Article
Chemistry, Multidisciplinary
Liang-yun Li, Jun-fa Yang, Fan Rong, Zhi-pan Luo, Shuang Hu, Hui Fang, Ying Wu, Rui Yao, Wei-hao Kong, Xiao-wen Feng, Bang-jie Chen, Jun Li, Tao Xu
Summary: ZEB1 plays a crucial role in hepatocellular carcinoma (HCC) by promoting cell proliferation, migration, and invasion through activating the Wnt/β-catenin signaling pathway. Meanwhile, miR-708 inhibits the growth and metastasis of HCC cells by targeting ZEB1.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Biochemistry & Molecular Biology
Jose Mario Gonzalez-Meljem, Juan Pedro Martinez-Barbera
Summary: Cellular senescence can prevent tumour development autonomously but also promote tumour growth non-autonomously by creating a permissive tumour microenvironment. In a specific pituitary tumour ACP, senescent cell clusters with SASP play a critical role in tumour initiation. Evidence suggests that paracrine signalling from senescent cells may underlie tumourigenesis in various tumour and cancer models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
K. A. Pickering, K. Gilroy, J. W. Cassidy, S. K. Fey, A. K. Najumudeen, L. B. Zeiger, D. F. Vincent, D. M. Gay, J. Johansson, R. P. Fordham, B. Miller, W. Clark, A. Hedley, E. B. Unal, C. Kiel, E. McGhee, L. M. Machesky, C. Nixon, A. E. Johnsson, M. Bain, D. Strathdee, S. R. van Hoof, J. P. Medema, K. Anderson, S. M. Brachmann, V. M. Stucke, A. Malliri, M. Drysdale, M. Turner, L. Serrano, K. Myant, A. D. Campbell, O. J. Sansom
Summary: Indirect targeting of RAC1 via RAC-GEFs can effectively suppress hyperproliferation and tumorigenesis in the murine intestine without affecting normal intestinal homeostasis. Combined targeting of three RAC-GEFs can effectively inhibit RAC1 activity and delay intestinal tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dan Li, Yanan Cao, Juan Wang, Haiyan Yang, Weina Liu, Jinfeng Cui, Wenxin Wu
Summary: High expression of HMGA2 in colorectal cancer tissues compared with adjacent normal tissues suggests its potential involvement in the carcinogenesis of sporadic colorectal tubular adenoma, possibly through synergistic interaction with the Wnt/beta-catenin signaling pathway. Experimental results also indicate coordinated regulation between HMGA2 and Wnt/beta-catenin signaling pathway in carcinogenesis of sporadic colorectal tubular adenoma.
Article
Biochemistry & Molecular Biology
Pusheng Yang, Panpan Zhang, Shu Zhang
Summary: Disease recurrence and metastasis have a negative impact on the prognosis of advanced endometrial carcinoma (EC) patients. RNA-binding proteins (RBPs), although their exact role in EC is unknown, have been associated with tumor development and metastasis. This study used various databases to identify RBPs and focused on MEX3A, which was found to be upregulated and associated with poor prognosis in EC patients. Experimental evidence showed that MEX3A promotes the growth, migration, and invasion of EC cells. Mechanistically, MEX3A interacts with DVL3 to stabilize beta-catenin, leading to enhanced epithelial-mesenchymal transition (EMT) and activation of the Wnt/beta-catenin pathway. Therefore, MEX3A may be a potential therapeutic target for EC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fei-fei Pan, Yan-Biao Zheng, Chuan-Jian Shi, Feng-wei Zhang, Jin-fang Zhang, Wei-ming Fu
Summary: The research demonstrates that apigenin (API) can suppress tumor growth of hepatocellular carcinoma (HCC) by down-regulating the H19-mediated Wnt/beta-catenin signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Morgan K. K. Penny, Antonio M. M. Lerario, Kaitlin J. J. Basham, Sahiti Chukkapalli, Dipika R. R. Mohan, Chris LaPensee, Kimber Converso-Baran, Mark J. J. Hoenerhoff, Laura Suarez-Fernandez, Carmen Gonzalez del Rey, Thomas J. J. Giordano, Ruolan Han, Erika A. A. Newman, Gary D. D. Hammer
Summary: Adrenocortical carcinoma (ACC) is a rare and aggressive cancer with limited treatment options. This study identified a novel Wnt/β-catenin-associated signature enriched in ECM, which was predictive of poor survival in ACC patients. Inhibition of Wnt/β-catenin signaling reduced ECM expression and cancer cell viability, suggesting it as a potential therapeutic strategy for ACC.
Article
Oncology
Stefan Stoiber, Faris F. Brkic, Tobias Maier, Julia Schnoell, Elisabeth Gurnhofer, Gregor Heiduschka, Lorenz Kadletz-Wanke, Lukas Kenner
Summary: This study evaluated the prognostic relevance of the Wnt/beta-CATENIN pathway in patients with HPV-positive HNSCC. High CTNNB1 expression was linked to better overall survival, and high beta-CATENIN expression was significantly associated with a better overall survival as well. Thus, beta-CATENIN expression may serve as a marker for better survival outcomes in patients with HPV-positive HNSCC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li, Xinzhi Peng
Summary: The study revealed the transcriptional regulation of LINC01278 by beta-catenin/LEF-1 transcription factor and its negative feedback regulation on beta-catenin signal in papillary thyroid carcinoma (PTC) cells. This negative regulation inhibits downstream target gene expression activated by the Wnt/beta-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Article
Plant Sciences
Cai-Wen Fan, Juan Tang, Jing-Chen Jiang, Mei-Mei Zhou, Mei-Shan Li, Heng-Shan Wang
Summary: This study demonstrated that PGG can inhibit proliferation, induce apoptosis and autophagy, and decrease metastatic capacity of NPC cells. Mechanistically, PGG exerts its effects through the p38 MAPK/mTOR and Wnt/beta-catenin pathways, providing evidence for PGG as a potential therapeutic option for NPC.
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhaobo Cheng, Renjie Yu, Li Li, Junhao Mu, Yijia Gong, Fan Wu, Yujia Liu, Xiangyi Zhou, Xiaohua Zeng, Yongzhong Wu, Ran Sun, Tingxiu Xiang
Summary: In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancer tissues and TNBC cell lines, likely due to promoter hypermethylation. Ectopic expression of ZNF334 suppressed the growth and metastatic capacity of TNBC cell lines, induced cell cycle arrest at S phase and apoptosis. Additionally, re-expression of ZNF334 restored the Epithelial-Mesenchymal Transition (EMT) process and inhibited stemness by up-regulating SFRP1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Jeffrey C. Francis, Jennifer R. Gardiner, Yoan Renaud, Ritika Chauhan, Yacob Weinstein, Celso Gomez-Sanchez, Anne-Marie Lefrancois-Martinez, Jerome Bertherat, Pierre Val, Amanda Swain
Summary: This study found that high expression of HOXB9 and other HOX factors is associated with poorer prognosis in ACC patients. HOXB9 can promote adrenal tumor progression in a sex-dependent manner, and tumor cells are dependent on HOX function for survival. These findings have identified HOX factors as potential drug targets for novel therapeutic approaches in ACC.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Leticia Ferro Leal, Eva Szarek, Annabel Berthon, Maria Nesterova, Fabio R. Faucz, Edra London, Christopher Mercier, Mones Abu-Asab, Matthew F. Starost, Louis Dye, Barbara Bilinska, Malgorzata Kotula-Balak, Sonir R. Antonini, Constantine A. Stratakis
Summary: The study found that PDE8B has a weak role in endocrine disorders involving the Wnt/beta-catenin signaling and PKA signaling; PDE8B appears to play a significant role in male fertility.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Andrea Gutierrez Maria, Kleiton Silva Borges, R. C. P. Lira, Carolina Hassib Thome, Annabel Berthon, Ludivine Drougat, Katja Kiseljak-Vassiliades, Margaret E. Wierman, Fabio R. Faucz, Vitor Marcel Faca, Luiz Gonzaga Tone, Constantine A. Stratakis
Summary: A combination of aurora kinase inhibitor and beta-catenin pathway blocker showed decreased cell proliferation and viability in ACC cell lines, suggesting a potential combinatorial approach for targeting ACC tumors.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Anna Vaczlavik, Lucas Bouys, Florian Violon, Gaetan Giannone, Anne Jouinot, Roberta Armignacco, Isadora P. Cavalcante, Annabel Berthon, Eric Letouze, Patricia Vaduva, Maxime Barat, Fideline Bonnet, Karine Perlemoine, Christopher Ribes, Mathilde Sibony, Marie-Odile North, Stephanie Espiard, Philippe Emy, Magalie Haissaguerre, Igor Tauveron, Laurence Guignat, Lionel Groussin, Bertrand Dousset, Martin Reincke, Maria C. Fragoso, Constantine A. Stratakis, Eric Pasmant, Rossella Libe, Guillaume Assie, Bruno Ragazzon, Jerome Bertherat
Summary: This study identified KDM1A gene inactivation as the cause of food-dependent Cushing syndrome (FDCS) in 90% of primary bilateral macronodular adrenal hyperplasia (PBMAH) cases. Through multiomics analysis of patient tissues, the study classified patients into different molecular groups and suggested genetic screening for ARMC5 and KDM1A for earlier diagnosis and improved management.
GENETICS IN MEDICINE
(2022)
Article
Dermatology
Isabelle Sahut-Barnola, Anne-Marie Lefrancois-Martinez, Damien Dufour, Jean-Marie Botto, Crystal Kamilaris, Fabio R. Faucz, Constantine A. Stratakis, Pierre Val, Antoine Martinez
Summary: Carney complex is a rare familial multineoplastic syndrome characterized by skin lesions. This study demonstrates that inactivation of the Prkar1a gene leads to familial skin pigmentation alterations, revealing the pathogenesis of cutaneous manifestations in Carney complex.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Surgery
Elisabeth Hain, Amine Chamakhi, Charlotte Lussey-Lepoutre, Jerome Bertherat, Christophe Baillard, Gilles Manceau, Louis Puybasset, Jacques Blacher, Bernard Cholley, Anne-Paule Gimenez-Roqueplo, Bertrand Dousset, Laurence Amar, Fabrice Menegaux, Sebastien Gaujoux
Summary: According to the study results, patients with pheochromocytomas/paragangliomas who underwent surgery after presenting with Takotsubo-like cardiomyopathy can be safely operated with low risk of perioperative complications and good postoperative outcomes.
Review
Endocrinology & Metabolism
Laurence Guignat, Jerome Bertherat
Summary: Transsphenoidal surgery is the first-line treatment for Cushing's disease, with a remission rate of 70%-80%. However, the long-term remission rate is lower due to recurrence. Postoperative corticotroph insufficiency and its duration have been found to be protective factors against recurrence. Long-term monitoring with clinical and hormonal investigations is advised after postoperative recovery of the hypothalamic-pituitary-adrenal axis.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Isadora P. Cavalcante, Annabel Berthon, Maria C. Fragoso, Martin Reincke, Constantine A. Stratakis, Bruno Ragazzon, Jerome Bertherat
Summary: Recent progress in understanding the genetics of PBMAH has led to a better understanding of its pathophysiology and opened new clinical perspectives.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Oncology
Isadora P. Cavalcante, Marthe Rizk-Rabin, Christopher Ribes, Karine Perlemoine, Constanze Hantel, Annabel Berthon, Jerome Bertherat, Bruno Ragazzon
Summary: This study reveals the role of ARMC5 as a regulator of redox homeostasis in adrenocortical cells, controlling steroidogenesis and cell survival.
ENDOCRINE-RELATED CANCER
(2022)
Article
Endocrinology & Metabolism
Florian Violon, Lucas Bouys, Annabel Berthon, Bruno Ragazzon, Maxime Barat, Karine Perlemoine, Laurence Guignat, Benoit Terris, Jerome Bertherat, Mathilde Sibony
Summary: Bilateral macronodular adrenocortical disease (BMAD) is characterized by the development of adrenal macronodules resulting in a pituitary-ACTH independent Cushing's syndrome. In this study, the pathological features of 35 BMAD patients were analyzed, and 4 histopathological subtypes were identified. This classification highlights the heterogeneous pathological characteristics of BMAD, which correlate with certain genetic alterations identified in patients.
ENDOCRINE PATHOLOGY
(2023)
Meeting Abstract
Oncology
Andrea G. Maria, Kleiton S. Borges, Regia C. Lira, Carolina H. Thome, Annabel Berthon, Ludivine Drougat, Fabio R. Faucz, Vitor M. Faca, Luiz G. Tone, Constantine A. Stratakis
Article
Endocrinology & Metabolism
Rachel Wurth, Amit Tirosh, Crystal D. C. Kamilaris, Jancarlos Camacho, Fabio R. Faucz, Andrea Gutierrez Maria, Annabel Berthon, Georgios Z. Papadakis, Naris Nilubol, Ahmed Hamimi, Ahmed M. Gharib, Andrew Demidowich, Mihail Zilbermint, Graeme Eisenhofer, Leah Braun, Martin Reincke, Constantine A. Stratakis, Fady Hannah-Shmouni
Summary: This study conducted volumetric modeling of adrenal gland size in 44 patients with PBMAH, showing a positive correlation between adrenal volume and biochemical disease severity in Black patients, providing a useful tool for assessing PBMAH in this population.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Endocrinology & Metabolism
Kiran S. Nadella, Annabel Berthon, Madson Q. Almeida, Isaac Levy, Fabio R. Faucz, Constantine A. Stratakis
Summary: The study found that PRKAR1A mutations in PPNAD led to over-expression of IGF2 protein compared to other benign adrenocortical lesions such as PMAH and CPA. However, there was no correlation between IGF2 mRNA levels and LOI of IGF2/H19, indicating potentially different mechanisms of IGF2 gene expression control in PPNAD.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
