Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Article
Endocrinology & Metabolism
Marlene Hager, Didier Dewailly, Rodrig Marculescu, Stefan Ghobrial, John Preston Parry, Johannes Ott
Summary: In a retrospective cohort study, it was found that women with stress-induced functional hypothalamic amenorrhea (FHA) have a higher prevalence of polycystic ovarian morphology (PCOM) compared to women with exercise-induced FHA. The stress group also exhibited higher levels of prolactin and a trend towards higher levels of dehydroepiandrosterone-sulphate (DHEAS). This suggests that the well-known stress sensitivity in women with polycystic ovary syndrome (PCOS) may explain their propensity to develop FHA and the high prevalence of PCOM in FHA women.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Evolutionary Biology
Natalie L. Dinsdale, Bernard J. Crespi
Summary: Evolutionary and comparative approaches can provide new insights into human adaptation and disease. The study proposes the diametric disorder hypothesis between endometriosis and PCOS, with support from diverse fields of research. Findings suggest that PCOS and endometriosis represent maladaptive extremes of female life-history variation and expression of sexually dimorphic female reproductive traits.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Medicine, General & Internal
Karina Kapczuk, Weronika Zajaczkowska, Klaudyna Madziar, Witold Kedzia
Summary: This study aimed to assess the prevalence and course of endometriosis in adolescents with obstructive Mullerian anomalies. The study found that 46% of the 50 adolescents who underwent surgical treatment were diagnosed with endometriosis. Persistent dysmenorrhea affected 28% of the adolescents, with 47.1% diagnosed with endometriosis at the time of surgical correction. Conclusion: About half of the young adolescents who undergo surgical treatment for obstructive Mullerian anomalies after menarche develop endometriosis, with the highest incidence in girls with cervical aplasia. Surgical correction can reduce the risk of developing endometriosis, but significant risk still exists in patients with uterine anomalies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Amin Ullah, Mei-Jiao Wang, Ying-Xiong Wang, Bairong Shen
Summary: Reproductive health is particularly important for women during their reproductive age. Female reproductive problems such as polycystic ovary syndrome (PCOS) and endometriosis affect about 10% of women, negatively impacting their health, fertility, and quality of life. CXC chemokines, small chemotactic and secreted cytokines, are found to be dysregulated in both PCOS and endometriosis, playing a critical role in the development and progression of these diseases. Studies have shown that CXC chemokines promote inflammation and are involved in angiogenesis and inflammatory responses. Overexpression of CXC chemokines is associated with poor survival and prognosis. The levels of CXC chemokines significantly impact the circumstances of PCOS and endometriosis patients, indicating their potential as diagnostic and prognostic biomarkers and therapeutic targets. The molecular mechanisms underlying how CXC chemokines promote inflammation and the development of PCOS and endometriosis are currently unknown. This article aims to discuss the functions of CXC chemokines in the promotion, development, and therapy of PCOS and endometriosis, as well as future research directions. The current state and future prospects of CXC chemokine-based therapeutic strategies in managing PCOS and endometriosis are also highlighted.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Fei Li, Ying Chen, Aiqin Niu, Yajing He, Ying Yan
Summary: The study identified FSH, AMH, E2 value on the day of hCG injection, total dosage of Gn used, and follicle number on the day of hCG injection as independent risk factors for OHSS in PCOS patients. The newly established nomogram model proved to be an effective tool for predicting OHSS probability.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Zhenyan Pan, Fangfang Zhu, Kai Zhou
Summary: Anogenital distance (AGD) reflects androgen exposure during gestational weeks 8-14 and has been linked to endocrine-disrupting compounds. Studies show that PCOS patients tend to have longer AGD, while endometriosis patients tend to have shorter AGD. Further well-designed studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yurong Cao, Hao Shi, Yue Ma, Linna Ma, Jun Zhai
Summary: Research showed that the incidence of high-risk OHSS in PCOS patients after oocyte retrieval fluctuated with seasonal changes, especially in summer and winter. The prediction model established based on independent risk factors had good predictive performance and clinical application value.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Mala S. Sivanandy, Sierra K. Ha
Summary: Polycystic ovary syndrome (PCOS) is an endocrinological disorder with significant implications for women's reproductive, metabolic, and psychological health. The lack of a specific diagnostic test poses challenges in diagnosing PCOS, resulting in underdiagnosis and undertreatment. Anti-Mullerian hormone (AMH) appears to be a promising diagnostic marker for PCOS, with elevated levels correlating highly with PCOS features such as polycystic ovarian morphology, hyperandrogenism, and oligo/amenorrhea.
Article
Endocrinology & Metabolism
Mojgan Javedani Masroor, Hossein Sheybani, Shiva Sheybani, Nastaran Abolghasem
Summary: After laparoscopic ovarian drilling (LOD) in patients with PCOS, the mean AMH level decreases significantly and the menstrual cycle distribution changes significantly, but these variables do not affect the pregnancy rate.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu Ran, Qiang Yi, Cong Li
Summary: The study found that AMH levels were higher in PCOS patients compared to controls, with no difference in subgroups of PCOS patients under 30 years old. AMH levels in the PCOM subgroup were significantly higher than those in the HA subgroup, suggesting a strong relationship between AMH and PCOM but not with HA.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Mirte R. Caanen, Henrike E. Peters, Peter M. van de Ven, Anne M. F. M. Juttner, Joop S. E. Laven, Marcel H. A. van Hooff, Cornelis B. Lambalk
Summary: The study found that higher AMH levels in adolescence were associated with a higher risk of developing PCOS in adulthood for girls with oligomenorrhea. However, adolescent AMH levels alone or in combination with menstrual irregularities were not effective in predicting adult PCOS, and therefore routine use in clinical practice is not recommended.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Camille Bourgneuf, Danielle Bailbe, Antonin Lamaziere, Charlotte Dupont, Marthe Moldes, Dominique Farabos, Natacha Roblot, Camille Gauthier, Emmanuelle Mathieu D'Argent, Joelle Cohen-Tannoudji, Danielle Monniaux, Bruno Feve, Jamileh Movassat, Nathalie di Clemente, Chrystele Racine
Summary: The authors report a rat model that spontaneously exhibits the clinical heterogeneity of PCOS and demonstrate that the phenotype is developmentally programmed. This rodent model provides a novel tool for identifying the mechanisms involved in the pathogenesis of PCOS and developing new treatment strategies.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Susanne Schueler-Toprak, Olaf Ortmann, Christa Buechler, Oliver Treeck
Summary: This review article provides an update on the role of adipokines in polycystic ovary syndrome (PCOS) and endometriosis, as well as summarizes previous findings. The article also discusses the involvement of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes, and epigenetic alterations of adipokine genes. Furthermore, the article addresses the notable effects of brown adipose tissue (BAT) on PCOS.
Article
Multidisciplinary Sciences
Abeer M. Rababa'h, Bayan R. Matani, Alaa Yehya
Summary: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by menstrual irregularities, chronic anovulation, hirsutism, androgenic alopecia, and acne. Most patients seek medical care due to clinical symptoms such as hirsutism, menstrual irregularities, and infertility. Treatment strategies include lifestyle interventions and pharmacological agents. Lifestyle interventions are the first line treatment for overweight females seeking pregnancy. The use of specific therapeutic agents and lifestyle interventions can help patients recover their reproductive and metabolic health.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)