Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Article
Biochemistry & Molecular Biology
Chaitra Rai, C. D. Nandini, Poornima Priyadarshini
Summary: The study demonstrated the anti-adipogenic activity of bovine milk Glycosaminoglycans (bmGAGs) by modulating adipogenesis-related marker proteins, suggesting a potential therapeutic use of bmGAGs in the management of obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sara Ellegaard Christensen, Liv Norma Smith, Christian Alexander H. Rosendal, Helga Angela Gulisano, Kare Schmidt Ettrup, Peter Vestergaard, Eigil Husted Nielsen, Jesper Scott Karmisholt, Jakob Dal
Summary: The value of the TRH test in diagnosing CH in patients with pituitary disease was evaluated. Patients diagnosed with CH had lower T4(corr) and TSH increase compared to patients without CH. In some patients with low T4(corr), the CH diagnosis was rejected, and a spontaneous increase in T4(corr) was observed during follow-up. CH patients reported more symptoms of hypothyroidism. The TRH test did not provide relevant clinical information in patients with normal T4 or patients awaiting pituitary surgery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Jiyoung Bae, Yang Yang, Xinyun Xu, Jamie Flaherty, Haley Overby, Kelsey Hildreth, Jiangang Chen, Shu Wang, Ling Zhao
Summary: Identifying functional brown adipose tissue (BAT) has provided new hope for obesity treatment and prevention. The study found that naringenin (NAR) can promote adipocyte browning and thermogenesis through the activation of PPARγ.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xingren Chen, Xiaobo Zhu, Jian Dong, Fang Chen, Qi Gao, Lijun Zhang, Dawei Cai, Hui Dong, Binjia Ruan, Yongxiang Wang, Qing Jiang, Wangsen Cao
Summary: The study demonstrates that diacerein has a significant protective effect on cartilage damage in OA mice, by inhibiting the upregulation of DNMT1/3a, promoter hypermethylation of PPAR gamma, and reversing the expression of antioxidant enzymes and inflammatory cytokines.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaojing Zhang, Baoyi Zhu, Peibin Lin, Xiaoping Liu, Jun Gao, Dazhong Yin, Jianwen Zeng, Baojian Liao, Zhanfang Kang
Summary: This study found that niacin treatment can increase lipotoxicity in beta cells of diabetic patients through the upregulation of GPR109A and PPARγ2. However, this toxicity can be alleviated by incretin drugs. Furthermore, the combination of niacin and incretin drugs may have better effects on blood glucose and lipid control in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Review
Biochemistry & Molecular Biology
Elena Alvarez-Salas, Cinthia Garcia-Luna, Patricia de Gortari
Summary: Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis and acts as a neuromodulator of various behaviors. It has potential neuroprotective and mood-improving effects, but its limited permeability and degradation have restricted its therapeutic actions. However, new delivery strategies like intranasal delivery have renewed interest in TRH. TRH analogs have been proven safe and effective, and efforts are being made to prolong and facilitate their actions for better symptom management and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Yongyan Song, Shujin Li, Chuan He
Summary: Activated by ligands, PPAR gamma plays a role in enhancing insulin sensitivity, promoting adipocyte differentiation, and possessing anti-atherosclerosis, anti-inflammation, and anti-oxidation properties. Polymorphisms in the PPARG gene have been associated with coronary artery disease, possibly through affecting PPARG gene expression and PPAR gamma protein function, leading to metabolic disorders and increased susceptibility to CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Marco Antonio Parra-Montes De Oca, Israim Sotelo-Rivera, Angelica Gutierrez-Mata, Jean-Louis Charli, Patricia Joseph-Bravo
Summary: The hypothalamus-pituitary-thyroid-axis (HPT) is an important neuroendocrine axis that regulates energy expenditure, with its activity modulated by factors such as sex, nutritional status and stress. Sex differences may be influenced by sex steroid concentrations and sex chromosomes, impacting the expression of relevant genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Catarina Teixeira, Andre P. Sousa, Ines Santos, Ana Catarina Rocha, Ines Alencastre, Ana Claudia Pereira, Daniela Martins-Mendes, Pedro Barata, Pilar Baylina, Ruben Fernandes
Summary: This study demonstrates that pioglitazone enhances adipocyte differentiation and secretome production, making it an excellent model for studying adiposity. The study also proposes an improved method for adipocyte secretome production, which can be used for experimental biology studies to understand the molecular mechanisms underlying the influence of adiposity on other cells.
Editorial Material
Endocrinology & Metabolism
Marie-Stephanie Clerget-Froidevaux, Laurent M. Sachs
Review
Biochemistry & Molecular Biology
Soumaya Kouidhi, Marie-Stephanie Clerget-Froidevaux
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Endocrinology & Metabolism
Soumaya Kouidhi, Rym Berrhouma, Kamel Rouissi, Slim Jarboui, Marie-Stephanie Clerget-Froidevaux, Isabelle Seugnet, Fattouma Bchir, Barbara Demeneix, Hajer Guissouma, Amel Benammar Elgaaied
ACTA DIABETOLOGICA
(2013)
Article
Endocrinology & Metabolism
Soumaya Kouidhi, Rym Berhouma, Myriam Ammar, Kamel Rouissi, Slim Jarboui, Marie-Stephanie Clerget-Froidevaux, Isabelle Seugnet, Hafawa Abid, Fattouma Bchir, Barbara Demeneix, Hajer Guissouma, Amel Benammar Elgaaied
ENDOCRINE RESEARCH
(2013)
Review
Endocrinology & Metabolism
J. Bowers, J. Terrien, M. S. Clerget-Froidevaux, J. D. Gothie, M. P. Rozing, R. G. J. Westendorp, D. van Heemst, B. A. Demeneix
Article
Endocrinology & Metabolism
J. B. Fini, S. Le Mevel, K. Palmier, V. M. Darras, I. Punzon, S. J. Richardson, M. S. Clerget-Froidevaux, B. A. Demeneix
Article
Endocrinology & Metabolism
S. Kouidhi, S. Jarboui, R. Marrakchi, M. -S. Clerget Froidevaux, I. Seugnet, H. Abid, F. Bchir, M. Brahem, B. Demeneix, H. Guissouma, A. Benammar Elgaaied
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2011)
Article
Cell Biology
Stephanie Decherf, Isabelle Seugnet, Nathalie Becker, Barbara A. Demeneix, Marie-Stephanie Clerget-Froidevaux
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2013)
Article
Multidisciplinary Sciences
Hajer Guissouma, Rym Ghaddab-Zroud, Isabelle Seugnet, Stephanie Decherf, Barbara Demeneix, Marie-Stephanie Clerget-Froidevaux
Article
Multidisciplinary Sciences
Rym Ghaddab-Zroud, Isabelle Seugnet, Knut R. Steffensen, Barbara A. Demeneix, Marie-Stephanie Clerget-Froidevaux
Article
Medicine, Research & Experimental
Sylvie Remaud, Silvia Alejandra Lopez-Juarez, Anne-Laure Bolcato-Bellemin, Patrick Neuberg, Fabrice Stock, Marie-Elise Bonnet, Rym Ghaddab, Marie Stephanie Clerget-Froidevaux, Jacqueline Pierre-Simons, Patrick Erbacher, Barbara A. Demeneix, Ghislaine Morvan-Dubois
MOLECULAR THERAPY-NUCLEIC ACIDS
(2013)
Article
Multidisciplinary Sciences
Jeremy Terrien, Isabelle Seugnet, Bolaji Seffou, Maria J. Herrero, James Bowers, Lamis Chamas, Stephanie Decherf, Evelyne Duvernois-Berthet, Chakib Djediat, Bertrand Ducos, Barbara A. Demeneix, Marie-Stephanie Clerget-Froidevaux
SCIENTIFIC REPORTS
(2019)
Review
Rheumatology
Camille Deprouw, Alice Courties, Jean-Baptiste Fini, Marie-Stephanie Clerget-Froidevaux, Barbara Demeneix, Francis Berenbaum, Jeremie Sellam, Karine Louati
Summary: This systematic literature review (SLR) summarizes existing knowledge on the associations between osteoarthritis (OA) and pollutants. Epidemiological studies suggest a possible link between chlorinated and fluorinated pollutants and OA. Higher serum lead levels are associated with increased prevalence of radiographic knee OA. Ex vivo studies found high concentrations of heavy metals in the cartilage tidemark. In vitro experiments showed reduced viability of chondrocytes in the presence of some pollutants. However, further methodologically sound studies are needed to confirm the role of pollutants as risk factors for OA.
Article
Biochemistry & Molecular Biology
Lamis Chamas, Isabelle Seugnet, Roseline Poirier, Marie-Stephanie Clerget-Froidevaux, Valerie Enderlin
Summary: This study investigated the protective mechanisms linking hypothyroidism and neuroinflammation. Hypothyroid WSB/EiJ mice showed no neuroinflammatory response and maintained hippocampal thyroid signaling despite low circulating thyroid hormone levels, while C57BL/6J mice exhibited disturbed thyroid signaling, accompanied by neuroinflammation and memory impairment. The results highlight the importance of the hippocampal thyroid regulatory system in glial reactivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Rheumatology
Camille Deprouw, Alice Courties, Jean-Baptiste Fini, Marie-Stephanie Clerget-Froidevaux, Barbara Demeneix, Francis Berenbaum, Jeremie Sellam, Karine Louati
ANNALS OF THE RHEUMATIC DISEASES
(2019)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
