Article
Biochemistry & Molecular Biology
Qi-Qi Li, Jia-Ying Li, Ming Zhou, Zheng-Hong Qin, Rui Sheng
Summary: Cerebral ischemia is a disease caused by intracranial artery stenosis or occlusion, leading to ischemic necrosis of brain tissue, where neuroinflammation plays a key role.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Neurosciences
Xin Sui, Hideyuki Yoshioka, Yuichiro Fukumoto, Kazuya Kanemaru, Hiroyuki Kinouchi
Summary: HAX-1 is a mitochondrial protein that plays a neuroprotective role against ischemic neuronal injury, and the downregulation of HAX-1 by NOX2-produced ROS can induce apoptosis after cerebral ischemia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Plant Sciences
Yuli Han, Xuewang Li, Liu Yang, Duoduo Zhang, Lan Li, Xianan Dong, Yan Li, Sen Qun, Weizu Li
Summary: Ginsenoside Rg1 has been shown to have a significant neuroprotective effect in cerebral ischemia-reperfusion injury (CIRI), attenuating neuronal damage by inhibiting oxidative stress, calcium overload, and neuroinflammation.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Duaah Almarzouq, May Al-Maghrebi
Summary: Oxidative stress, inflammation, and germ cell death are characteristic features of testicular ischemia reperfusion injury (tIRI), which can lead to testicular torsion and detorsion. This study investigated the impact of tIRI-activated NADPH oxidase (NOX) on the expression of the NLRP3 inflammasome pathway components. Results showed that tIRI caused spermatogenic damage, oxidative stress, and inflammation, as evidenced by altered antioxidant capacity, enzyme activity, and increased concentrations of inflammatory markers. Additionally, the components of the NLRP3 inflammasome pathway were upregulated during tIRI. Treatment with the NOX-specific inhibitor, apocynin, prevented oxidative stress, inflammation, and NLRP3 inflammasome activation during tIRI.
Article
Plant Sciences
Minzhen Deng, Jingbo Sun, Lilin Peng, Yan Huang, Wen Jiang, Shuang Wu, Lihua Zhou, Sookja Kim Chung, Xiao Cheng
Summary: This study found that scutellarin has antioxidant effects on cerebral ischemic injury, and this effect is related to the regulation of the Aldose reductase (AR) gene. Scutellarin treatment can improve neurological function deficits and brain damage in an ischemic stroke model, and reduce the expression of oxidation-related products. In addition, the therapeutic effect of scutellarin on reducing cerebral infarction area and neurological function deficits is abolished in AR knockout mice, indicating that scutellarin's effect on cerebral ischemic injury is through regulating the AR gene.
Article
Clinical Neurology
Xiaoyu Wu, Danfei Ji, Zefan Wang, Wenhua Yu, Quan Du, Wei Hu, Yongke Zheng, Xiaoqiao Dong, Fanghui Chen
Summary: In this study, serum levels of NADPH oxidase 2 (NOX2) were found to be highly expressed in injured brain tissues of patients with aneurysmal subarachnoid hemorrhage (aSAH). Serum NOX2 levels were correlated with disease severity, delayed cerebral ischemia (DCI), and prognosis after aSAH.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Leticia Guadalupe Fragoso-Morales, Jose Correa-Basurto, Martha Cecilia Rosales-Hernandez
Summary: Alzheimer's disease is a major human dementia characterized by memory loss associated with oxidative stress in brain cells. Overexpression of NADPH oxidase in AD leads to the production of large amounts of reactive oxygen species, damaging brain cells and vasculature, making it a potential therapeutic target for AD.
Editorial Material
Plant Sciences
Pooja Singh, Vipul Mishra, Durgesh Kumar Tripathi, Francisco J. Corpas, Vijay Pratap Singh
Summary: Reactive oxygen species (ROS) play a crucial role in plant development and stress response. Recent research by Li et al. showed that ROS production is regulated by receptor-like cytoplasmic kinase (RLCK)-mediated phosphorylation of respiratory burst oxidase homolog D (RBOHD), which in turn modulates plant immunity and enhances biotic stress tolerance.
TRENDS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Article
Endocrinology & Metabolism
Alessio Alfieri, Juraj Koudelka, Mosi Li, Sanny Scheffer, Jessica Duncombe, Andrea Caporali, Rajesh N. Kalaria, Colin Smith, Ajay M. Shah, Karen Horsburgh
Summary: Chronic microvascular inflammation and oxidative stress are important mechanisms underlying white matter disease and vascular cognitive impairment (VCI). Nox2 plays a critical role, and its genetic deletion can protect against white matter pathology and cognitive impairment. This study has clinical implications for the treatment of vascular diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Medicine, Research & Experimental
Natalia K. S. Lima, Wilka R. A. Farias, Marry A. S. Cirilo, Angelica G. Oliveira, Juliane S. Farias, Regina S. Aires, Humberto Muzi-Filho, Ana D. O. Paixao, Leucio D. Vieira
Summary: Acute renal injury induced by ischemia-reperfusion may lead to changes in proximal tubule ATPases and RAAS components, which are associated with renal Na+ retention and hypertension. NADPH oxidase plays a key role in these alterations.
Review
Genetics & Heredity
Nuha Milad Ashtiwi, Demba Sarr, Balazs Rada
Summary: DUOX1, a member of NADPH oxidases, plays important physiological, immunological, and biochemical roles in the body. While predominantly expressed in epithelial lineages, DUOX1 is often silenced in epithelial-derived cancers due to epigenetic mechanisms. Studies suggest a causative relationship between DUOX1 function and disease pathophysiology.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Hassan Dakik, Maya El Dor, Joan Leclerc, Farah Kouzi, Ali Nehme, Margaux Deynoux, Christelle Debeissat, Georges Khamis, Elfi Ducrocq, Aida Ibrik, Marie-Jose Stasia, Houssam Raad, Hamid Reza Rezvani, Fabrice Gouilleux, Kazem Zibara, Olivier Herault, Frederic Mazurier
Summary: The study found that NOX2 is widely expressed in AML blasts, especially in certain types of cells, but less expressed in stem cells and relapsed AML. Endogenous NOX activity could not be detected without stimulation. Although CYBB knockdown affected NOX2 activity, it did not impact the proliferation and differentiation of THP-1 and HL-60 cells.
Article
Agriculture, Multidisciplinary
Lishan Yao, Fangfang Ban, Shurui Peng, Dan Xu, Hongbo Li, Haizhen Mo, Liangbin Hu, Xiaohui Zhou
Summary: This study revealed an unexpected inhibitory role of ferrous sulfate on Aspergillus flavus and identified a pathway of exogenous Fe2+-triggered conidial ferroptosis mediated by NoxA of the fungus. This finding provides a potential alternative strategy to control this pathogen.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Sichao Guo, Fengwu Li, Melissa Wills, James Yip, Alexandra Wehbe, Changya Peng, Xiaokun Geng, Yuchuan Ding
Summary: The study demonstrates that C+P treatment reduces neurologic damage and inhibits oxidative stress in ischemic stroke, suggesting its potential as an antioxidant.
MEDIATORS OF INFLAMMATION
(2022)
Article
Agriculture, Multidisciplinary
Kazutoshi Murotomi, Aya Umeno, Mayu Yasunaga, Mototada Shichiri, Noriko Ishida, Taisuke Koike, Toshiki Matsuo, Hiroko Abe, Yasukazu Yoshida, Yoshihiro Nakajima
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2015)
Article
Biotechnology & Applied Microbiology
Mayu Yasunaga, Kazutoshi Murotomi, Hiroko Abe, Tomomi Yamazaki, Shigeaki Nishii, Tetsuya Ohbayashi, Mitsuo Oshimura, Takako Noguchi, Kazuki Niwa, Yoshihiro Ohmiya, Yoshihiro Nakajima
JOURNAL OF BIOTECHNOLOGY
(2015)
Article
Chemistry, Applied
Aya Umeno, Mizuki Takashima, Kazutoshi Murotomi, Yoshihiro Nakajima, Taisuke Koike, Toshiki Matsuo, Yasukazu Yoshida
JOURNAL OF OLEO SCIENCE
(2015)
Review
Chemistry, Applied
Yasukazu Yoshida, Aya Umeno, Yoko Akazawa, Mototada Shichiri, Kazutoshi Murotomi, Masanori Hone
JOURNAL OF OLEO SCIENCE
(2015)
Review
Biochemistry & Molecular Biology
Aya Umeno, Masanori Horie, Kazutoshi Murotomi, Yoshihiro Nakajima, Yasukazu Yoshida
Article
Multidisciplinary Sciences
Kazutoshi Murotomi, Shigeyuki Arai, Satoko Uchida, Shin Endo, Hitoshi Mitsuzumi, Yosuke Tabei, Yasukazu Yoshida, Yoshihiro Nakajima
SCIENTIFIC REPORTS
(2016)
Article
Food Science & Technology
Yosuke Tabei, Kazutoshi Murotomi, Aya Umeno, Masanori Horie, Yoshio Tsujino, Bumbu Masutani, Yasukazu Yoshida, Yoshihiro Nakajima
FOOD AND CHEMICAL TOXICOLOGY
(2017)
Article
Chemistry, Analytical
Katsuhiro Uno, Kazutoshi Murotomi, Yasuhiro Kazuki, Mitsuo Oshimura, Yoshihiro Nakajima
Article
Biochemistry & Molecular Biology
K. Murotomi, A. Umeno, M. Yasunaga, M. Shichiri, N. Ishida, H. Abe, Y. Yoshida, Y. Nakajima
FREE RADICAL RESEARCH
(2015)
Article
Food Science & Technology
Kazutoshi Murotomi, Shigeyuki Arai, Aki Suyama, Akira Harashima, Yoshihiro Nakajima
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Biochemistry & Molecular Biology
Aya Umeno, Mami Sakashita, Sakiko Sugino, Kazutoshi Murotomi, Kentaro Tomii, Yuko Tsuchiya, Kazuhiko Yamasaki, Masanori Horie, Kentaro Takahara, Yasukazu Yoshida, Tsugumi Okuzawa, Naoki Morita
BIOSCIENCE REPORTS
(2020)
Article
Medicine, Research & Experimental
Kazutoshi Murotomi, Hirosuke Tawara, Mitsuko Sutoh, Mayu Yasunaga
Summary: Non-alcoholic steatohepatitis (NASH) is influenced by the complex interaction between the liver and other organs. This study found that iron-accumulating splenocytes can induce inflammation and exacerbate NASH. Therefore, the regulation of iron metabolism in the spleen is crucial for the development of novel therapeutic targets for NASH.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yoshiki Hayashi, Soshiro Kashio, Kazutoshi Murotomi, Shinjiro Hino, Woojin Kang, Kenji Miyado, Mitsuyoshi Nakao, Masayuki Miura, Satoru Kobayashi, Masakazu Namihira
Summary: Tissue aging is a major factor contributing to disabilities and shortened lifespan. The mechanism of tissue aging is not completely understood, but this study suggests that the biosynthesis of S-adenosyl-methionine (SAM) can accelerate aging-related defects during Drosophila oogenesis. The study also reveals an aging-related increase in SAM levels in mouse reproductive tissue and the brain.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Mayu Yasunaga, Fumiko Kobayashi, Yu Sogo, Kazutoshi Murotomi, Motohiro Hirose, Yuki Hara, Masashi Yamazaki, Atsuo Ito
Summary: This study demonstrated the enhancing effects of low-molecular-weight heparin (LMWH) incorporated into fibroblast growth factor-2 (FGF-2)-calcium phosphate composite layers on the biological activity of FGF-2 in vitro. The presence of LMWH increased the stability and amount of FGF-2 in the composite layers, leading to enhanced mitogenic and endothelial tube-forming activities, as well as osteogenic differentiation gene expression. These findings suggest that the LMWH-FGF-2-calcium phosphate composite layer holds promise as a coating for orthopedic and dental implants.
ACTA BIOMATERIALIA
(2022)
Article
Veterinary Sciences
Masanori Horie, Takamasa Miura, Satomi Hirakata, Akira Hosoyama, Sakiko Sugino, Aya Umeno, Kazutoshi Murotomi, Yasukazu Yoshida, Taisuke Koike
EXPERIMENTAL ANIMALS
(2017)