Article
Physiology
Ahreum Kwon, Ji Young Eom, Woo Jung Lee, Han Saem Choi, Kyungchul Song, Junghwan Suh, Hyun Wook Chae, Ho-Seong Kim
Summary: The hypothalamic kisspeptin/KISS1 receptor system plays a vital role in puberty onset and reproductive development. This study identifies the ovaries as the main source of serum kisspeptin and suggests that serum kisspeptin levels are associated with pubertal development and dependent on ovarian Kiss1 expression. Serum kisspeptin may serve as a downstream marker of ovarian reproductive function.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Sheila J. Semaan, Alexander S. Kauffman
Summary: The mechanisms underlying puberty and sex differences in puberty onset remain unclear. This study compared hypothalamic gene expression changes during peri-puberty between male and female mice, revealing notable sex differences in kisspeptin and NKB neuron developmental patterns.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Review
Cell Biology
Xuehan Li, Chunyu Liang, Yi Yan
Summary: The Kiss1/GPR54 system plays a crucial role in regulating energy balance and metabolic homeostasis by controlling energy intake and expenditure balance, affecting insulin secretion, and influencing skeletal muscle function.
Article
Physiology
Viviane C. L. Gomes, Kalie F. F. Beckers, Kassandra R. R. Crissman, Camille A. A. Landry, Juliet P. P. Flanagan, Reham M. M. Awad, Fabio Del Piero, Chin-Chi Liu, Jenny L. L. Sones
Summary: Research has found that children born to women with preeclampsia show sex-specific changes in pubertal development, and expression of insulin-like growth factor 1 and its receptor in adipose tissue is also regulated by sex hormones. These findings suggest that preeclampsia has adverse reproductive effects on offspring, and these effects are associated with the hypertensive and metabolic phenotype of the BPH/5 mouse model.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shasha Zhou, Shaolian Zang, Yanping Hu, Yifen Shen, Hua Li, Wenlian Chen, Pin Li, Yihang Shen
Summary: This study investigated the gene expression patterns in different pubertal stages in the hypothalamus and identified a subset of kisspeptin neurons using a specific membrane surface biomarker. It was also found that different cell types in the hypothalamus have distinct functions in neurogenesis, hormone secretion, and estradiol response, contributing to the complex regulatory network of the hypothalamic-pituitary-gonadal axis.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Alessia Gloria, Alberto Contri, Elena Mele, Silvia Fasano, Riccardo Pierantoni, Rosaria Meccariello
Summary: The study found the presence of the Kisspeptin system in dog testis and spermatozoa, indicating a significant role of the system in sperm maturation and storage. The trafficking of Kiss1R towards the plasma membrane along the length of the epididymis and the presence of Kiss1 in epididymal fluid suggest a new functional role of the Kisspeptin system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Kai-Lun Hu, Zimiao Chen, Xiaoxue Li, Enci Cai, Haiyan Yang, Yi Chen, Congying Wang, Liping Ju, Wenhai Deng, Liangshan Mu
Summary: This article mainly introduces the role of kisspeptin in the hypothalamus and its potential applications in the treatment of female reproductive disorders, including regulation of ovulation and oocyte maturation. The article suggests that more clinical trials are needed to explore the therapeutic effects of kisspeptin, its receptor agonists, and antagonists in related diseases.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Vassos Neocleous, Pavlos Fanis, Meropi Toumba, Barbara Gorka, Ioanna Kousiappa, George A. Tanteles, Michalis Iasonides, Nicolas C. Nicolaides, Yiolanda P. Christou, Kyriaki Michailidou, Stella Nicolaou, Savvas S. Papacostas, Athanasios Christoforidis, Andreas Kyriakou, Dimitrios Vlachakis, Nicos Skordis, Leonidas A. Phylactou
Summary: The study identified three pathogenic MKRN3 variants and indicated a founder effect phenomenon for the most prevalent variant p.Gly312Asp exclusively found in the Cypriot CPP cohort. Additionally, rare likely pathogenic variants were found in other genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Daniel Cardoso, Rodolfo C. Cardoso, Guilherme de Paula Nogueira
Summary: This study demonstrates that GABA(A) antagonists have a stimulatory effect on LH secretion in pre-pubertal Nellore heifers, consistent with previous findings.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Endocrinology & Metabolism
Md. Mahiuddin Zahangir, Md. Shahjahan, Hironori Ando
Summary: Kisspeptin plays an important role in reproductive regulation in animals. In grass puffer, kisspeptin has different effects depending on the reproductive stage, and it mainly acts by regulating the expression of genes in the hypothalamic-pituitary-gonadal axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mahdi Golshan, Azadeh Hatef, Negar Kazori, Magdalena Socha, Miroslawa Sokolowska-Mikolajczyk, Hamid R. Habibi, Otomar Linhart, Sayyed Mohammad Hadi Alavi
Summary: This study reveals that exposure to bisphenol A (BPA) reduces sperm quality in goldfish and increases the levels of circulating LH and mRNA transcripts of upstream neuroendocrine regulators of reproduction.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
D. Franssen, A. Barroso, F. Ruiz-Pino, M. J. Vazquez, D. Garcia-Galiano, J. M. Castellano, R. Onieva, M. Ruiz-Cruz, M. Poutanen, F. Gaytan, C. Dieguez, L. Pinilla, M. Lopez, J. Roa, M. Tena-Sempere
Summary: Reproduction is closely linked to energy and metabolic status, with AMPK signaling in GnRH neurons playing a crucial role in metabolic control of the female reproductive axis, particularly during puberty and negative energy balance.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Endocrinology & Metabolism
Veronica Sobrino, Maria Soledad Avendano, Cecilia Perdices-Lopez, Manuel Jimenez-Puyer, Manuel Tena-Sempere
Summary: In late 2003, the identification of the reproductive roles of kisspeptins and Gpr54 led to a surge in research interest and established fundamental concepts in physiological roles of kisspeptins. This early knowledge set the stage for more recent in-depth studies on neuronal networks involving Kiss1 neurons and their regulation mechanisms.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Jaskamal Padda, Khizer Khalid, Amir Moosa, Mohammad Syam, Varsha Kakani, Urooj Imdad, Dina Ismail, Ayden Charlene Cooper, Gutteridge Jean-Charles
Summary: Kisspeptin, a neuropeptide encoded by the KISS1 gene, plays a significant role in human reproduction by acting on the HPG axis. It is vital for reproductive system maturation and function, puberty onset, sexual behavior, ovum and sperm development, and pregnancy, and is implicated in disorders like PCOS and infertility. Kisspeptin levels can also help identify pregnancy-related complications and research is exploring its potential as a diagnostic marker and treatment for reproductive disorders.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Andrology
Kyoung Huh, Won Heun Nah, Yang Xu, Mi Jung Park, Myung Chan Gye
Summary: Prepubertal rhGH treatment in male rats may induce early onset of puberty, sexual maturation, elevation of testosterone, and spermatogenesis, and accompanies downregulation of hypothalamic KISS1.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)