期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 361, 期 1-2, 页码 133-142出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.03.022
关键词
EGF; Activin; Ovary; Zebrafish
资金
- RGC/GRF grants from the Research Grants Council of the Hong Kong Special Administrative Region
- Area of Excellence Scheme grant from the University Grants Committee of Hong Kong [AoE/P-04/2004]
Epidermal growth factor (EGF) promotes oocyte maturation in the zebrafish and its effect is mediated via the activin system. However, the mechanisms by which EGF regulates activin subunits in the follicle cells remain unknown. The present study demonstrated that EGF controlled expression of three activin subunits (inhbaa, inhbab and inhbb) in the follicle cells via diverse signaling pathways. The expression of inhbaa and inhbb was often co-regulated via similar pathways. Suppression of MAPK3/1, p38 MAPK, PKC and PKA each blocked or partially reduced the stimulatory effects of EGF on the expression of inhbaa and inhbb while up-regulated that of inhbab. Conversely, inhibition of PI3K did not have any effect on the expression of inhbaa and inhbb but significantly suppressed the stimulatory effect of EGF on inhbab. In summary, EGF action in the zebrafish ovary involves activin system and its regulation of activin subunits is mediated by diverse signaling pathways downstream of EGFR. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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