Review
Endocrinology & Metabolism
Jonathan Wolf Mueller, Nora Vogg, Thomas Alec Lightning, Isabel Weigand, Cristina L. Ronchi, Paul A. Foster, Matthias Kroiss
Summary: The adrenal cortex produces specific steroid hormones including steroid sulfates, which may play a role in the pathophysiology of adrenal tumors and serve as potential biomarkers. Recent analytical developments may target sulfated steroids specifically.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Paul A. Foster
Summary: The research on STS inhibitors has made significant progress over the past 30 years, contributing to our understanding of sulphate biology and treatment of hormone-dependent diseases. Several effective inhibitors have been developed and shown promising therapeutic effects in various cancers and other conditions.
Review
Oncology
Matti Poutanen, Malin Hagberg Thulin, Pirkko Harkonen
Summary: This review highlights the importance of inhibiting sex steroid biosynthesis to restrict their availability for receptor binding in the treatment of breast and prostate cancers. It discusses current therapies and potential new targets and mechanisms for more efficient treatment.
NATURE REVIEWS CANCER
(2023)
Review
Oncology
Matti Poutanen, Malin Hagberg Thulin, Pirkko Harkonen
Summary: Sex steroids are major promoters of breast and prostate cancer growth. Current treatment methods include inhibiting sex steroid biosynthesis and blocking sex steroid receptor interactions. Enzyme inhibitors have been developed, but there is still potential for discovering new targets and mechanisms for more effective therapies.
NATURE REVIEWS CANCER
(2023)
Article
Biochemistry & Molecular Biology
Pei-Fang Chiu, I-Chun Lin, Yeh-Lin Lu, Chiao-Nien Chang, Hui-Yu Chan, Tzung-Shen Lin, Keng-Chang Tsai, Yves S. Y. Hsieh, Mei-Jou Chen, Mei-Hsiang Lin, Pi-Hui Liang
Summary: Inhibition of steroid sulfatase (STS) can decrease estrogen production, thereby suppressing tumor proliferation. In this study, twenty-one tricyclic and tetraheterocyclic coumarin-based derivatives were explored and evaluated for their STS enzyme kinetic parameters, docking models, and cytotoxicity towards breast cancer and normal cells. The tricyclic derivative 9e and tetracyclic derivative 10c were found to be the most promising irreversible inhibitors, with K-I values of 0.05 and 0.4 nM, and k(inact)/K-I ratios of 28.6 and 19.1 nM(-1)min(-1) on human placenta STS, respectively.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chiao-Nien Chang, I-Chun Lin, Tzung-Sheng Lin, Pei -Fang Chiu, Yeh-Lin Lu, Manmath Narwane, I-Chen Liu, Yue Hng, Keng-Chang Tsai, Mei-Hsiang Lin, Yves S. Y. Hsieh, Mei-Jou Chen, Pi-Hui Liang
Summary: The study focuses on the synthesis and evaluation of compound inhibitors for steroid sulfatase, which showed that the introduction of chlorine substitution enhanced the inhibition of STS. The kinetic analysis revealed the high efficiency of irreversible inhibition for chloride-bearing compounds. The selected compounds also demonstrated safety and anticancer activity.
BIOORGANIC CHEMISTRY
(2022)
Review
Oncology
Chandra K. Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nicholas Borcherding, Praveen Vikas, Weizhou Zhang
Summary: The oncogenic role of estrogen receptor (ER) signaling in breast cancer is well-established. Aberrant estrogen signaling enhances mammary epithelial cell proliferation, survival, and angiogenesis, contributing to breast cancer initiation and progression. Estrogen has been found to have both pro- and anti-inflammatory roles, and xenoestrogens can modulate chronic inflammation and breast cancer development. Understanding the complex relationship between estrogens, inflammation, and breast cancer will inform clinical research on prevention and therapy.
Review
Oncology
Ann E. Drummond, Christopher T. Swain, Kristy A. Brown, Suzanne C. Dixon-Suen, Leonessa Boing, Eline H. van Roekel, Melissa M. Moore, Tom R. Gaunt, Roger L. Milne, Dallas R. English, Richard M. Martin, Sarah J. Lewis, Brigid M. Lynch
Summary: Through a systematic review and meta-analysis, this study found that circulating sex steroid hormones have different effects on breast cancer risk in pre- and postmenopausal women. In premenopausal women, there was little evidence of an association, while in postmenopausal women, higher levels of estrogens and androgens were associated with increased risk, while higher levels of SHBG were associated with decreased risk. These findings suggest a plausible role for sex steroid hormones in mediating the causal relationship between physical activity and breast cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, Research & Experimental
Yelda A. Leal, Minkyo Song, Jovanny Zabaleta, Gilberto Medina-Escobedo, Patrick Caron, Aurelio Lopez-Colombo, Chantal Guillemette, M. Constanza Camargo
Summary: The study suggests that higher levels of circulating DHEA may be associated with a lower risk of noncardia gastric cancer, while estradiol and testosterone levels were not significantly linked to gastric cancer. Further longitudinal studies are needed to explore the temporality of this association and the mechanisms of disease pathogenesis.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Adele Vivacqua
Summary: Breast cancer is a major health concern for women worldwide, with its molecular pathogenesis still unclear. GPER1 and miRNAs play vital roles in breast cancer, influencing tumor development by regulating gene expression levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Hanan S. Anbar, Zahraa Isa, Jana J. Elounais, Mariam A. Jameel, Joudi H. Zib, Aya M. Samer, Aya F. Jawad, Mohammed El-Gamal
Summary: The STS enzyme plays a crucial role in the metabolism of steroid sex hormones and is associated with the pathophysiology of certain diseases. Successful STS inhibitor candidates like Irosustat have shown promise in treating specific cancers and neurodegenerative disorders, with reduced estrogenic side effects. Dual-acting molecules that inhibit STS and another synergistic mechanism may offer therapeutic efficiency.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2021)
Article
Biochemistry & Molecular Biology
Rocio Alejandra Ruiz Manzano, Karen Elizabeth Nava-Castro, Margarita Isabel Palacios-Arreola, Rosalia Hernandez-Cervantes, Victor Hugo Del Rio-Araiza, Mariana Segovia-Mendoza, Armando Perez-Torres, Manuel Ivan Giron-Perez, Jorge Morales-Montor
Summary: Breast cancer treatment failure is related to low response rates, high costs, and long-term toxicities. The study found that the androstene-3 beta, 17 alpha-diol (alpha-AED) has potential as a less toxic and effective treatment for triple-negative mammary tumors. In vitro experiments showed that higher doses of alpha-AED have an antiproliferative effect on tumor cells. In vivo experiments demonstrated that intratumoral administration of alpha-AED reduced tumor weight and increased the percentage of natural killer cells in mice tumors. These findings suggest that alpha-AED may be a promising alternative or adjunct therapy for breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Karolina Hanusek, Jakub Karczmarski, Anna Litwiniuk, Katarzyna Urbanska, Filip Ambrozkiewicz, Andrzej Kwiatkowski, Lidia Martynska, Anita Domanska, Wojciech Bik, Agnieszka Paziewska
Summary: Obesity is associated with an increased risk of breast cancer through mechanisms involving inflammation, cell metabolism disorders, and hormonal metabolism disturbances. MicroRNAs may play a role in regulating these processes and could serve as potential biomarkers and targets for anti-cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Dehong Li, Seyed-Omar Zaraei, Rawan M. Sbenati, Anil Ravi, Yingjie Wen, Lingda Zeng, Jiali Wang, Mohammed I. El-Gamal, Hanhong Xu
Summary: A study found that inhibiting the glucosinolate-myrosinase system in Plutella xylostella can effectively control its feeding on Brassicaceae plants. By synthesizing sulfamate derivatives as novel inhibitors, Adam-20-S was identified as the most potent GSS inhibitor. The study demonstrated that inhibiting GSS activity hindered the growth and development of P. xylostella.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Emmanuel Stephen Odinga, Xian Zhou, Evance Omondi Mbao, Qurban Ali, Michael Gatheru Waigi, Margaret L. Shiraku, Wanting Ling
Summary: This study conducted a comprehensive bibliometric analysis of research on steroidal estrogens (SEs) in the past two decades. It revealed that SEs are widespread in surface waters and natural SEs are the most studied, while research on SEs in soils, groundwater, and sediments is limited. The findings provide valuable insights for future monitoring, management, and risk assessment.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)