Article
Plant Sciences
Chan Su, Ruihong Zhang, Xiujuan Zhang, Mengxiao Lv, Xiang Liu, Kai Ao, Jing Hao, Yu-lan Mu
Summary: This study investigated the effect of different doses of Dingkun Pill on ovarian function in CTX-induced POI mice and explored its molecular mechanism through the PTEN/PI3K/AKT/FOXO3a signaling pathway. The results showed that Dingkun Pill could increase body weight, promote estrous cycle recovery, and improve ovarian pathology. It also regulated hormone levels, promoted follicle growth, and induced ovulation. The study provides valuable insights into the potential clinical application of Dingkun Pill for the treatment of POI.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yingjun Chen, Qinghua Liu, Ruiyan Liu, Chan Yang, Xiaodong Wang, Zaohong Ran, Shanshan Zhou, Xiang Li, Changjiu He
Summary: This study in a mouse model revealed that early folliculogenesis requires a minimum of two weeks, with different stages showing specific characteristics such as oocyte size at Type 4-5 stage and theca folliculi formation at PD10-12. The study also highlighted the importance of the PD22-23 period for studying puberty initiation, providing valuable insights into the biological events of this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Xuefeng Bai, Shaowei Wang
Summary: Premature ovarian failure (POF) is a multifactorial disease characterized by secondary amenorrhea, decreased estrogen levels, and increased gonadotropin levels in women under 40. The prevalence of POF is increasing and it has adverse effects on both the physiology and psychology of women. Hormone replacement therapy is the recommended treatment, and a multidisciplinary approach is needed to improve patients' quality of life. Recent studies suggest that the depletion of ovarian reserve function due to increased primordial follicular activation or insufficiency is the primary mechanism of POF. Therefore, understanding the processes and pathways involved in primordial follicle activation and exploring effective interventions are crucial for POF treatment.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
E. Fang, He Zhang, Wanli Yin, Chongyang Wang, Yuanli Liu, Yanze Li, Linlin Wang, Yue Wu, Runze Zhang, Chendan Zou, Tianjun Song, Cedric Matunda, Chaoxia Zou, Xu Gao
Summary: This study reveals the essential role of CPEB3 in ovarian follicle development and female fertility, as it regulates the expression of Gdf9 in oocytes. Cpeb3-mutant mice exhibit a phenotype similar to POI, providing new insights for the understanding and treatment of POI.
CELL DEATH & DISEASE
(2022)
Article
Developmental Biology
Okiko Habara, Catriona Y. Logan, Masami Kanai-Azuma, Roeland Nusse, Hinako M. Takase
Summary: Canonical WNT signaling is crucial for the activation of pre-granulosa cells during primordial follicle activation, supporting oocyte growth in mammalian ovaries.
Article
Agriculture, Dairy & Animal Science
Fernanda de Mello, Daniel Jaen Alonso, Natalia Pires Vieira Morais de Faria, Victor Hugo Marques, Ethiene Fernandes de Oliveira, Paulo Henrique de Mello, Leandro Cesar de Godoy, Renata Guimaraes Moreira
Summary: The vitrification process of ovarian follicles has been found to have molecular and membrane impacts, but does not compromise their capability for in vitro maturation, making it a strategic tool for aquaculture.
Review
Reproductive Biology
Aubrey Converse, Emily J. Zaniker, Farners Amargant, Francesca E. Duncan
Summary: This article presents a detailed protocol for culturing mouse ovarian follicles using an alginate hydrogel-based encapsulated in vitro growth system. The system supports follicle growth, development, and differentiation from the early primary follicle to the antral follicle stage. It has been successfully used to culture secondary follicles and resulted in viable pups after blastocyst transfer. The alginate-based eIVFG system has versatile applications, including investigating ovarian follicle biology, screening toxicity and bioactivity, and potential fertility preservation for endangered species and humans.
BIOLOGY OF REPRODUCTION
(2022)
Article
Reproductive Biology
Zhe Dong, Lu Zhang, Wei Wang, Fan Jiang, Hao Ai
Summary: This study found that zinc sulfate has a protective effect on pre-mature ovarian failure and granulosa cells treated with cisplatin, and reduces apoptosis by activating the PI3K/AKT/GSK3I3 signaling pathway, thus protecting the ovaries and preserving fertility. These results suggest that zinc sulfate may be a potential therapeutic agent for protecting the ovaries and preserving fertility during chemotherapy.
Article
Obstetrics & Gynecology
Fei Liu, Qin Wan, Pengfei Liu, Dengshun Miao, Xiuliang Dai, Li Chen
Summary: Chemical agents commonly used for cancer treatment can lead to premature ovarian insufficiency (POI), but the exact molecules responsible for this remain unclear. This study found that genetic ablation of the p16 gene does not protect against ovarian damage caused by these agents.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Review
Biochemistry & Molecular Biology
Elsa Labrune, Bruno Salle, Jacqueline Lornage
Summary: This article discusses the progress of in vitro folliculogenesis in humans, highlighting the lack of necessity for initiation activators in the first stage and the requirement for mechanical and/or enzymatic isolation of secondary follicles in the second stage. The need for further validation of this technique is also addressed.
Review
Cell Biology
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon
Summary: Premature ovarian insufficiency (POI) is a condition characterized by the loss of normal ovarian function before the age of 40, affecting a small percentage of women under 40. The condition is biochemically defined by amenorrhea, low estrogen levels, and high gonadotropin levels, potentially leading to infertility. POI has a heterogeneous etiology, including both genetic and non-genetic factors, and current research focuses on genetic basis, non-coding RNA, and animal models to uncover pathogenesis and potential treatment targets. Despite recent advances, understanding gene regulatory networks and exploring therapies remain critical for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xue Jiao, Tingting Meng, Yiwei Zhai, Lijuan Zhao, Wei Luo, Peihao Liu, Yingying Qin
Summary: Ovarian reserve indicators deteriorate with the progression of ovarian insufficiency, with an increase in FSH and LH but a decrease in AMH, inhibin B, AFC, E-2 and T. AMH has the highest predictive value for POI, and the combination of AMH and AFC is promising for early prediction. Significant differences exist in hormone status among women with different etiologies of POI, with genetic POI showing the worst hormone status.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Linlin Liu, Huasong Wang, Guo Liang Xu, Lin Liu
Summary: Tet enzymes, specifically Tet1, are crucial for DNA demethylation and have a significant impact on stem cell differentiation and pluripotency. The deficiency of Tet1 can lead to accelerated reproductive failure due to decreased follicle reserve and other molecular changes in oocytes, indicating a potential link to premature ovarian failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Oncology
Fabiana Conciatori, Erica Salvati, Ludovica Ciuffreda, Senji Shirasawa, Italia Falcone, Francesco Cognetti, Gianluigi Ferretti, Massimo Zeuli, Donatella Del Bufalo, Chiara Bazzichetto, Michele Milella
Summary: Soluble factors produced by stromal fibroblasts can influence the sensitivity of tumor cells to molecularly targeted drugs. This influence depends on the genetic mutations and PTEN protein status of the tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Wenjing Zheng, Karen Ocorr, Marc Tatar
DISEASE MODELS & MECHANISMS
(2020)
Article
Psychiatry
Mehala Subramaniapillai, Rodrigo B. Mansur, Yan Chen, Orly Lipsitz, Roger S. McIntyre, Elisa Brietzke, Weicong Lu, Qingzhe Miao, Yanling Gao, Kun Chen, Yanan Bi, Wenjing Zheng, Guiyun Xu, Kangguang Lin
JOURNAL OF PSYCHIATRIC RESEARCH
(2020)
Article
Psychiatry
Kangguang Lin, Brendon Stubbs, Wenjin Zou, Wenjing Zheng, Weicong Lu, Yanling Gao, Kun Chen, Shengli Wang, Jie Liu, Yanxiong Huang, Lijie Guan, Mabel Ngai Kiu Wong, Runhua Wang, Bess Yin-Hung Lam, Guiyun Xu
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Clinical Neurology
Dongyan Wu, Feiyan Chang, Dantao Peng, Sheng Xie, Xiaoxuan Li, Wenjing Zheng
Review
Environmental Sciences
Zhenjie Wang, Mengmeng Xu, Yanhua Wang, Ting Wang, Nan Wu, Wenjing Zheng, Huawei Duan
Summary: The study investigated the impact of PM exposure on surfactant proteins, finding a significant decrease in circulating SP-D and an increase in serum SP-A among smokers. These results suggest that circulating surfactant proteins may serve as biomarkers for respiratory injury caused by air particulate matter.
Article
Clinical Neurology
Dingjun Hao, Jinpeng Du, Liang Yan, Baorong He, Xiao Qi, Shicheng Yu, Jiaojiao Zhang, Wenjing Zheng, Rongqiang Zhang, Da-Geng Huang, Junsong Yang, Ming Zhu, Jiawei Ouyang, He Zhao, Keyuan Ding, Haodong Shi, Yang Cao, Ying Zhang, Qinghua Tang, Yuan Liu, Zilong Zhang, Yuhang Wang, Ye Tian, Hao Chen, Lulu Bai, Heng Li, Chenchen Mu, Youhan Wang, Xiaohui Wang, Chao Jiang, Jianhua Lin, Bin Lin, Shunwu Fan, Lin Nie, Jiefu Song, Xun Ma, Zengwu Shao, Yanzheng Gao, Zhong Guan, Yueming Song, Weihu Ma, Qixin Chen
Summary: The incidence of TSCI in China significantly increased from 2009 to 2018, especially among the elderly population. The mortality rate of TSCI patients in hospitals is relatively low, but elderly individuals remain at a high risk of hospital death.
EUROPEAN SPINE JOURNAL
(2021)
Review
Obstetrics & Gynecology
Roger J. Hart, Thomas D'Hooghe, Eline A. F. Dancet, Ramon Aurell, Bruno Lunenfeld, Raoul Orvieto, Antonio Pellicer, Nikolaos P. Polyzos, Wenjing Zheng
Summary: Most fertility specialists routinely conduct hormone monitoring during medically assisted reproduction (MAR), but blood tests may cause inconvenience to patients. Remote urine-based hormonal monitoring could be a potential alternative to current serum-based testing, reducing the inconvenience of blood tests for patients.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yun-Tao Zhao, Haowen Yin, Chuanyin Hu, Jian Zeng, Xinyi Shi, Shaohong Chen, Kun Zhang, Wenjing Zheng, Wenjin Wu, Shucheng Liu
Summary: TSP has protective effects on POF in mice by alleviating ovarian oxidative stress and granulosa cell apoptosis.
Article
Nutrition & Dietetics
Yun-Tao Zhao, Haowen Yin, Chuanyin Hu, Jian Zeng, Shilin Zhang, Shaohong Chen, Wenjing Zheng, Mengjiao Li, Leigang Jin, You Liu, Wenjin Wu, Shucheng Liu
Summary: This study investigated the effects of tilapia skin peptides (TSP) on anxiety- and depression-like behavior in mice induced by chemotherapy. The results showed that TSP improved oxidative stress, neuroinflammation, neuron apoptosis, and neurogenesis in the hippocampus of mice, thus restoring the abnormal changes.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Qingyu Liu, Yuan Li, Siying Wang, Wenjing Zheng, Han Ye, Wen Li, Tong Qiao
Summary: The purpose of this study was to compare the differences of V-pattern exotropia in craniosynostosis and normal children. The study found that the craniosynostosis group had larger deviation, more pronounced V-pattern exotropia, and more severe inferior oblique overaction compared to the control group. Additionally, the lateral recession and anterior transposition in the craniosynostosis group were larger than in the control group. The craniosynostosis group also had a significant increase in extraocular muscle abnormalities compared to the control group.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Multidisciplinary
Wenjing Zheng, Rassamee Chotipanvithayakul, Thammasin Ingviya, Xiaoling Xia, Lu Xie, Jin Gao
Summary: This study suggests that integrated sensory stimulation has a positive impact on social-emotional development, temperament, and length for preterm infants.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, Research & Experimental
Yi Huo, Han Zhang, Longqi Sa, Wenjing Zheng, Yang He, Haohan Lyu, Mengjie Sun, Lingling Zhang, Lequn Shan, Angang Yang, Tao Wang
Summary: This study developed a novel HER2-targeting CAR-M and demonstrated that M1 polarization enhanced the immune activity of CAR-M, resulting in effective elimination of HER2-positive tumor cells both in vitro and in vivo. This finding suggests that M1-polarized CAR-M has the potential to become a stronger therapeutic approach in solid cancer immunotherapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Wenjing Zheng, Le Gao, Yanna Fan, Chunyan Wang, Yanqing Liu, Fei Tian, Min Yi, Xiaobo Peng, Chunzi Liu
Summary: This study aims to uncover potential risk factors associated with self-poisoning suicide and provide a reliable nomogram to predict self-poisoning suicide among poisoned patients. After analyzing 237 patients, it was found that gender, smoking, generalized anxiety disorder-7 (GAD-7), and beck hopelessness scale-20 (BHS-20) were significant risk factors. A nomogram was developed to facilitate the use of the prediction model by researchers.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Zheng Wen Jing, Yao Hong Yan, Liu Jian Jun, Yu Shi Cheng
Summary: A preliminary subjective evaluation scale was developed to assess the built environments of China's Hygienic City Initiative, demonstrating high reliability and validity. The scale consists of five dimensions and 22 items, covering urban lifestyle, governance, basic functions, environmental sanitation, and amenities. The Cronbach's α coefficient was 0.876, indicating a high level of internal consistency.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yun-Tao Zhao, Lulu Zhang, Haowen Yin, Ling Shen, Wenjing Zheng, Kun Zhang, Jian Zeng, Chuanyin Hu, You Liu
Summary: In a mouse model of depressive-like behavior induced by chronic unpredictable mild stress (CUMS), Hydroxytyrosol (HT) significantly improved depressive symptoms by alleviating oxidative stress and neuroinflammation, and enhancing the BDNF/TrkB/CREB signaling pathway.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
