Review
Biochemistry & Molecular Biology
Gioacchino Natoli, Francesco Pileri, Francesco Gualdrini, Serena Ghisletti
Summary: Macrophages respond to microbial and endogenous danger signals by activating various effector and homeostatic responses. This involves rapid changes in gene expression programs and metabolic rewiring, with chromatin modifications integrating transcriptional and metabolic regulation. The mutual influences between signal-induced metabolic changes and gene expression are not fully understood yet, and further research is needed to explore these interactions.
Review
Chemistry, Multidisciplinary
Yuchen Zhang, Emily Ming-Chieh Lu, David Moyes, Sadia Ambreen Niazi
Summary: This systematic review evaluates the impact of peri-implantitis on metabolic syndrome and provides management suggestions for patients with metabolic disorders. The findings suggest an association between peri-implantitis and altered metabolic factors, including lipid profile and HbA1c level. However, more high-quality studies are needed to confirm these results.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Mathilde Foisy Sauve, Francis Feldman, Mireille Koudoufio, Nour-El-Houda Ould-Chikh, Lena Ahmarani, Alain Sane, Thierry N'Timbane, Ramy El-Jalbout, Nathalie Patey, Schohraya Spahis, Alain Stintzi, Edgard Delvin, Emile Levy
Summary: This study demonstrated that glycomacropeptide (GMP) has the potential to reduce systemic insulin resistance, decrease oxidative stress and inflammation, enhance antioxidant enzyme expression in the liver, and inhibit hepatic inflammatory response, leading to improved hepatic insulin sensitivity and restoration of liver homeostasis.
Review
Biology
Zhongjie Fu, Anders K. Nilsson, Ann Hellstrom, Lois E. H. Smith
Summary: Retinopathy of prematurity (ROP) is caused by the suppression of physiological retinal vascular development, leading to compensatory but pathological neovascularization. Promoting normal vessel growth can prevent ROP. Early perinatal metabolic dysregulation is a risk factor for ROP and other long-term sequelae. Controlling postnatal hyperglycemia, dyslipidemia, and hyperoxia can promote normal retinal development.
Article
Agriculture, Dairy & Animal Science
Yue Feng, Yanlin Li, Wenduo Jiang, Yun Hu, Yimin Jia, Ruqian Zhao
Summary: This study found that laying hens fed a HELP diet exhibited excess lipid accumulation and activation of lipogenic genes in the liver, accompanied by increased GR expression and global m(6)A demethylation. The m(6)A demethylase FTO was upregulated, while the m(6)A reader YTHDF2 was downregulated in the liver of FLS chickens. Specific demethylation of m(6)A in the mRNA of lipogenic genes was identified, with GR binding to the FTO gene promoter enriched and GR binding to the YTHDF2 gene promoter diminished.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Paniz Attarian, Nader Mokhtarani
Summary: This study compared aerobic biodegradation of MTBE and its intermediate products through a microbial consortium obtained from municipal wastewater sludge by co-metabolism and direct metabolism. Both metabolisms showed good performance in degrading MTBE and its intermediate products, but direct metabolism exhibited better system stability and shock loading resistance.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Review
Cell Biology
M. Eugenia Delgado, Beatriz I. Cardenas, Nuria Farran, Mercedes Fernandez
Summary: This article summarizes the main components and mechanisms involved in the progression of liver fibrosis, with a special focus on the metabolic regulation of key effectors such as hepatic stellate cells (HSCs). It also discusses the role of RNA-binding proteins (RBPs) in the post-transcriptional regulation that affects the progression of fibrosis and chronic liver diseases (CLD).
Article
Biochemistry & Molecular Biology
Emanuele Durante-Mangoni, Domenico Iossa, Valeria Iorio, Irene Mattucci, Umberto Malgeri, Daniela Pinto, Roberto Andini, Ciro Maiello, Rosa Zampino
Summary: Post-transplant diabetes mellitus (PTDM) is a common complication after heart transplant, sharing similarities with type 2 diabetes but also having specific causes. This study evaluated the incidence and risk factors of PTDM and studied its relationship with glucose metabolic alterations and heart transplant outcomes. The results showed that PTDM is closely related to BMI increase, metabolic syndrome development, and recipient survival.
Article
Cell Biology
Matthew A. Reyer, Shriram Chennakesavalu, Emily M. Heideman, Xiangqian Ma, Magda Bujnowska, Lu Hong, Aaron R. Dinner, Carin K. Vanderpool, Jingyi Fei
Summary: Small RNAs (sRNAs) are important gene regulators in bacteria, acting post-transcriptionally by affecting translation and degradation of target mRNAs. Some sRNAs can regulate targets co-transcriptionally early in an mRNA's lifetime, potentially mediated by Rho-dependent termination. Data also reveals that certain kinetic steps and sRNA binding to target mRNA may dictate the regulation hierarchy within sRNA regulons.
Article
Multidisciplinary Sciences
Elie Farhat, Giancarlo G. M. Talarico, Melissa Gregoire, Jean-Michel Weber, Jan A. Mennigen
Summary: This study demonstrates that components of the molecular oxygen-sensing machinery are robustly activated across tissues under chronic hypoxia, inducing repressive transcriptional and post-transcriptional epigenetic marks in the hypoxia-acclimated brain. Additionally, evidence supports the role of membrane remodeling and mitochondrial function in promoting metabolic suppression in goldfish.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Yuhan Zhang, Liuhua Shi, Howard Chang, Joel Schwartz, Qian Di, Jack Goldberg, Viola Vaccarino
Summary: A study of 566 middle-aged twins found that higher PM2.5 values in the residence area are associated with more MetS risk factors, but this association is confounded by familial factors.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Maria Gavriatopoulou, Stavroula A. Paschou, Ioannis Ntanasis-Stathopoulos, Meletios A. Dimopoulos
Summary: Multiple myeloma is characterized by monoclonal proliferation of plasma cells in the bone marrow and cancer cells deregulate metabolic pathways to ensure their proliferation, survival, and avoid immune surveillance. Metabolic syndrome, inflammatory cytokines, and the use of metformin and statins have been associated with the incidence and prognosis of MM. Targeting dysregulated pathways in MM may enhance antitumor therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Fangying Shi, Chuwen Huang, Yuan Ren, Chunhui Deng, Nianrong Sun, Xizhong Shen
Summary: We designed a mesoporous superstructure with silicon atom-doped nanowire arrays uniformly loaded with Pt nanoparticles to efficiently extract high-quality metabolic fingerprints from only 35 nL of serum within seconds. Using machine learning algorithms, we established specific biomarker panels to distinguish different liver diseases with over 90% accuracy and identified key metabolites for discrimination with 100% sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Guozhu Ye, Xu Zhang, Xinyu Liu, Xu Liao, Han Zhang, Changzhou Yan, Yi Lin, Qiansheng Huang
Summary: The study found that exposure to polystyrene microplastics significantly altered the metabolism of marine medaka livers, leading to changes in various metabolic pathways and levels of specific metabolites. The effects of different sizes of microplastics (10-mu m and 200-mu m) on hepatic metabolism were observed, with differences in the impact on carbohydrate, amino acid, and lipid metabolism. Overall, the results provide new insights into the ecotoxicology of microplastics in aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Oncology
Parmanand Malvi, Vipin Rawat, Romi Gupta, Narendra Wajapeyee
Summary: Metabolic reprogramming, characterized by the overexpression of metabolic enzymes, is a key feature of cancer cells. This study focuses on lactate dehydrogenase (LDHA) as an overexpressed enzyme in various cancer types, including pancreatic ductal adenocarcinoma (PDAC), and its role in promoting cancer growth. The study models the adaptation of cancer cells to LDHA inhibition, specifically using the competitive LDHA inhibitor sodium oxamate. Through various molecular analyses, the study identifies significant differences in mRNA expression, chromatin accessibility, and metabolite levels between oxamate-resistant PDAC cells and parental cells. Furthermore, integrated analysis reveals changes in metabolic enzymes that contribute to the observed alterations in metabolites. This study provides insights into the transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor resistance in PDAC cells, and highlights the need for further functional studies to understand the mechanisms underlying this resistance and optimize the use of LDHA inhibitors in cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Dario A. Gutierrez, Sathya Muralidhar, Thorsten B. Feyerabend, Stephan Herzig, Hans-Reimer Rodewald
Article
Medicine, Research & Experimental
Christian Stoy, Aishwarya Sundaram, Marcos Rios Garcia, Xiaoyue Wang, Oksana Seibert, Annika Zota, Susann Wendler, David Maennle, Ulf Hinz, Carsten Sticht, Maria Muciek, Norbert Gretz, Adam J. Rose, Vera Greiner, Thomas G. Hofmann, Andrea Bauer, Joerg Hoheisel, Mauricio Berriel Diaz, Matthias M. Gaida, Jens Werner, Tobias Schafmeier, Oliver Strobel, Stephan Herzig
EMBO MOLECULAR MEDICINE
(2015)
Article
Endocrinology & Metabolism
M. Karbiener, C. Glantschnig, D. F. Pisani, J. Laurencikiene, I. Dahlman, S. Herzig, E-Z Amri, M. Scheideler
INTERNATIONAL JOURNAL OF OBESITY
(2015)
Article
Multidisciplinary Sciences
Dasa Medrikova, Tjeerd P. Sijmonsma, Katharina Sowodniok, David M. Richards, Michael Delacher, Carsten Sticht, Norbert Gretz, Tobias Schafmeier, Markus Feuerer, Stephan Herzig
Article
Genetics & Heredity
Yong-Sheng Cheng, Oksana Seibert, Nora Kloeting, Arne Dietrich, Katrin Strassburger, Sonia Fernandez-Veledo, Joan J. Vendrell, Antonio Zorzano, Matthias Blueher, Stephan Herzig, Mauricio Berriel Diaz, Aurelio A. Teleman
Article
Endocrinology & Metabolism
Juergen G. Okun, Sean Conway, Kathrin V. Schmidt, Jonas Schumacher, Xiaoyue Wang, Roldan de Guia, Annika Zota, Johanna Klement, Oksana Seibert, Achim Peters, Adriano Maida, Stephan Herzig, Adam J. Rose
MOLECULAR METABOLISM
(2015)
Article
Endocrinology & Metabolism
Yang Jiang, Adam J. Rose, Tjeerd P. Sijmonsma, Angelika Broeer, Anja Pfenninger, Stephan Herzig, Dieter Schmoll, Stefan Broeer
MOLECULAR METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Rayane A. Ghandour, Maude Giroud, Alexandros Vegiopoulos, Stephan Herzig, Gerard Ailhaud, Ez-Zoubir Amri, Didier F. Pisani
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Medicine, Research & Experimental
Jessica Fuhrmeister, Annika Zota, Tjeerd P. Sijmonsma, Oksana Seibert, Sahika Cingir, Kathrin Schmidt, Nicola Vallon, Roldan M. de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blueher, Juergen G. Okun, Stephan Herzig, Adam J. Rose
EMBO MOLECULAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vanessa Stahl, Florian Maier, Martin T. Freitag, Ralf O. Floca, Moritz C. Berger, Reiner Umathum, Mauricio Berriel Diaz, Stephan Herzig, Marc-Andre Weber, Antonia Dimitrakopoulou-Strauss, Kristian Rink, Peter Bachert, Mark E. Ladd, Armin M. Nagel
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Article
Biochemistry & Molecular Biology
Yuuta Fujikawa, Leticia P. Roma, Mirko C. Sobotta, Adam J. Rose, Mauricio Berriel Diaz, Giuseppe Locatelli, Michael O. Breckwoldt, Thomas Misgeld, Martin Kerschensteiner, Stephan Herzig, Karin Mueller-Decker, Tobias P. Dick
Article
Multidisciplinary Sciences
Jeremie Gautheron, Mihael Vucur, Anne T. Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald, Ulf P. Neumann, Frank Tacke, Christian Trautwein, Douglas R. Green, Thomas Longerich, Norbert Frey, Mark Luedde, Matthias Bluher, Stephan Herzig, Mathias Heikenwalder, Tom Luedde
NATURE COMMUNICATIONS
(2016)
Article
Endocrinology & Metabolism
Markus Wortmann, Maani Hakimi, Thomas Fleming, Andreas S. Peters, Tjeerd P. Sijmonsma, Stephan Herzig, Peter P. Nawroth, Dittmar Boeckler, Susanne Dihlmann
JOURNAL OF DIABETES RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Yuuta Fujikawa, Leticia P. Roma, Mirko C. Sobotta, Adam J. Rose, Mauricio Berriel Diaz, Giuseppe Locatelli, Michael O. Breckwoldt, Thomas Misgeld, Martin Kerschensteiner, Stephan Herzig, Karin Mueller-Decker, Tobias P. Dick
Article
Endocrinology & Metabolism
Michaela Schaefer, Christian U. Oeing, Maria Rohm, Ezgi Baysal-Temel, Lorenz H. Lehmann, Ralf Bauer, H. Christian Volz, Michael Boutros, Daniela Sohn, Carsten Sticht, Norbert Gretz, Katrin Eichelbaum, Tessa Werner, Marc N. Hirt, Thomas Eschenhagen, Karin Mueller-Decker, Oliver Strobel, Thilo Hackert, Jeroen Krijgsveld, Hugo A. Katus, Mauricio Berriel Diaz, Johannes Backs, Stephan Herzig
MOLECULAR METABOLISM
(2016)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)