Article
Biochemistry & Molecular Biology
Mohammad-Masoud Zavvarian, Cindy Zhou, Sabah Kahnemuyipour, James Hong, Michael G. Fehlings
Summary: This study identified differential gene expression patterns in response to spinal cord injury across different species, highlighting commonalities in extracellular matrix components but variations in MAPK signaling. Conservation and interaction analyses revealed well-preserved sequences for potential therapeutic targets. Immunohistochemical staining validated expression patterns, suggesting promising translational relevance for SCI therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Y. T. Zang, M. J. Bai, L. Wang, M. X. Zhang, L. Li
Summary: This study aimed to systematically review and quantify the association between acupuncture and pelvic floor muscle exercise and bladder dysfunction rehabilitation in individuals with spinal nerve injury. Through literature search and meta-analysis, the results showed that acupuncture and pelvic floor muscle exercise have significant effects on the treatment of bladder dysfunction after spinal nerve injury.
Article
Developmental Biology
Abdulmajeed Fahad Alrefaei, Andrea E. Munsterberg, Grant N. Wheeler
Summary: Frizzled receptors, transducing signals through Wnts, are crucial for neural tube development. Specific expression profiles of FZD receptors offer basis for future functional studies, showing interactions of Wnts-FZDs during spinal cord neurogenesis.
GENE EXPRESSION PATTERNS
(2021)
Article
Developmental Biology
Craig T. Jacobs, Aarti Kejriwal, Katrinka M. Kocha, Kevin Y. Jin, Peng Huang
Summary: During neural development, the duration of Notch signaling plays a crucial role in cell fate specification. Additionally, the Notch ligand Jag2b is important for maintaining neural progenitor cells.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Behavioral Sciences
Ziyin Han, Zufang Mou, Yulong Jing, Rong Jiang, Tao Sun
Summary: This study elucidates that EMX1 functions as a tumor inhibitor in SCG by suppressing WASF2-dependent activation of the Wnt/beta-catenin axis.
BRAIN AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Gokhan Cucun, Melina Koehler, Sabrina Pfitsch, Sepand Rastegar
Summary: The vertebrate nervous system consists of diverse neurons and synaptic connections. The spinal cord is an ideal model for studying neuronal diversity due to its simple network and conserved molecular processes. This review focuses on two different progenitor domains in the zebrafish spinal cord: the lateral floor plate (LFP) and the p2 progenitor domain. These domains generate different types of neurons and subtypes through specific signaling pathways and transcription factors.
Article
Neurosciences
Alexandre Dumoulin, Nikole R. Zuniga, Esther T. Stoeckli
Summary: Understanding the behavior of growth cones during neural circuit formation is crucial, but studying the molecular mechanisms and neural environment involved can be challenging. A novel ex vivo method allows for real-time observation and analysis of individual growth cones during navigation, providing insights into their behaviors and dynamics.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Anesthesiology
Elizabeth K. Serafin, Aditi Paranjpe, Chelsie L. Brewer, Mark L. Baccei
Summary: Neonatal tissue damage may have long-term effects on nociceptive processing in the central nervous system, with pDyn neurons in the spinal dorsal horn playing a crucial role. Research identified gene expression changes in adult pDyn neurons following neonatal tissue injury, with genes related to cellular stress response being highlighted, suggesting that posttranscriptional regulation may play a key role in the activation of nociceptive circuits by early-life injury.
Article
Gastroenterology & Hepatology
Mark M. Aloysius, Mark A. Korsten, Miroslav Radulovic, Kamaldeep Singh, Brian L. Lyons, Tradd Cummings, Joshua Hobson, Sandeep Kahal, Ann M. Spungen, William A. Bauman
Summary: This study investigated the effect of biofeedback on anorectal manometric parameters in patients with incomplete spinal cord injury. The results showed that the biofeedback training program did not improve these parameters. This suggests that the utility of biofeedback is limited in improving anorectal function in patients with incomplete spinal cord injury.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Developmental Biology
Samantha J. England, Amber K. Rusnock, Amra Mujcic, Angelica Kowalchuk, Sarah de Jager, William C. Hilinski, Jose L. Juarez-Morales, Matthew E. Smith, Ginny Grieb, Santanu Banerjee, Katharine E. Lewis
Summary: This study reveals two molecularly distinct subsets of zebrafish V0v spinal interneurons, as well as multiple transcriptional regulators that may act downstream of Evx1/2 to specify the essential functional characteristics of these cells. The findings suggest that in the absence of Evx1 and Evx2, V0v spinal interneurons may change their neurotransmitter phenotypes and express markers of distinct inhibitory spinal interneurons or motoneurons.
NEURAL DEVELOPMENT
(2023)
Article
Rehabilitation
Maya Sato-Klemm, Alison M. M. Williams, W. Ben Mortenson, Tania Lam
Summary: The study assesses the knowledge, attitudes, and practices related to pelvic floor muscle training (PFMT) among individuals with spinal cord injury (SCI). The findings indicate that while there is awareness and positive attitudes toward PFMT, the practice rate is low, and there are notable differences in attitudes based on sex and level of paralysis.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Review
Developmental Biology
Takuma Shinozuka, Shinji Takada
Summary: The roof plate of the spinal cord plays a crucial role in the development of neural crest cells and the dorsal spinal cord. It also contributes to the morphological changes of the spinal cord, including the formation of the central canal. Understanding the underlying mechanisms of these processes, such as the stretching of roof plate cells and activation of Wnt/beta-catenin signaling, can provide insights into neural progenitor cell proliferation in the spinal cord.
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shay Geula, Sharon Moshitch-Moshkovitz, Dan Dominissini, Abed AlFatah Mansour, Nitzan Kol, Mali Salmon-Divon, Vera Hershkovitz, Eyal Peer, Nofar Mor, Yair S. Manor, Moshe Shay Ben-Haim, Eran Eyal, Sharon Yunger, Yishay Pinto, Diego Adhemar Jaitin, Sergey Viukov, Yoach Rais, Vladislav Krupalnik, Elad Chomsky, Mirie Zerbib, Itay Maza, Yoav Rechavi, Rada Massarwa, Suhair Hanna, Ido Amit, Erez Y. Levanon, Ninette Amariglio, Noam Stern-Ginossar, Noa Novershtern, Gideon Rechavi, Jacob H. Hanna
Article
Biotechnology & Applied Microbiology
Abed AlFatah Mansour, J. Tiago Goncalves, Cooper W. Bloyd, Hao Li, Sarah Fernandes, Daphne Quang, Stephen Johnston, Sarah L. Parylak, Xin Jin, Fred H. Gage
NATURE BIOTECHNOLOGY
(2018)
Article
Developmental Biology
Abed AlFatah Mansour, Sophie Khazanov-Zisman, Yaara Netser, Avihu Klar, Nissim Ben-Arie
Editorial Material
Biochemistry & Molecular Biology
Abed AlFatah Mansour, Jacob H. Hanna
Article
Multidisciplinary Sciences
Abed AlFatah Mansour, Ohad Gafni, Leehee Weinberger, Asaf Zviran, Muneef Ayyash, Yoach Rais, Vladislav Krupalnik, Mirie Zerbib, Daniela Amann-Zalcenstein, Itay Maza, Shay Geula, Sergey Viukov, Liad Holtzman, Ariel Pribluda, Eli Canaani, Shirley Horn-Saban, Ido Amit, Noa Novershtern, Jacob H. Hanna
Article
Multidisciplinary Sciences
Yoach Rais, Asaf Zviran, Shay Geula, Ohad Gafni, Elad Chomsky, Sergey Viukov, Abed AlFatah Mansour, Inbal Caspi, Vladislav Krupalnik, Mirie Zerbib, Itay Maza, Nofar Mor, Dror Baran, Leehee Weinberger, Diego A. Jaitin, David Lara-Astiaso, Ronnie Blecher-Gonen, Zohar Shipony, Zohar Mukamel, Tzachi Hagai, Shlomit Gilad, Daniela Amann-Zalcenstein, Amos Tanay, Ido Amit, Noa Novershtern, Jacob H. Hanna
Article
Multidisciplinary Sciences
Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour, Yair S. Manor, Elad Chomsky, Dalit Ben-Yosef, Yael Kalma, Sergey Viukov, Itay Maza, Asaf Zviran, Yoach Rais, Zohar Shipony, Zohar Mukamel, Vladislav Krupalnik, Mirie Zerbib, Shay Geula, Inbal Caspi, Dan Schneir, Tamar Shwartz, Shlomit Gilad, Daniela Amann-Zalcenstein, Sima Benjamin, Ido Amit, Amos Tanay, Rada Massarwa, Noa Novershtern, Jacob H. Hanna
Article
Neurosciences
Simon T. Schafer, Apua C. M. Paquola, Shani Stern, David Gosselin, Manching Ku, Monique Pena, Thomas J. M. Kuret, Marvin Liyanage, Abed AlFatah Mansour, Baptiste N. Jaeger, Maria C. Marchetto, Christopher K. Glass, Jerome Mertens, Fred H. Gage
NATURE NEUROSCIENCE
(2019)
Review
Cell Biology
Abed AlFatah Mansour, Simon T. Schafer, Fred H. Gage
Summary: Brain organoids, derived from pluripotent stem cells through self-organization, are three-dimensional neural aggregates that mimic certain brain regions. They present an exciting area of research for studying human brain development, function, and dysfunction in new ways. Strategies including complementing neuroectodermal models with non-neuronal cell types, as well as transplantation approaches for higher cellular complexity and long-term survival, have been discussed in recent discoveries.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Shani Stern, Shong Lau, Andreea Manole, Idan Rosh, Menachem Mendel Percia, Ran Ben Ezer, Maxim N. Shokhirev, Fan Qiu, Simon Schafer, Abed AlFatah Mansour, Kile P. Mangan, Tchelet Stern, Polina Ofer, Yam Stern, Ana Paula Diniz Mendes, Jose Djamus, Lynne Randolph Moore, Ritu Nayak, Sapir Havusha Laufer, Aidan Aicher, Amanda Rhee, Thomas L. Wong, Thao Nguyen, Sara B. Linker, Beate Winner, Beatriz C. Freitas, Eugenia Jones, Irit Sagi, Cedric Bardy, Alexis Brice, Juergen Winkler, Maria C. Marchetto, Fred H. Gage
Summary: The study identified a common neurophysiological phenotype in neurons derived from Parkinson's disease (PD) patients, which exhibited severe reduction in the rate of synaptic currents. It also revealed changes in gene expression and affected pathways in relation to synaptic mechanisms. These findings suggest that the pathogenesis of synapses is a general phenotype in PD and emphasize the involvement of the tetra-partite synapse in PD pathophysiology.
NPJ PARKINSONS DISEASE
(2022)