Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Biochemistry & Molecular Biology
Anna Maria Lavezzi
Summary: This study found anatomical and functional degenerations of dopaminergic neurons in most SIDS cases, indicating that dopamine depletion, which is already known to be linked especially to Parkinson's disease, is strongly involved in the pathogenesis of SIDS.
Article
Neurosciences
Douglas R. Miller, Dylan T. Guenther, Andrew P. Maurer, Carissa A. Hansen, Andrew Zalesky, Habibeh Khoshbouei
Summary: The dopaminergic neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) exhibit regional differences in network connectivity, with a higher incidence of hub-like neurons in the VTA compared to the SNC. Neuronal loss in the SNC increases network clustering, whereas the VTA compensates by decreasing network clustering due to a larger number of hub-neurons. Network properties in these dopaminergic brain regions can be regulated via a dopamine transporter mechanism, demonstrating novel regulatory mechanisms of functional network topology.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Takuya Hikima, Christian R. Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E. Rice
Summary: Research suggests that somatodendritic dopamine release in the substantia nigra pars compacta autoinhibits the neuron that releases it.
Article
Chemistry, Medicinal
Michela Ferrucci, Francesca Biagioni, Carla L. Busceti, Chiara Vidoni, Roberta Castino, Ciro Isidoro, Larisa Ryskalin, Alessandro Frati, Stefano Puglisi-Allegra, Francesco Fornai
Summary: The study investigates the role of autophagy in METH-induced toxicity of dopamine neurons, revealing that ongoing autophagy protects dopamine neurons and determines the refractoriness of cell bodies to METH-induced toxicity.
Article
Clinical Neurology
Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Andrea Pilotto, Claudio Liguori, Agostino Chiaravalloti, Valentina Garibotto, Giovanni Battista Frisoni, Marcello D'Amelio, Barbara Paghera, Orazio Schillaci, Nicola Mercuri, Alessandro Padovani, Daniela Perani
Summary: The study found significant reductions in [123I]FP-CIT binding in both AD-MCI and AD-D patients compared to controls, particularly in the major targets of the ventrotegmental-mesocorticolimbic pathway. Molecular connectivity assessment revealed a widespread loss of inter-connections among subcortical and cortical targets of the mesocorticolimbic network only, highlighting potential therapeutic strategies for AD.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Laurel S. Morris, Marishka Mehta, Christopher Ahn, Morgan Corniquel, Gaurav Verma, Bradley Delman, Patrick R. Hof, Yael Jacob, Priti Balchandani, James W. Murrough
Summary: This study investigates the anatomy of the ventral tegmental area (VTA) using ultra-high field MRI and machine learning techniques. The results show that individuals with depression and anxiety disorders have larger VTA volumes but lower signal intensity, indicating reduced structural integrity of the dopaminergic VTA. Furthermore, VTA integrity is associated with extrinsic motivation cognitive measures.
Article
Multidisciplinary Sciences
Wen-Liang Zhou, Kristen Kim, Farhan Ali, Steven T. Pittenger, Cali A. Calarco, Yann S. Mineur, Charu Ramakrishnan, Karl Deisseroth, Alex C. Kwan, Marina R. Picciotto
Summary: Dopamine signaling from the ventral tegmental area (VTA) is important for reward-related behaviors. This study reveals that neighboring VTA GABAergic neurons project to the ventral pallidum (VP) and their activity correlates with reward size and palatability. Stimulation of this GABA projection enhances the activity of VP neurons involved in seeking reward and improves performance in a cue-reward task.
Article
Neurosciences
Christopher W. Tschumi, Harris E. Blankenship, Ramaswamy Sharma, William B. Lynch, Michael J. Beckstead
Summary: In this study, it was discovered that the release of neurotensin by dopamine neurons drives signaling between dopamine neurons. This feedforward mechanism may increase the excitability of dopamine neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Patricia Gonzalez-Rodriguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, Jose Lopez-Barneo, Paul T. Schumacker, D. James Surmeier
Summary: Loss of functional mitochondrial complex I in dopaminergic neurons can lead to a shift in metabolism in mice, causing Parkinson's disease-like symptoms. This study challenges the traditional paradigm of Parkinson's disease by showing that dysfunction of mitochondrial complex I alone is sufficient to cause progressive parkinsonism.
Article
Chemistry, Multidisciplinary
Jiang-Peng Fan, Hui-Zhen Geng, Ya-Wei Ji, Tao Jia, Jennifer B. Treweek, An-An Li, Chun-Yi Zhou, Viviana Gradinaru, Cheng Xiao
Summary: Key components in the nigrostriatal DA system exhibit distinct aging patterns and may contribute to age-related alterations in locomotion and coordination.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell & Tissue Engineering
Man Xiong, Yezheng Tao, Qinqin Gao, Ban Feng, Wei Yan, Yingying Zhou, Thomas A. Kotsonis, Tingli Yuan, Zhiwen You, Ziyan Wu, Jiajie Xi, Alexander Haberman, Julia Graham, Jasper Block, Wenhao Zhou, Yuejun Chen, Su-Chun Zhang
Summary: The study demonstrates that human embryonic stem cell-derived neurons have the ability to repair specific circuits and restore functionality in the adult brain, leading to improvements in motor function.
Article
Biology
Sage S. Frehner, Kip T. Dooley, Michelle C. Palumbo, Aaron L. Smith, Mark M. Goodman, Karen L. Bales, Sara M. Freeman
Summary: This study found significantly lower levels of OXTR in females with autism compared to other groups. There were no differences in mRNA levels for either gene across the four groups. These results suggest that dysregulation in OXTR protein translation or increased OXTR internalization/recycling may contribute to the differences in social symptoms seen in females with autism.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ryan J. Post, David A. Bulkin, R. Becket Ebitz, Vladlena Lee, Kasey Han, Melissa R. Warden
Summary: Tonic activity in lateral habenula neurons suppresses engagement in reward-seeking behavior in response to both negative and positive valence factors. This finding is important for understanding the balance between reward pursuit and behavioral regulation.
Article
Cell & Tissue Engineering
Jinghua Piao, Susan Zabierowski, Brittany N. Dubose, Ellen J. Hill, Monalisa Navare, Nidia Claros, Siera Rosen, Kiran Ramnarine, Callie Horn, Craig Fredrickson, Karen Wong, Brent Safford, Sonja Kriks, Abderrahman El Maarouf, Urs Rutishauser, Claire Henchcliffe, Yongzeng Wang, Isabelle Riviere, Shannon Mann, Vladimir Bermudez, Stefan Irion, Lorenz Studer, Mark Tomishima, Viviane Tabar
Summary: The study successfully generated midbrain dopamine neurons from human embryonic stem cells and conducted extensive tests on animals to demonstrate the efficacy and safety of the cell product intended for potential human use, paving the way for future clinical trials.
Article
Neurosciences
Di Wu, Michelle C. Klaw, Theresa Connors, Nikolai Kholodilov, Robert E. Burke, Veronica J. Tom
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biotechnology & Applied Microbiology
Min-Tae Jeon, Jin Han Nam, Won-Ho Shin, Eunju Leem, Kyoung Hoon Jeong, Un Ju Jung, Young-Seuk Bae, Young-Ho Jin, Nikolai Kholodilov, Robert E. Burke, Seok-Geun Lee, Byung Kwan Jin, Sang Ryong Kim
Article
Neurosciences
Patricia Tagliaferro, Tatyana Kareva, Tinmarla F. Oo, Olga Yarygina, Nikolai Kholodilov, Robert E. Burke
NEUROBIOLOGY OF DISEASE
(2015)
Review
Neurosciences
Robert E. Burke, Karen O'Malley
EXPERIMENTAL NEUROLOGY
(2013)
Article
Biochemistry & Molecular Biology
S. Padmanabhan, T. Kareva, N. Kholodilov, R. E. Burke
Article
Biochemistry & Molecular Biology
Neelam Shahani, William Pryor, Supriya Swarnkar, Nikolai Kholodilov, Gopal Thinakaran, Robert E. Burke, Srinivasa Subramaniam
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E. Burke
JOURNAL OF NEUROCHEMISTRY
(2011)
Article
Neurosciences
Hsiao-Chun Cheng, Sang Ryong Kim, Tinmarla F. Oo, Tatyana Kareva, Olga Yarygina, Margarita Rzhetskaya, Chuansong Wang, Matthew During, Zsolt Talloczy, Keiji Tanaka, Masaaki Komatsu, Kazuto Kobayashi, Hideyuki Okano, Nikolai Kholodilov, Robert E. Burke
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Jin Han Nam, Eunju Leem, Min-Tae Jeon, Kyoung Hoon Jeong, Jeen-Woo Park, Un Ju Jung, Nikolai Kholodilov, Robert E. Burke, Byung Kwan Jin, Sang Ryong Kim
MOLECULAR NEUROBIOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Sang Ryong Kim, Tatyana Kareva, Olga Yarygina, Nikolai Kholodilov, Robert E. Burke
Article
Neurosciences
Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F. Oo, W. Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E. Burke
NEUROBIOLOGY OF DISEASE
(2011)
Article
Neurosciences
Daniela Hernandez, Clara A. Torres, Wanda Setlik, Carolina Cebrian, Eugene V. Mosharov, Guomei Tang, Hsiao-Chun Cheng, Nikolai Kholodilov, Olga Yarygina, Robert E. Burke, Michael Gershon, David Sulzer
Review
Chemistry, Multidisciplinary
Verity Baltutis, Paul D. O'Leary, Lisandra L. Martin
Summary: Antimicrobial peptides are a crucial defense mechanism of hosts against microbial assailants. They undergo a structural transition upon contact with membrane surfaces, leading to the destruction of microbes through detergent-like binding or formation of trans-membrane pores. Recent findings also suggest a potential link between self-assembled antimicrobial peptides and diseases like Alzheimer's disease. This review highlights the importance of studying the self-assembly of antimicrobial peptides into amyloid and its synergistic effect with the antimicrobial peptide response.
Article
Nursing
Lynette Kelley, Kirsten Broadfoot, Marina McCreight, Ashlea Wills, Chelsea Leonard, Brigid Connelly, Heather Gilmartin, Robert E. Burke
Summary: The purpose of this study was to create, implement, and evaluate a nursing transitional care coordination curriculum, the Transitions Nurse Training Program (TNTP). The results showed that the program had a positive impact on trained nurses, increasing their engagement, satisfaction, knowledge, and confidence. They also achieved high scores in clinical and communication skills, with sustained skill performance after training.
JOURNAL OF NURSING CARE QUALITY
(2023)
Article
Chemistry, Multidisciplinary
Meri Ayurini, Peter G. Chandler, Paul D. O'Leary, Ruoxin Wang, David Rudd, Karen D. Milewska, Lara R. Malins, Ashley M. Buckle, Joel F. Hooper
Summary: Cobalt-mediated radical polymerizations (CMRPs) have been achieved through the radical decarboxylation of tetrachlorophthalimide activated esters. This method allows for controlled radical polymerization of activated monomers across a wide temperature range using a single cobalt species, while incorporating polymer end groups derived from simple carboxylic acid derivatives and terminating with an organozinc reagent.