期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 286, 期 1-2, 页码 58-62出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2007.10.005
关键词
somatostatin receptors; receptor internalization; endosomal sorting; receptor recycling
The somatostatin receptor subtypes 1-5 (sst(1)-sst(5)) exhibit different intracellular trafficking and endosomal sorting after agonist exposure. The internalization of the somatostatin receptor subtypes sst(2), sst(3) and sst(5) occurs to a much higher extent after somatostatin exposure than of sst(1) or sst(4). After endocytosis, sst(2) and sst(5) recycle to the plasma membrane, whereas sst(3) is predominantly down-regulated. This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst(2), sst(3) and sst(5), and discusses our current knowledge on somatostatin receptor interacting proteins. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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