期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 354, 期 1-2, 页码 85-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2012.01.002
关键词
Reproduction; Immunology; Toxicology; Environment; Fertility; Hormone
资金
- NIAID NIH HHS [R01 AI013541, R01 AI102838, R01 AI071761] Funding Source: Medline
- NICHD NIH HHS [U54 HD007495, P30 HD007495] Funding Source: Medline
The complexity of the human female reproductive tract (FRT) with its multiple levels of hormonally controlled immune protection has only begun to be understood. Dissecting the functions and roles of the immune system in the FRT is complicated by the differential hormonal regulation of its distinct anatomical structures that vary throughout the menstrual cycle. Although many fundamental mechanisms of steroid regulation of reproductive tract immune function have been determined, the effects of exogenous synthetic steroids or endocrine disruptors on immune function and disease susceptibility in the FRT have yet to be evaluated in detail. There is increasing evidence that environmental or synthetic molecules can alter normal immune function. This review provides an overview of the innate and adaptive immune systems, the current status of immune function in the FRT and the potential risks of environmental or pharmacological molecules that may perturb this system. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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