Article
Environmental Sciences
Yu Han, Wei Shi, Yu Tang, Weishang Zhou, Hongxiang Sun, Jiongming Zhang, Maocang Yan, Lihua Hu, Guangxu Liu
Summary: The study investigated the effects of microplastics and bisphenol A on gonadal development in whiteleg shrimp, revealing significant inhibition of gonadal development probably through interfering with metabolism and disrupting endocrine regulation. Co-exposure to both pollutants was more toxic and led to increased accumulation of BPA in shrimp gonads, potentially due to the Trojan horse effect and cumulative toxic impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Meimei Li, Boliao Li, Qi Yang, Yanying Li, Junxiang Wu, Xiangli Xu
Summary: In this study, we identified 50 neuropeptides including neuropeptide Y (NPY) of Mythimna separata using transcriptome sequencing. The spatial and temporal expression profile of NPY indicated its important role in feeding regulation and energy metabolism. Knockdown of NPY significantly inhibited food uptake and body weight, delayed developmental duration, and altered energy storage in M. separata larvae.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yulin Zhang, Yang Kong, Yuan Ma, Shilei Ni, Tobias Wikerholmen, Kaiyan Xi, Feihu Zhao, Zhimin Zhao, Junpeng Wang, Bin Huang, Anjing Chen, Zhong Yao, Mingzhi Han, Zichao Feng, Yaotian Hu, Frits Thorsen, Jian Wang, Xingang Li
Summary: The research identified COPZ1 as a therapeutic target candidate for GBM due to its role in dysregulating iron metabolism, leading to increased tumor grade and poor prognosis. Suppression of COPZ1 through siRNA knockdown inhibited proliferation and tumor growth of GBM cells both in vitro and in vivo, suggesting COPZ1/NCOA4/FTH1 axis as a potential novel therapeutic target for human GBM.
Article
Biochemistry & Molecular Biology
Reinaldo Sousa Dos Santos, Regla Maria Medina-Gali, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
Summary: Identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity are necessary. This study used various cell lines to assess the effects of endocrine disruptors on cell viability and glucose-stimulated insulin secretion (GSIS). Results suggest that one chemical could be a new diabetogenic agent, and the EndoC-beta H1 cell line is a suitable human beta-cell model for testing diabetogenic MDCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jinpeng Tang, Chencheng Zhang, Jinhua Zhang, Yanyan Jia, Ji Fang
Summary: The increasing concentration of endocrine disrupting compounds (EDCs) in the aquatic environment has irreversible effects on biota's endocrine and reproductive systems. This study measured the concentrations of seven common EDCs in fish, invertebrate species, and plankton collected from South China. The results showed that fish had the highest EDC concentrations, with 4-nonylphenol and bisphenol S being the predominant components. Trophic magnification factors (TMFs) were negatively correlated with in vitro biotransformation clearance rates (CL in vitro) and CYP450 enzymes activities, indicating that metabolism plays a significant role in the trophic transfer of EDCs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Matteo Barberis, Thierry D. G. A. Mondeel
Summary: Transcription factors are essential for regulating the genomic landscape of cells, and the Forkhead (Fkh) transcription factors have been shown to play important roles in the regulation of organismal physiology and cell division. Genome-wide studies, including Chromatin ImmunoPrecipitation (ChIP) assays, have provided insights into the genomic landscape regulated by Forkheads in eukaryotes. These studies have revealed the involvement of Forkheads in the regulation of metabolic networks and temporal coordination of cell cycle dynamics.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Endocrinology & Metabolism
Maia Corpuz-Hilsabeck, Martine Culty
Summary: Sertoli cells play crucial roles in male reproduction, and dysregulation of their functions can have lifelong adverse effects on testis development and spermatogenesis. Understanding the impact of endocrine disrupting chemicals and drugs on Sertoli cells is important for comprehending the adverse outcomes on the reproductive system that these compounds may induce.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huazhong Zhang, Hao Wu, Jian Qian, Li Sun, Leqi Sang, Pengfei Wang, Beilei Yuan, Jinsong Zhang
Summary: Phospholipid metabolic disorder plays a crucial role in the development of SA-AKI. The increased activity of LPCAT3 and decreased expression of miR-124-3p.1 may lead to ferroptosis. These findings contribute to the early diagnosis and renal replacement therapy for SA-AKI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Jana Skerlova, Aram Ismail, Helena Lindstrom, Birgitta Sjodin, Bengt Mannervik, Pal Stenmark
Summary: Organotin compounds are highly toxic environmental pollutants that disrupt the normal functioning of the nervous and endocrine systems. They inhibit glutathione transferases, impeding detoxification and antioxidant functions. Structural studies show that organotin compounds block enzyme activity by forming strong bonds, providing insight into their toxic effects.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Jiachen Sun, Runcheng Fang, Hua Wang, De-Xiang Xu, Jing Yang, Xiaochen Huang, Daniel Cozzolino, Mingliang Fang, Yichao Huang
Summary: The exposure to environmental toxicants can lead to metabolic diseases, such as diabetes and obesity, through disturbances in key metabolic and signaling pathways. Research on metabolism disrupting chemicals (MDCs) becomes important to understand these risks. Various contaminants like EDCs, heavy metals, and emerging substances have been linked with metabolic disorders, highlighting the need for further studies on combined effects and metabolic alterations for better toxicity assessment and public health management.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Shuang Wang, Zhiyu Wang, Xumin Wang, Jiangyong Qu, Fei Li, Chenglong Ji, Huifeng Wu
Summary: This study found that the novel brominated flame retardant DBDPE has reproductive endocrine-disrupting effects on marine mussels. It promotes gametogenesis and suppresses genes related to cholesterol homeostasis and transport. DBDPE also disrupts nongenomic signaling pathways and alters the expression levels of reproductive genes. These findings provide important references for ecological risk assessment of DBDPE pollution in the marine environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Multidisciplinary Sciences
Hehe He, Youran Li, Liang Zhang, Zhongyang Ding, Guiyang Shi
Summary: This article aims to provide a systematic introduction to nitrogen metabolism in Bacillus, an important industrial microorganism, and apply its regulatory logic to synthetic biology to improve biosynthesis competitiveness. Understanding the meticulous regulation process of nitrogen metabolism not only facilitates metabolic engineering research but also provides constructive insights and inspiration for studies of other microorganisms.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Ana P. Teixeira, Pascal Stucheli, Simon Auslander, David Auslander, Pascal Schonenberger, Samuel Hurlemann, Martin Fussenegger
Summary: The researchers have developed an antibiotic-free selection system for generating stable transgenic cell lines, which utilizes cellobiose as the primary energy source. By combining this system with a PiggyBac transposase-based integration strategy, they were able to efficiently generate stable transgenic cell lines that expressed high levels of cargo proteins. This strategy was successfully validated by integrating sequences encoding two biopharmaceutical proteins, erythropoietin and the monoclonal antibody rituximab, and confirmed their efficient production in both cellobiose- and glucose-containing medium.
METABOLIC ENGINEERING
(2022)
Article
Environmental Sciences
Sujin Lee, Bareum Kwon, Junhyeok Jeong, Younglim Kho, Kyunghee Ji
Summary: In this study, the adverse effects of benzisothiazolinone (BIT) on the thyroid neuroendocrine system of zebrafish embryos/larvae were investigated. BIT exposure resulted in coagulation and hatching delay, decreased hatchability and larval survival, and altered gene expression related to thyroid hormones and thyrotropin-releasing hormone secretion. The underlying mechanisms involve central regulation, receptor binding, and deiodination.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Lei Zhang, Julia Koller, Gopana Gopalasingam, Yue Qi, Herbert Herzog
Summary: The NPFF signaling has a significant role in regulating glucose metabolism and may modulate whole-body glucose homeostasis through centrally vagal pathways. Targeting NPFF and NPFFR2 signaling could be a new approach for treating type 2 diabetes and obesity.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)