期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 373, 期 1-2, 页码 68-76出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.10.010
关键词
Polycystic ovary syndrome; Adipocyte; Adipokine; Steroid; Fat distribution
资金
- Medical Research Council [G0802782] Funding Source: Medline
- MRC [G0802782] Funding Source: UKRI
Polycystic Ovary Syndrome (PCOS) is a common endocrinopathy that is associated with an adverse metabolic profile including insulin resistance. There is a clear association between obesity, the development of PCOS and the severity of its phenotypic, biochemical and metabolic features. Evidence to support this link includes data from epidemiological, pathophysiological and genetic studies. Given the importance of obesity in the development and manifestation of PCOS, ongoing research into the many facets of adipocyte biology in women with the condition is important and should continue to be a priority. In this review article, we discuss the existing literature on fat distribution, adipokines, adipocyte hypertrophy and adipocyte steroid metabolism in women with PCOS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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