv1.2 in the injured DRG, suggesting it as a potential target for treatment of this disorder.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Neurosciences
Donghang Zhang, Wenling Zhao, Jin Liu, Mengchan Ou, Peng Liang, Jia Li, Yali Chen, Daqing Liao, Siqi Bai, Jiefei Shen, Xiangdong Chen, Han Huang, Cheng Zhou
Summary: NALCN plays a significant role in chronic neuropathic pain, and knockdown of NALCN can significantly alleviate pain-related symptoms.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junxuan Ma, Vaibhav Patil, Abhay Pandit, Leo R. Quinlan, David P. Finn, Sibylle Grad, Mauro Alini, Marianna Peroglio
Summary: This study utilized an in vitro model to evaluate the communication between chronic discogenic back pain and spinal cord glial cells, finding that cytokine treatment induced DRG-mediated microgliosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lequan Wen, Lirui Tang, Mingming Zhang, Congrui Wang, Shujuan Li, Yuqing Wen, Hongcheng Tu, Haokun Tian, Jingyi Wei, Peiwen Liang, Changsen Yang, Guodong Li, Yun Gao
Summary: This study investigated whether gallic acid could alleviate comorbid visceral pain and depression by reducing the expression of the P2X7 receptor. The results demonstrated that gallic acid was able to relieve pain and depression, while also reducing the expressions of the P2X7 receptor and p-ERK1/2. Gallic acid treatment also decreased inflammatory cytokines IL-1 beta and TNF-alpha levels, while increasing IL-10 levels in the serum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yuying Huang, Shao-Rui Chen, Hong Chen, Jing-Jing Zhou, Daozhong Jin, Hui-Lin Pan
Summary: Research shows that theta-burst stimulation (TBS) has an impact on synaptic plasticity and pain in mice, inducing more long-term potentiation (LTP) in spinal cord neurons. Nerve injury increases the prevalence of TBS-induced LTP, and interventions targeting NMDARs or a243-1 can reduce TBS-induced pain hypersensitivity.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Sipin Zhu, Xiaoyong Hu, Samuel Bennett, Yuliang Mai, Jiake Xu
Summary: TAFA4 is a member of the TAFA chemokine like ligand family and involved in the regulation of various biological processes, including chemotaxis and phagocytosis of macrophages. It is predominantly expressed in nociceptors and plays a role in pain perception. TAFA4 mediates the chemoattraction and inflammatory response of macrophages through binding to the receptor FPR1.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Anesthesiology
Cormac F. Mullins, Gaetano Joseph Palumbo, Stephany Harris, Omar Al-Kaisy, Sam Wesley, Thomas Yearwood, Adnan Al-Kaisy
Summary: This retrospective case series analyzed the outcomes of combined DRGS and SCS treatment in patients with neuropathic pain. The results showed that the combined treatment was effective in reducing pain intensity and had sustained analgesic effects.
Article
Neurosciences
Anna Raunio, Ville Kivisto, Mia Kero, Jarno Tuimala, Sara Savola, Minna Oinas, Eloise Kok, Kia Colangelo, Anders Paetau, Tuomo Polvikoski, Pentti J. Tienari, Henri Puttonen, Liisa Myllykangas
Summary: This population-based study analyzes Lewy-related pathology in the spinal cord, dorsal root ganglion, and adrenal gland, providing support for the existence of at least two distinct types of Lewy-related pathology.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qiao Zheng, Jiawei Zhang, Xiaoshuang Zuo, Jiakai Sun, Zhuowen Liang, Xueyu Hu, Zhe Wang, Kun Li, Jiwei Song, Tan Ding, Xuefeng Shen, Yangguang Ma, Penghui Li
Summary: The study showed that PBM could reduce ROS levels in neurons, increase neuronal survival under oxidative stress, and promote neuronal axon regeneration. Additionally, PBM was found to promote CCL2 secretion by DRG under oxidative stress. By constructing a DRG supernatant-M1 macrophage adoptive culture model, it was demonstrated that the supernatant of DRG after PBM intervention could reduce the expression level of iNOS and the secretion of TNF-alpha and IL-1 beta in M1 macrophages, while up-regulating the expression of Arg-1. These effects could be prevented by the addition of neutralizing antibodies of CCL2.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Aidan McGinnis, Ru-Rong Ji
Summary: Preclinical studies have found that glial cells play a crucial role in the development and maintenance of neuropathic pain in conditions such as diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) exhibit similar characteristics and functions in the genesis of neuropathic pain. However, SGCs are not simply peripheral astrocytes and have unique roles and interactions. Recent findings also suggest that SGCs are enriched with proteins related to fatty acid metabolism, which may have implications for novel therapeutic approaches targeting glial cells.
Article
Neurosciences
Qing-Rui Qin, Zhong-Qing Xu, Ting-Ting Liu, Xue-Mei Li, Chun-Yu Qiu, Wang-Ping Hu
Summary: The activation of CCK-8/CCK2R enhances ASIC-mediated electrophysiological activity in DRG neurons and nociception in rats, suggesting that CCK-8/CCK2R could be an important therapeutic target for ASIC-mediated pain.
Article
Chemistry, Multidisciplinary
Andrew J. Carrod, Francesco Graglia, Louise Male, Cecile Le Duff, Peter Simpson, Mohamed Elsherif, Zubair Ahmed, Haider Butt, Guang-Xi Xu, Kenneth Kam-Wing Lo, Paolo Bertoncello, Zoe Pikramenou
Summary: Dual detection systems are beneficial for rapid and accurate data collection in sensing systems and in vitro testing. The newly introduced Ir-III complex with a boronic acid receptor site attached to a 2-phenylpyridine ligand serves as an ideal probe for sensitive detection of monosaccharide binding, showing potential for integration into devices.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Biographical-Item
Neurosciences
Zubair Ahmed, Ann Logan
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Ophthalmology
Inesa Lelyte, Zubair Ahmed, Simon Kaja, Giedrius Kalesnykas
Summary: This systematic review investigated the most useful readouts of STZ-induced DR and found that electroretinography (ERG) represents the most consistent functional readout. However, caution must be used when interpreting these studies due to the high risk of bias.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2022)
Review
Cell Biology
Andrew R. Stevens, Clarissa A. Stickland, Georgia Harris, Zubair Ahmed, Pola Goldberg Oppenheimer, Antonio Belli, David J. Davies
Summary: Traumatic brain injury (TBI) is a global health problem, and there is currently a lack of therapeutics to improve survival and outcomes. Current neuromonitoring methods cannot accurately reflect the complex pathophysiological processes occurring after TBI. Raman spectroscopy (RS) is a powerful optical tool that can provide detailed biochemical data in vivo. This systematic review evaluates the evidence for the use of RS in TBI and highlights its potential in identifying injury severity and metabolic dysfunction.
Review
Neurosciences
Zubair Ahmed
Summary: Traumatic brain injury (TBI) is a major cause of morbidity, disability, and mortality globally. Experimental treatments targeting biochemical and cellular changes after TBI are currently being evaluated in clinical trials, but the results vary. This study aims to identify the drugs currently being evaluated for TBI in clinical trials.
Article
Oncology
Zubair Ahmed, Sharif Alhajlah, Adam M. Thompson, Rebecca J. Fairclough
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Emergency Medicine
Jaden Tollman, Zubair Ahmed
Summary: Ventilation strategies for primary blast lung injury (PBLI) should aim to minimize lung injury by utilizing conventional low tidal volume ventilation, airway pressure release ventilation, and high frequency oscillatory ventilation. Conventional low tidal volume ventilation with variable positive end-expiratory pressure and permissive hypercapnia has shown to reduce inflammation and mortality. Airway pressure release ventilation has the potential to reduce dynamic strain and extravascular lung water while encouraging spontaneous breathing. High frequency oscillatory ventilation is able to effectively avoid lung injury but may not necessarily reduce mortality.
Review
Critical Care Medicine
Andrew Robert Stevens, Mohammed Hadis, Michael Milward, Zubair Ahmed, Antonio Belli, William Palin, David James Davies
Summary: Photobiomodulation (PBM) is a therapeutic modality that has shown promise in improving outcomes in acute traumatic brain injury (TBI), with its antiapoptotic and anti-inflammatory effects. This systematic review provides evidence of the benefits of PBM on functional and histological outcomes of TBI in in vivo mammalian models, supporting its safety and feasibility in acute moderate TBI in human patients.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Oncology
Zubair Ahmed, Richard I. Tuxworth
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthew J. Taylor, Adam M. Thompson, Sharif Alhajlah, Richard Tuxworth, Zubair Ahmed
Summary: DNA double-strand breaks play a crucial role in neurological conditions, and targeting the ATM-Chk2 pathway can slow down neural decline and promote neuroprotection by inhibiting nonhomologous end-joining.
Review
Cell Biology
Farihah Iqbal Khan, Zubair Ahmed
Summary: Spinal cord injury (SCI) is a complex and prolonged injury process that leads to loss of neurological functions. Current treatments are limited and novel treatments targeting ongoing injury processes are needed. In a systematic review of studies, combined tetrahedral framework nucleic acid with neural stem cells and Fortasyn (R) Connect supplementation showed significant improvements in functional recovery and attenuated secondary injury processes.
Article
Computer Science, Artificial Intelligence
Yuanjie Xia, Mohamed Khamis, F. Anibal Fernandez, Hadi Heidari, Haider Butt, Zubair Ahmed, Tim Wilkinson, Rami Ghannam
Summary: Recent advances in microelectronics and nanofabrication on flexible substrates have enabled contact lenses to be used for a range of human-machine interaction applications. A systematic review reveals that smart contact lenses can display information, detect eye movements, restore vision, and detect biomarkers in tear fluid. The study also classifies literature on smart contact lenses and speculates on their challenges and opportunities for HMI, providing guidelines for future design.
IEEE TRANSACTIONS ON HUMAN-MACHINE SYSTEMS
(2023)
Review
Cell Biology
Zunira Areeba Bhuiyan, Oluwasemilore Adebayo, Zubair Ahmed
Summary: This study aimed to explore the efficacy and safety of localised insulin administration on wound healing in non-diabetic adults. The findings showed a significant improvement in wound healing rate in the insulin treated group, but other parameters were not statistically significant. Therefore, larger prospective studies are needed to fully investigate the effects of insulin on different wounds.
WOUND REPAIR AND REGENERATION
(2023)
Review
Medicine, General & Internal
Sheikh Azka Zaheer, Zubair Ahmed
Summary: Carpal tunnel syndrome (CTS) is a common condition that causes numbness and weakness in the hand and arm. Neurodynamic modulation techniques have been used as a non-surgical treatment for CTS, but their effectiveness has been unclear. This systematic review found that neurodynamic techniques significantly reduced symptom severity, pain, and motor latency in CTS patients, while improving nerve conduction velocities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Narek Manukjan, Daria Majcher, Peter Leenders, Florian Caiment, Marcel van Herwijnen, Hubert J. J. Smeets, Ernst Suidgeest, Louise van der Weerd, Tim Vanmierlo, Jacobus F. A. Jansen, Walter H. H. Backes, Robert J. J. van Oostenbrugge, Julie Staals, Daniel Fulton, Zubair Ahmed, W. Matthijs Blankesteijn, Sebastien Foulquier
Summary: Cerebral small vessel disease is characterized by decreased cerebral blood flow and blood-brain barrier impairments, leading to the development of white matter lesions. Cerebral hypoperfusion induces hypoxia and affects the signaling between oligodendrocyte precursor cells and endothelial cells, resulting in blood-brain barrier dysfunction. In this study, a mouse model of cerebral hypoperfusion was used to investigate the role of hypoxia-induced VEGFA expression in the development of white matter lesions. The results suggest that VEGFA upregulation in hypoxic oligodendrocyte precursor cells mediates blood-brain barrier permeability, which is associated with increased VEGFA plasma levels in cerebral small vessel disease patients.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)