Review
Endocrinology & Metabolism
Maran Ilanchezhian, Diana Grace Varghese, John W. Glod, Karlyne M. Reilly, Brigitte C. Widemann, Yves Pommier, Rosandra N. Kaplan, Jaydira Del Rivero
Summary: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis, especially in pediatric population. The incidence of pediatric ACC is higher in southern Brazil due to a higher prevalence of TP53 mutation. Current treatment protocols are based on adult ACC, with limited research on alternative treatments for pediatric ACC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Karina C. F. Tosin, Edith F. Legal, Mara A. D. Pianovski, Humberto C. Ibanez, Gislaine Custodio, Denise S. Carvalho, Mirna M. O. Figueiredo, Anselmo Hoffmann Filho, Carmem M. C. M. Fiori, Ana Luiza M. Rodrigues, Rosiane G. Mello, Karin R. P. Ogradowski, Ivy Z. S. Parise, Tatiana E. J. Costa, Viviane S. Melanda, Flora M. Watanabe, Denise B. Silva, Heloisa Komechen, Henrique A. Laureano, Edna K. Carboni, Ana P. Kuczynski, Gabriela C. F. Luiz, Leniza Lima, Tiago Tormen, Viviane K. Q. Gerber, Tania H. Anegawa, Sylvio G. A. Avilla, Renata B. Tenorio, Elaine L. Mendes, Rayssa D. Fachin Donin, Josiane Souza, Vanessa N. Kozak, Gisele S. Oliveira, Deivid C. Souza, Israel Gomy, Vinicius B. Teixeira, Helena H. L. Borba, Nilton Kiesel Filho, Guilherme A. Parise, Raul C. Ribeiro, Bonald C. Figueiredo
Summary: Pediatric adrenocortical tumors are common in southern Brazil due to a specific genetic variant. Newborn screening has led to early detection and better outcomes. Those not screened had varying disease stages and tumor weights, while screened children had better survival rates and earlier diagnoses. The cost of screening per year of life saved is estimated at $623 per patient.
Article
Endocrinology & Metabolism
Ana Carolina Bueno, Monica F. Stecchini, Junier Marrero-Gutierrez, Candy Bellido More, Leticia Ferro Leal, Debora Cristiane Gomes, Daniel Ferreira de Lima Neto, Silvia Regina Brandalise, Izilda Aparecida Cardinalli, Jose Andres Yunes, Thais Junqueira, Carlos Alberto Scrideli, Carlos Augusto Fernandes Molina, Fernando Silva Ramalho, Silvio Tucci, Fernanda Borchers Coeli-Lacchini, Ayrton Custodio Moreira, Leandra Ramalho, Ricardo Zorzetto Nicoliello Vencio, Margaret De Castro, Sonir Roberto R. Antonini
Summary: This study found that VDR hypermethylation and underexpression may be predictive and prognostic biomarkers for pediatric adrenocortical tumors.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Jian Zhang, Minglu Liu, Yujie Fang, Jinlong Li, Yin Chen, Shunchang Jiao
Summary: The study reveals that TP53 R273C mutation may serve as an indicator of prognosis for low-grade glioma (LGG), as it is associated with poorer prognosis, increased M2 macrophage infiltration, and higher tumor mutation burden (TMB).
FRONTIERS IN GENETICS
(2022)
Review
Medicine, Research & Experimental
Florica Sandru, Razvan-Cosmin Petca, Mara Carsote, Aida Petca, Mihai Cristian Dumitrascu, Adina Ghemigian
Summary: Adrenocortical carcinoma is an aggressive malignancy that affects both adults and children. It is characterized by hormonal imbalances and genetic abnormalities in children. Surgical removal is the recommended treatment option.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Immunology
Xiaoyu Liu, Xu Xu, Zhuozhuo Wu, Qungang Shan, Ziyin Wang, Zhiyuan Wu, Xiaoyi Ding, Wei Huang, Zhongmin Wang
Summary: This study analyzed the effects of KRAS/TP53 mutation status and tumor sideness on the immune microenvironment of colorectal cancer using integrated scRNA-seq data. Different functional immune cell subtypes were identified, including exhausted T cell subtypes and macrophages indicating unfavorable prognosis. The study also suggested potential therapeutic targets for dual mutant colorectal cancers and revealed the gradual remodeling of the immune microenvironment in colorectal cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiang-Mei Wen, Zi-Jun Xu, Ye Jin, Pei-Hui Xia, Ji-Chun Ma, Wei Qian, Jiang Lin, Jun Qian
Summary: AML is a heterogeneous disease with various molecular alterations, and immunotherapy has shown promise in its treatment. TP53 mutation is frequently mutated in AML and is associated with poor prognosis, TMB, and immunological features, making it a potential biomarker for predicting immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Kunpeng Luo, Zhipeng Qian, Yanan Jiang, Dongxu Lv, Kaibin Zhu, Jing Shao, Ying Hu, Chengqian Lv, Qianqian Huang, Yang Gao, Shizhu Jin, Desi Shang
Summary: This study comprehensively characterized the metabolic reprogramming pattern and tumor microenvironment (TME) heterogeneity across different cancer types. It proposed a predictive model for cancer prognosis and immunotherapy responsiveness, and explored a potential therapeutic drug.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Juraj Prejac, Natalija Dedic Plavetic, Kristina Gotovac Jercic, Fran Borovecki
Summary: Li-Fraumeni syndrome is a rare cancer predisposition syndrome caused by a germline mutation in the TP53 gene. This case report highlights a young woman with a positive family history for cancer, diagnosed with malignant solitary fibrous tumor and luminal B-like invasive breast cancer. Despite successful resection of both primary tumors, the sarcoma relapsed in the form of lung metastases, likely due to the TP53 gene variant identified through NGS analysis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jia Li, Zhaoyan Li, Yajie Ding, Yan Xu, Xiaohong Zhu, Nida Cao, Chen Huang, Mengmeng Qin, Feng Liu, Aiguang Zhao
Summary: Gastric cancer is a heterogeneous disease with various molecular subtypes. This study found that TP53 mutation and MET amplification in ctDNA are common in AGC patients and could predict disease progression.
Review
Oncology
Chandrayee Ghosh, Jiangnan Hu, Electron Kebebew
Summary: Adrenocortical carcinoma is a rare but relatively high-incidence malignant tumor. In recent years, significant progress has been made in understanding the molecular basis of adrenocortical carcinoma, revealing genetic differences between adult and pediatric cases and identifying multiple genes associated with tumor occurrence. The latest molecular research has also contributed to the development of a molecular classification system for adrenocortical carcinoma, which can predict prognosis and provide clues for the discovery of new therapeutic targets.
NATURE REVIEWS CANCER
(2023)
Review
Oncology
Thierry Soussi
Summary: With the advancement of genotyping technology, a large number of uncommon SNPs have been discovered, but many resources are biased towards European populations. TP53 gene is the most frequently mutated gene in human cancer, and its SNPs must be rigorously evaluated to avoid misclassifications. The recent discovery of numerous benign SNPs within the coding region of TP53 highlights the importance of including populations of different ethnic origins in genetic studies.
Article
Oncology
Luciana Chain Veronez, Paola Fernanda Fedatto, Carolina Alves Pereira Correa, Regia Caroline Peixoto Lira, Mirella Baroni, Keteryne Rodrigues da Silva, Paula Santos, David Santos Marco Antonio, Rosane de Paula Silva Queiroz, Sonir Roberto Rauber Antonini, Silvio Tucci Jr, Luciano Neder, Jose Andres Yunes, Silvia Regina Brandalise, Rodrigo Alexandre Panepucci, Luiz Gonzaga Tone, Carlos Alberto Scrideli
Summary: This study reveals associations between miRNA profiles and childhood ACT prognosis, suggesting that miRNAs could serve as useful biomarkers to distinguish patients with favorable and unfavorable clinical outcomes.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Amanda Scartezini Gozdziejewski, Clarice Wichinescki Zotti, Isabela Aparecida Moreira de Carvalho, Thairine Camargo dos Santos, Luana Rayana de Santi Walter, Karin Rosa Persegona Ogradowski, Karin Luiza Dammski, Heloisa Komechen, Monalisa Castilho Mendes, Emanuelle Nunes de Souza, Mariana Martins Paraizo, Ivy Zortea da Silva Parise, Guilherme Augusto Parise, Andre Luiz Grion, Gislaine Custodio, Rosiane Guetter Mello, Bonald C. Figueiredo
Summary: This study found that mothers of newborns with TP53 gene mutations experience anxiety within the first four months after birth. This is more common in mothers with pre-existing mental health vulnerabilities. Appropriate psychological support should be provided for these mothers and for mothers of newborns with other types of TP53 gene mutations in other countries.
Article
Oncology
Ana Carolina Bueno, Rui M. P. da Silva, Monica F. Stecchini, Junier Marrero-Gutierrez, Danillo C. de Almeida e Silva, Izilda Cardinalli, Carlos Alberto Scrideli, Thais Junqueira, Carlos A. F. Molina, Fernando Silva Ramalho, Silvio Tucci, Fernanda Borchers Coeli-Lacchini, Ayrton Custodio Moreira, Leandra N. Z. Ramalho, Silvia Brandalise, Jose Andres Yunes, Margaret de Castro, Ricardo Zorzetto Nicoliello Vencio, Sonir R. R. Antonini
Summary: This study aimed to evaluate the methylation profile of pediatric adrenocortical tumors (pACT) and its association with disease presentation and survival. The study found different tumor methylation profiles associated with the clinical evolution of pACT, even in the context of TP53 mutations. The results support tumor methylation profiling as a robust and independent prognostic biomarker, and suggest a list of candidate genes for further validation.
ENDOCRINE-RELATED CANCER
(2022)
Review
Clinical Neurology
Brent A. Orr, Michael R. Clay, Emilia M. Pinto, Chimene Kesserwan
ACTA NEUROPATHOLOGICA
(2020)
Article
Multidisciplinary Sciences
Andrew J. Murphy, Xiang Chen, Emilia M. Pinto, Justin S. Williams, Michael R. Clay, Stanley B. Pounds, Xueyuan Cao, Lei Shi, Tong Lin, Geoffrey Neale, Christopher L. Morton, Mary A. Woolard, Heather L. Mulder, Hyea Jin Gil, Jerold E. Rehg, Catherine A. Billups, Matthew L. Harlow, Jeffrey S. Dome, Peter J. Houghton, John Easton, Jinghui Zhang, Rani E. George, Gerard P. Zambetti, Andrew M. Davidoff
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Emilia Modolo Pinto, Fabio R. Faucz, Luana Z. Paza, Gang Wu, Elizabeth S. Fernandes, Jerome Bertherat, Constantine A. Stratakis, Enzo Lalli, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Bonald C. Figueiredo, Gerard P. Zambetti
Article
Oncology
Mirvat Surakhy, Marsha Wallace, Elisabeth Bond, Lukasz Filip Grochola, Husein Perez, Matteo Di Giovannantonio, Ping Zhang, David Malkin, Hannah Carter, Ivy Zortea S. Parise, Gerard Zambetti, Heloisa Komechen, Mariana M. Paraizo, Meghana S. Pagadala, Emilia M. Pinto, Enzo Lalli, Bonald C. Figueiredo, Gareth L. Bond
BRITISH JOURNAL OF CANCER
(2020)
Review
Endocrinology & Metabolism
Emilia Modolo Pinto, Gerard P. Zambetti, Carlos Rodriguez-Galindo
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Oncology
Jacquelyn Powers, Emilia M. Pinto, Thibaut Barnoud, Jessica C. Leung, Tetyana Martynyuk, Andrew Kossenkov, Aaron H. Philips, Heena Desai, Ryan Hausler, Gregory Kelly, Anh N. Le, Marilyn M. Li, Suzanne P. MacFarland, Louise C. Pyle, Kristin Zelley, Katherine L. Nathanson, Susan M. Domchek, Thomas P. Slavin, Jeffrey N. Weitzel, Jill E. Stopfer, Judy E. Garber, Vijai Joseph, Kenneth Offit, Jill S. Dolinsky, Stephanie Gutierrez, Kelly McGoldrick, Fergus J. Couch, Brooke Levin, Morris C. Edelman, Carolyn Fein Levy, Sheri L. Spunt, Richard W. Kriwacki, Gerard P. Zambetti, Raul C. Ribeiro, Maureen E. Murphy, Kara N. Maxwell
Article
Multidisciplinary Sciences
Emilia M. Pinto, Bonald C. Figueiredo, Wenan Chen, Henrique C. R. Galvao, Maria Nirvana Formiga, Maria Candida B. Fragoso, Patricia Ashton-Prolla, Enilze M. S. F. Ribeiro, Gabriela Felix, Tatiana E. B. Costa, Sharon A. Savage, Meredith Yeager, Edenir Palmero, Sahlua Volc, Hector Salvador, Jose Luis Fuster-Soler, Cinzia Lavarino, Guillermo Chantada, Dominique Vaur, Vicente Odone-Filho, Laurence Brugieres, Tobias Else, Elena M. Stoffel, Kara N. Maxwell, Maria Isabel Achatz, Luis Kowalski, Kelvin C. de Andrade, Alberto Pappo, Eric Letouze, Ana Claudia Latronico, Berenice B. Mendonca, Madson Q. Almeida, Vania B. Brondani, Camila M. Bittar, Emerson W. S. Soares, Carolina Mathias, Cintia R. N. Ramos, Moara Machado, Weiyin Zhou, Kristine Jones, Aurelie Vogt, Payal P. Klincha, Karina M. Santiago, Heloisa Komechen, Mariana M. Paraizo, Ivy Z. S. Parise, Kayla Hamilton, Jinling Wang, Evadnie Rampersaud, Michael R. Clay, Andrew J. Murphy, Enzo Lalli, Kim E. Nichols, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Marta Korbonits, Jinghui Zhang, Mark G. Thomas, Jon P. Connelly, Shondra Pruett-Miller, Yoan Diekmann, Geoffrey Neale, Gang Wu, Gerard P. Zambetti
Review
Oncology
Emilia Modolo Pinto, Gerard R. Zambetti
Article
Oncology
John R. Jeffers, Emilia M. Pinto, Jerold E. Rehg, Michael R. Clay, Jinling Wang, Geoffrey Neale, Richard J. Heath, Guillermina Lozano, Enzo Lalli, Bonald C. Figueiredo, Alberto S. Pappo, Carlos Rodriguez-Galindo, Wenan Chen, Stanley Pounds, Raul C. Ribeiro, Gerard P. Zambetti
Summary: The TP53-R337H founder mutation is highly prevalent in southern Brazil and is associated with pediatric adrenocortical tumors, early-onset breast cancers, and LFS. A knockin mutant p53 mouse model has been generated to study the variability in tumor susceptibility caused by this mutation.
Article
Oncology
Carlos Rodriguez-Galindo, Mark D. Krailo, Emilia M. Pinto, Farzana Pashankar, Christopher B. Weldon, Li Huang, Eliana M. Caran, John Hicks, M. Beth McCarville, David Malkin, Jonathan D. Wasserman, Antonio G. de Oliveira Filho, Michael P. LaQuaglia, Deborah A. Ward, Gerard Zambetti, Maria J. Mastellaro, Alberto S. Pappo, Raul C. Ribeiro
Summary: This study showed that surgery is effective for stage I ACC patients, while a combination of surgery and chemotherapy is beneficial for stage III patients. New treatments should be explored for high-risk stage IV patients due to their poor outcome with current standard treatments.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Emilia M. Pinto, Kara N. Maxwell, Hadeel Halalsheh, Aaron Phillips, Jacquelyn Powers, Suzanne MacFarland, Michael F. Walsh, Kelsey Breen, Maria N. Formiga, Richard Kriwacki, Kim E. Nichols, Roya Mostafavi, Jinling Wang, Michael R. Clay, Carlos Rodriguez-Galindo, Raul C. Ribeiro, Gerard P. Zambetti
Summary: Germline TP53 variants at exon 4-intron 4 junctions are frequent in pediatric adrenocortical tumors (ACT) and rare in other pediatric tumors. These variants result in improper expression and loss of function, and are associated with a high incidence of pediatric ACTs not consistent with classic Li-Fraumeni syndrome.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Carolyn M. Jablonowski, Hyea Jin Gil, Emilia M. Pinto, Prahalathan Pichavaram, Andrew M. Fleming, Michael R. Clay, Dongli Hu, Christopher L. Morton, Shondra M. Pruett-Miller, Baranda S. Hansen, Xiang Chen, Karissa M. Dieseldorff Jones, Yanling Liu, Xiaotu Ma, Jun Yang, Andrew M. Davidoff, Gerard P. Zambetti, Andrew J. Murphy
Summary: The study identified potential mechanisms of TERT activation in Wilms tumor, including mutations in the TERT promoter, increased methylation of the promoter, and genomic copy number amplifications. Conversely, inactivating WT1 mutations were associated with low TERT RNA levels and telomerase activity. N-MYC overexpression led to increased TERT promoter activity and transcription.
Article
Oncology
Viviane K. Q. Gerber, Mariana M. Paraizo, Humberto C. Ibanez, Jose C. Casali-da-Rocha, Emilia M. Pinto, Diancarlos P. Andrade, Marilea V. C. Ibanez, Heloisa Komechen, Mirna M. O. Figueiredo, Gislaine Custodio, Carmem M. C. M. Fiori, Jose H. G. Balbinotti, Jeanine M. Nardin, Thais A. Almeida, Olair O. Beltrame, Paula A. Yamada, Gabriel S. de Fraga, Lucas L. de Brito, Jamylle Martins, Viviane S. Melanda, Otavio A. B. Licht, Victoria Z. Teixeira, Sandy K. S. Pinho, Silvia Bottini, Enzo Lalli, Gerard P. Zambetti, Bonald C. Figueiredo
Summary: This study assessed the joint effect of environmental factors and the inherited TP53 p.R337H mutation on the development of breast cancer in three subregions of Southern Brazil. The results revealed that individuals living in heavily polluted environments are more susceptible to breast cancer due to this genetic mutation. Screening, genetic testing, medical improvements, and healthier lifestyle practices can help reduce the impact of environmental contaminants.
Meeting Abstract
Pathology
Michael Clay, Emilia Pinto, Cynthia Cline, Quynh Tran, Lin Tong, Elizabeth Azzato, Alberto Pappo, Michael Dyer, David Ellison, Stanley Pounds, Gerard Zambetti, Brent Orr, Raul Ribeiro
Article
Medicine, Research & Experimental
Emily A. Quinn, Jamie L. Maciaszek, Emilia M. Pinto, Aaron H. Phillips, David Berdy, Mohammad Khandwala, Santhosh A. Upadhyaya, Gerard P. Zambetti, Richard W. Kriwacki, David W. Ellison, Kim E. Nichols, Chimene Kesserwan
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2019)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)