Article
Toxicology
Kenji Toyota, Tomomi Sato, Taisen Iguchi, Tsuyoshi Ohira
Summary: The freshwater zooplanktonDaphnia magna has been used in ecotoxicology studies for males offspring production. A reliable male- or female-producing system was established using Daphnia pulexWTN6 strain by changing the rearing photoperiod, revealing factors such as ionotropic glutamate receptors and protein kinase C. The study provided an experimental method for in vivo screening of both JH agonists and antagonists and suggested divergent male sex-determining processes betweenD. magnaandD. pulex.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Environmental Sciences
Paolo Cocci, Gilberto Mosconi, Francesco Alessandro Palermo
Summary: Tributyltin (TBT) induces imposex in marine snails through the retinoid X receptor (RXR)-dependent pathway, with potential effects on processes such as differentiation, apoptosis, and embryonic development. This study investigated the RXR expression changes in Tritia mutabilis embryos exposed to different TBT concentrations, showing time-dependent alterations in gene transcription and DNA methylation levels. Overall, these findings suggest that RXR plays a crucial role in early T. mutabilis embryo development and may mediate epigenetic changes induced by TBT exposure.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cell Biology
Yannick Dauwe, Lucile Mary, Fabiana Oliviero, Marina Grimaldi, Patrick Balaguer, Veronique Gayrard, Laila Mselli-Lakhal
Summary: The nuclear receptor CAR, in partnership with RXR, regulates hepatic genes involved in detoxication and energy metabolism. Activation of CAR can lead to metabolic disorders, including non-alcoholic fatty liver disease, by promoting liver lipogenesis. In this study, synergistic activations of CAR/RXR heterodimer were observed in mice when exposed to certain pesticides, resulting in steatosis and metabolic disruption characterized by increased cholesterol and decreased free fatty acid levels.
Article
Biochemistry & Molecular Biology
Fuqiang Ge, Qiaoling Yu, Jun Zhang, Yaoyao Han, Dongfa Zhu, Xi Xie
Summary: The E93 gene was identified and found to be widely distributed in adult tissues of the swimming crab. The expression levels of PtE93 mRNA in Y-organ and epidermis fluctuated during the molt cycle, suggesting its involvement in juvenile molting. Treatment with 20E induced PtE93 expression, while treatment with MF showed the opposite effect. The study also observed a negative correlation between PtE93 and ecdysteroid biosynthesis genes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xilei Li, Tiantian Chen, Yang Han, Mengting Huang, Hucheng Jiang, Jiawei Huang, Minhui Tao, Ruihan Xu, Qiming Xie, Shiping Su
Summary: The study identified the Met gene in the Chinese mitten crab as a potential receptor for MF, involved in regulating vitellogenesis. The expression of EsMet and EsVg in the hepatopancreas varied significantly during different developmental stages, with a corresponding change in MF concentration.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xilei Li, Tiantian Chen, Ruihan Xu, Mengting Huang, Jiawei Huang, Qiming Xie, Fan Liu, Shiping Su, Keyi Ma
Summary: MF is a crucial substance in regulating physiological processes in crustaceans, and understanding its synthetic and degradation pathways is important for maintaining appropriate levels of MF. This study identified Es-CXE5 as potentially responsible for degrading MF in the hepatopancreas of Chinese mitten crab, potentially impacting ovarian development.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Environmental Sciences
Mengting Li, Vera Slaveykova
Summary: This study investigated the influence of titanium dioxide nanoparticles (nTiO(2)) on the accumulation and transfer of inorganic and monomethyl mercury in invertebrate Daphnia magna. The results showed that nTiO(2) led to a decrease in total mercury body burden in D. magna exposed through waterborne exposure, but an increase when exposed through nTiO(2) pre-treated with mercury. The presence of nTiO(2) also decreased the total mercury in D. magna when exposed through algal food. Additionally, high concentrations of nTiO(2) favored trophic transfer of mercury through feeding on nTiO(2) pre-treated with mercury. The results provide insights into the role of nTiO(2) in the bioavailability and trophic transfer of mercury in the aquatic environment.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Ming Zhao, Fengying Zhang, Wei Wang, Zhiqiang Liu, Chunyan Ma, Yin Fu, Wei Chen, Lingbo Ma
Summary: The study identified the complete MF biosynthesis pathway in Scylla paramamosain and found that most genes involved in or related to MF synthesis were highly expressed in the mandibular organ, suggesting a crucial regulatory role for the methionine cycle pathway genes during MF synthesis. The phylogenetic and tissue distribution analysis also revealed a possible regulatory discrepancy in the methionine cycle between crustaceans and insects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Roelof A. Wester, Lisa van Voorthuijsen, Hannah K. Neikes, Jelmer J. Dijkstra, Lieke A. Lamers, Siebren Frolich, Maarten van der Sande, Colin Logie, Rik G. H. Lindeboom, Michiel Vermeulen
Summary: Retinoic acid (RA) signaling pathway plays a crucial role in regulating cellular proliferation and differentiation, with perturbations in this pathway implicated in cancer initiation and progression, particularly in the intestine. The activation of Retinoic Acid Receptor and Retinoid X Receptor enhances the transcription of enterocyte-specific genes, while its inhibition results in reduced expression of genes associated with the absorptive lineage, a conserved effect in a human organoid model for colorectal cancer (CRC) progression. Moreover, decreased expression of RXR target genes correlates with poorer CRC prognosis, suggesting RA signaling as a potential therapeutic target in CRC.
Article
Environmental Sciences
Sevgi Basalan Over, Celal Guven, Eylem Taskin, Arif Cakmak, Petek Piner Benli, Yusuf Sevgiler
Summary: The study found that ammonia and TBM induced acute and chronic toxicity effects on D. magna, leading to an energy crisis in the organism. Traditional biomarkers like GST and ChE were not sensitive in detecting these effects, while AMPK and MMP show promise as biomarkers for these toxicants.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xilei Li, Tiantian Chen, Hucheng Jiang, Jiawei Huang, Mengting Huang, Ruihan Xu, Qiming Xie, Haojie Zhu, Shiping Su
Summary: The study explored the role of Es-Kr-h1 gene in crustacean development, suggesting its involvement in ovarian maturation and the JH/MF signaling pathway in E. sinensis. The results also indicated potential conservation of these pathways in crustaceans.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Qing Xu, Yong Wang, Yanan Zhang, Jiangjiang Zhu, Yaqiu Lin
Summary: RXRα promotes the differentiation of intramuscular preadipocytes in goats through targeting KLF8, but it could be replaced by RXRγ.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake
Summary: Tributyltin (TBT), an environmental pollutant, has been found to be toxic to mammals. This study investigated the mechanism by which TBT inhibits autophagic degradation in SH-SY5Y cells. The results showed that TBT reduced the acidity of lysosomes without affecting lysosomal membrane integrity, leading to the impairment of autophagy. This finding suggests that autophagy impairment may be involved in TBT-induced neuronal death and T-cell-dependent thymus atrophy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Junjie Jiang, Jiao Yuan, Zhongyi Hu, Mu Xu, Youyou Zhang, Meixiao Long, Yi Fan, Kathleen T. Montone, Janos L. Tanyi, Omid Tavana, Ho Man Chan, Lin Zhang, Xiaowen Hu
Summary: Computational analysis of nuclear receptors across multiple cancer types reveals their specific expression downregulation and genomic alterations, including mutations and transcript fusions, in certain cancers. Several nuclear receptors are identified as essential genes for cancer cell growth. This comprehensive characterization facilitates the identification and prioritization of biomarkers and therapeutic targets.
Article
Biochemistry & Molecular Biology
Lyndsey A. A. Reich, Ana S. S. Leal, Edmund Ellsworth, Karen T. T. Liby
Summary: RXR agonists have shown efficacy in cancer models, but their downstream effects on gene expression vary. In this study, the effects of the novel RXR agonist MSU-42011 and the FDA approved agonist bexarotene on gene expression in HER2+ mammary tumors were analyzed. Both agonists regulated cancer-related gene categories, but the specific pathways affected differed. Understanding these differential effects can contribute to the development of targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)