Article
Biochemistry & Molecular Biology
Ian-Arris de Bus, Antoine H. P. America, Norbert C. A. de Ruijter, Milena Lam, Jasper W. van de Sande, Mieke Poland, Renger F. Witkamp, Han Zuilhof, Michiel G. J. Balvers, Bauke Albada
Summary: This study investigated the mechanistic and biological origins of anti-inflammatory poly-unsaturated fatty acid-derived N-acylethanolamines using synthetic chemical probes. The results identified new molecular targets and suggested potential roles of DHEA and AEA in regulating reactive oxidation species, cell migration, cytoskeletal remodeling, and endosomal trafficking.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Analytical
Bingbing Zheng, Yang Tian, Senyao Liu, Jieyu Yang, Fapu Wu, Hu Xiong
Summary: Noninvasive visualization of liver polarity by using fluorescence imaging technology is achieved using a new cell membrane-targeted NIR small molecular probe (N-BPM-C ( 10 )). This probe exhibits polarity-dependent fluorescence and can rapidly light up cell membranes, making it useful for in vivo imaging studies. Importantly, it has been successfully applied to visualize liver polarity changes in DILI mice.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Xiangming Gu, Richard Hickey, Antara Rath, Andre F. Palmer
Summary: The goal of this study was to develop a novel manufacturing strategy for large-scale production of metHb. Small-scale screening experiments were conducted to determine the optimal molar ratio of Hb to oxidizing agents. The synthesized metHb showed stability and potential as a non-O-2 carrying control material.
Article
Cardiac & Cardiovascular Systems
James T. Miller, Casey G. Turner, Jeffrey S. Otis, Yesser Sebeh, Matthew J. Hayat, Arshed A. Quyyumi, Brett J. Wong
Summary: Our study found that inducible nitric oxide synthase (iNOS) plays a role in the reduced nitric oxide (NO)-dependent vasodilation in prehypertensive individuals and Black participants. Inhibition of iNOS can increase endothelial NO-dependent vasodilation in prehypertensive White participants and in both normotensive and prehypertensive Black participants.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatiana Lapina, Vladislav Statinov, Roman Puzanskiy, Elena Ermilova
Summary: The study demonstrates that colorless alga Polytomella parva cells synthesize nitric oxide (NO) through L-arginine and proposes the existence of a nitric oxide synthase-like activity independent of nitrate reductase (NR). The NO generated causes S-nitrosation of protein cysteine thiol groups as an essential post-translational modification in P. parva.
Article
Multidisciplinary Sciences
Hongyuan Zhang, Zhiqiang Zhao, Shengnan Sun, Sen Zhang, Yuequan Wang, Xuanbo Zhang, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: In this study, the authors developed a self-propelling nano-penetrator assembled with a photothermal photosensitizer and a photothermal-activable NO donor. The nano-penetrator showed advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models, it successfully navigated to thrombus, penetrated deep into the clot, and achieved effective thrombolysis and prevention of thrombosis recurrence and ischemic stroke.
NATURE COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Elizabeth C. Cottrell
Summary: Hypertension in pregnancy is common and poses risks for mothers and babies. Current treatments are limited, so new approaches are needed. Dietary nitrate supplementation has shown potential benefits for hypertension, but more research is needed.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Engineering, Environmental
Seung-Woon Baek, Da-Seul Kim, Jun-Kyu Lee, Jun Hyuk Kim, Semi Lee, Jeong Min Park, So-Yeon Park, Duck Hyun Song, Chun Gwon Park, Dong Keun Han
Summary: A novel nanoparticle with enhanced nitric oxide (NO) generating ability was synthesized to improve the biodegradable vascular scaffold (BVS) intervention for coronary artery diseases. The BVS containing the synthesized nanoparticles demonstrated potent functional recovery ability of unhealthy vessels by inhibiting platelet adhesion and activation, increasing endothelial cell proliferation, and decreasing smooth muscle cell proliferation. The BVS also showed scavenging ability of reactive oxygen species and inhibition of toxic NO production, with suppressed inflammatory response and induced healthy blood vessel formation when implanted in mice. This offers a new tool for designing cardiovascular stents and various biological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick A. Flume, Bryan A. Garcia, Dulaney Wilson, Lisa Steed, Susan E. Dorman, Kevin Winthrop
Summary: Patients with nontuberculous mycobacteria pulmonary disease (NTM-PD) tolerated a 3-week regimen of inhaled gas nitric oxide (gNO) without safety concerns. Among the participants, four individuals with highly refractory disease completed the study with negative cultures, although three of them tested positive again in subsequent months. These findings suggest that gNO could be further investigated as a potential therapy for NTM-PD.
RESPIRATORY MEDICINE
(2023)
Article
Plant Sciences
Xiugui Chen, Zhe Wu, Zujun Yin, Yuexin Zhang, Cun Rui, Jing Wang, Waqar Afzal Malik, Xuke Lu, Delong Wang, Junjuan Wang, Lixue Guo, Shuai Wang, Lanjie Zhao, Bobokhonova Zebinisso Qaraevna, Chao Chen, Xiuping Wang, Wuwei Ye
Summary: In this study, the authors conducted a genome-wide analysis of CAT genes in cotton and found that these genes play important roles in plant metabolic functions and response to abiotic stress. They found that the expression of GhCAT genes is induced by salt, drought, cold, and heat stresses, and the promoters of GhCAT genes contain responsive elements to plant hormones and abiotic stress. Silencing the expression of GhCAT10D decreased cotton's resistance to salt stress. These findings lay a foundation for further research on the regulation mechanism of CAT genes in cationic amino acid transport and distribution in response to abiotic stress.
Review
Biochemistry & Molecular Biology
Maria Rosaria Melis, Antonio Argiolas
Summary: Nitric oxide plays a crucial role in the central nervous system, regulating erectile function and sexual behavior by interacting with neurotransmitters. It acts not only in specific areas of the hypothalamus, but also in extrahypothalamic brain regions, contributing to a neural circuit controlling both consummatory and appetitive components of sexual behavior through interplay with various neurotransmitters.
Article
Environmental Sciences
Yu-Juan Lin, Xing-Hui Feng, Yu-Xi Feng
Summary: This study evaluated the importance of hydrogen sulfide (NaHS) and nitric oxide (SNP) in the antioxidant systems of rice seedlings under Cr(III) stress. The results showed that NaHS and SNP effectively alleviated the toxic effects of Cr(III) by activating different antioxidants. NaHS had a stronger regulatory effect on non-enzymatic and enzymatic antioxidants compared to SNP.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Naaman. M. M. Omar, Katherine Fleury, Brian Beardsall, Ondrej Prasil, Douglas. A. A. Campbell
Summary: Marine phytoplankton produce and scavenge Reactive Oxygen Species (ROS) to support cellular processes, but some prokaryotic picophytoplankton have lost genes encoding ROS scavenging. The allocation of genomic capacity for ROS metabolism varies with cell radius, with larger cells having decreased allocations for hydrogen peroxide production and scavenging. Nitric oxide production and scavenging are not influenced by cell radius, but the presence of these capacities is influenced by flagella and colony formation.
Article
Biochemistry & Molecular Biology
John Ukeri, Michael T. Wilson, Brandon J. Reeder
Summary: Cytoglobin has physiological roles that are not clearly understood, but may include regulation of nitric oxide, oxygen sensing, and protection against oxidative stress. Specific mutations can affect the nitric oxide binding and metabolism activities of cytoglobin, helping to understand its precise role under physiological and pathophysiological conditions.
Article
Oncology
Catherine G. Tran, Scott K. Sherman, Aaron T. Scott, Po Hien Ear, Chandrikha Chandrasekharan, Andrew M. Bellizzi, Joseph S. Dillon, Thomas M. O'Dorisio, James R. Howe
Summary: This study found that elevated levels of CgA, PST, and NKA during follow-up after surgery for SBNETs were associated with lower progression-free survival and overall survival, with PST demonstrating better discrimination of outcomes. Using PST most accurately detected disease progression during the follow-up period.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Aaron T. Scott, Jonathon B. Tessmann, Terry Braun, Bartley Brown, Patrick J. Breheny, Benjamin W. Darbro, Andrew M. Bellizzi, Joseph S. Dillon, Thomas M. O'Dorisio, Alice Alderson, Bonita Bennett, John A. Bernat, David C. Metz, James R. Howe
Summary: Currarino syndrome is a genetic syndrome caused by mutations in the MNX1 gene, characterized by anorectal abnormalities, partial sacral agenesis, and presacral masses. The presacral masses can be benign but may also have malignant degeneration, with reports of presacral neuroendocrine tumors in some cases. These cases highlight the variable presentation of the syndrome and the potential for malignancy in affected individuals.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2021)
Article
Oncology
Abhishek Jha, David Taieb, Jorge A. Carrasquillo, Daniel A. Pryma, Mayank Patel, Corina Millo, Wouter W. de Herder, Jaydira Del Rivero, Joakim Crona, Barry L. Shulkin, Irene Virgolini, Alice P. Chen, Bhagwant R. Mittal, Sandip Basu, Joseph S. Dillon, Thomas A. Hope, Carina Mari Aparici, Andrei H. Iagaru, Rodney J. Hicks, Anca M. Avram, Jonathan R. Strosberg, Ali Cahid Civelek, Frank I. Lin, Neeta Pandit-Taskar, Karel Pacak
Summary: This study aims to summarize the survival outcomes of available TRTs, discuss personalized treatment strategies based on functional imaging scans, address practical issues including regulatory approvals, and compare toxicities and risk factors across different treatments.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Catherine G. Tran, Scott K. Sherman, Mohammed O. Suraju, Apoorve Nayyar, Henning Gerke, Rami G. El Abiad, Chandrikha Chandrasekharan, Po Hien Ear, Thomas M. O'Dorisio, Joseph S. Dillon, Andrew M. Bellizzi, James R. Howe
Summary: The management of duodenal neuroendocrine tumors (DNETs) varies depending on the size of the lesion, with smaller ones typically treated by endoscopic mucosal resection (EMR) and larger ones by surgical resection (SR). A study comparing outcomes between patients who underwent EMR and SR showed that there was no significant difference in survival rates, particularly in 1-2 cm DNETs. However, surgically resected DNETs had improved progression-free survival (PFS) and overall survival (OS) compared to jejunoileal NETs.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tayde Quiroz-Acosta, Yazmin Montserrat Flores-Martinez, Elvia Becerra-Martinez, Elizabeth Perez-Hernandez, Nury Perez-Hernandez, Angel Ernesto Banuelos-Hernandez
Summary: Understanding the altered glycerophospholipid metabolism in giant cell tumor of bone (GCTB) may provide insights for developing prognostic markers and therapeutic targets. Through metabolomic analysis, sphingomyelin was identified as a dysregulated phospholipid in GCTB tissues, with high expression of sphingomyelin synthases 1 and 2 but low expression of neutral sphingomyelinase 2 (nSMase2).
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Delia Hernandez-Romero, Sharon Rosete-Luna, Aracely Lopez-Monteon, Aracely Chavez-Pina, Nury Perez-Hernandez, Jazmin Marroquin-Flores, Antonio Cruz-Navarro, Gustavo Pesado-Gomez, David Morales-Morales, Raul Colorado-Peralta
Summary: Cancer is characterized by irregular cell cycle function and uncontrolled cell growth. Chemotherapy is effective but often faces issues such as limited efficacy and drug resistance. Research on first-row transition metal compounds containing benzimidazole ligands may lead to the development of novel and potent metallodrugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Physical
Elvia Becerra-Martinez, Nury Perez-Hernandez, Pedro Joseph-Nathan
Summary: This study assigned the 750 MHz H-1 NMR spectra of two methyl acetylfusidates and revealed that ring B in these compounds exists in equilibrium between two twisted boat conformers through vibrational circular dichroism study. This finding will be useful for future docking calculations and specific pharmacological applications testing.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Editorial Material
Oncology
Luis C. Borbon, Catherine G. Tran, Scott K. Sherman, Po Hien Ear, Chandrikha Chandrasekharan, Andrew M. Bellizzi, Joseph S. Dillon, Thomas M. O'Dorisio, James R. Howe
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alicia Rodriguez-Pasten, Nury Perez-Hernandez, Javier Anorve-Morga, Ruben Jimenez-Alvarado, Raquel Carino-Cortes, Teresa Sosa-Lozada, Eduardo Fernandez-Martinez
Summary: Metabolic syndrome and hepatogastrointestinal diseases are influenced by lifestyle and diet, and their development is closely related to dysbiosis. Prebiotics, probiotics, and symbiotic complexes play a crucial role in regulating the immune system and carbohydrate and lipid metabolism, as well as improving dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Spectroscopy
Elvia Becerra-Martinez, Nury Perez-Hernandez, Maricruz Sanchez-Zavala, Myriam Melendez-Rodriguez, Alberto Aristeo-Dominguez, Oscar R. Suarez-Castillo, Pedro Joseph-Nathan
Summary: Accurate chemical shift and coupling constant for 1- and 2-naphthyl derivatives were determined using iterative full spin analysis and two-dimensional homo- and heteronuclear experiments. The complete proton nuclear magnetic resonance parameters are presented for the first time.
SPECTROSCOPY LETTERS
(2022)
Review
Oncology
Ioannis A. Ziogas, Panagiotis T. Tasoudis, Luis C. Borbon, Scott K. Sherman, Patrick J. Breheny, Chandrikha Chandrasekharan, Joseph S. Dillon, Andrew M. Bellizzi, James R. Howe
Summary: Surgical management may offer a potential survival benefit for G3 gastroenteropancreatic neuroendocrine neoplasms (GEP NENs), but further research is needed to determine which patients will benefit most from surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Ioannis A. Ziogas, Joseph S. Dillon, Chandrikha Chandrasekharan, James R. Howe
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Elizabeth Perez-Hernandez, Jesus Javier Pastrana-Carballo, Fernando Gomez-Chavez, Ramesh C. Gupta, Nury Perez-Hernandez
Summary: Taurine is a common ingredient in energy drinks and is naturally found in fish and other seafood. It is produced in the liver and can be obtained from food in humans. Taurine has various functions in target tissues such as the retina, heart, and skeletal muscle, including antioxidant, osmolyte, and antiapoptotic effects. It also plays a role in energy metabolism and calcium homeostasis. Taurine is important for bone growth and development, and recent studies have focused on its effects on osteoblastogenesis, osteoclastogenesis, bone structure, and bone pathologies.
ENDOCRINOLOGY AND METABOLISM
(2022)
Editorial Material
Oncology
Ioannis A. Ziogas, Panagiotis T. Tasoudis, Luis C. Borbon, Scott K. Sherman, Patrick J. Breheny, Chandrikha Chandrasekharan, Joseph S. Dillon, Andrew M. Bellizzi, James R. Howe
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Camilo Jimenez, Bennett B. Chin, Richard B. Noto, Joseph S. Dillon, Lilja Solnes, Nancy Stambler, Vincent A. DiPippo, Daniel A. Pryma
Summary: The objective of this study was to evaluate the efficacy and safety of high-specific-activity I-131 meta-iodobenzylguanidine in patients with advanced pheochromocytoma or paraganglioma through analyzing the complete biomarker response dataset. The study showed significant and long-lasting biomarker responses in patients, which correlated with blood pressure control and objective tumor response rate.
ENDOCRINE-RELATED CANCER
(2023)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)