Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Review
Food Science & Technology
Jocelyn C. Ayala-Fuentes, Rocio Alejandra Chavez-Santoscoy
Summary: Nanotechnology has had a significant impact on the food industry, particularly in the development of healthier and safer functional foods enriched with compounds like flavonoids. However, flavonoids face challenges such as low stability, sensitivity to light, poor water solubility, and limited bioavailability. Nanoencapsulation emerges as a promising strategy to address these challenges and enhance the delivery of flavonoids to different parts of the body.
Review
Food Science & Technology
Abid Naeem, Yang Ming, Hu Pengyi, Kang Yong Jie, Liu Yali, Haiyan Zhang, Xiao Shuai, Wenjing Li, Wu Ling, Zhang Ming Xia, Liu Shan Shan, Zheng Qin
Summary: Despite advances in synthetic chemistry, nature remains the primary source of drug discovery. Flavonoids have shown significant therapeutic activities, yet they face absorption disorders leading to low bioavailability. Further investigation is needed to understand these interactions and enhance their effectiveness in clinical applications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell & Tissue Engineering
Yangge Du, Yunsong Liu, Yongsheng Zhou, Ping Zhang
Summary: In this study, the researchers found that knockdown of CDC20 promoted adipogenic differentiation of bone marrow mesenchymal stromal/stem cells (BMSCs), indicating a potential link between adipogenesis and bone loss disorders such as osteoporosis. The results suggest that CDC20 may be a therapeutic target for fatty bone and osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Food Science & Technology
Sneh Punia Bangar, Vandana Chaudhary, Nitya Sharma, Vasudha Bansal, Fatih Ozogul, Jose M. Lorenzo
Summary: This review provides a comprehensive collation of important information on the biosynthesis, mechanism of action, bioactivities, bioavailability, and toxicological potential of kaempferol. It highlights the antioxidant, antimicrobial, anticancer, neuroprotective, and hepatoprotective activity of kaempferol, while also mentioning the limitations of its poor water solubility and low bioavailability. The review suggests the utilization of advanced delivery systems to improve the stability and efficacy of kaempferol.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Lei Chen, Hui Cao, Qun Huang, Jianbo Xiao, Hui Teng
Summary: Flavonoids, widely distributed in various plants and foods, have shown potential in preventing and treating various diseases. Research is focused on their absorption, metabolism, and application, with emphasis on the importance of nanoparticle delivery systems in enhancing their bioavailability.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Agriculture, Multidisciplinary
Ke Zhao, Mei Yao, Xin Zhang, Feng Xu, Xingfeng Shao, Yingying Wei, Hongfei Wang
Summary: Flavonoids have beneficial biological activities for human health, mainly exerted in the intestine due to low bioavailability. They can modulate the structure of intestinal microorganisms to improve health, and the changes in gut microbes are associated with the development of depression, which can be significantly improved through the gut-brain axis. Therefore, the interaction between flavonoids and intestinal microbes in alleviating depression is discussed.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Nutrition & Dietetics
Antonio Casado-Diaz, Angel Rodriguez-Ramos, Barbara Torrecillas-Baena, Gabriel Dorado, Jose Manuel Quesada-Gomez, Maria Angeles Galvez-Moreno
Summary: Study found that phloretin can inhibit human adipogenesis by increasing beta-catenin and inducing apoptosis in adipocytes during late differentiation. This suggests the potential of phloretin-rich foods for clinical use and regenerative-medicine applications to combat obesity and prevent bone-marrow adiposity.
Article
Cell Biology
Maria Elisa Perico, Tommaso Maluta, Giamaica Conti, Antonio Vella, Lisa Provezza, Tiziana Cestari, Giulia De Cao, Lydia Segalla, Cristina Tecchio, Fabio Benedetti, Francesco Santini, Vincenzo Bronte, Bruno Magnan, Andrea Sbarbati, Dunia Ramarli
Summary: One mechanism of aging in different organs is the accumulation of fat. Our study found that mesenchymal cells are replaced or transdifferentiated by other cells of the same embryological origin during aging. We also observed the presence of new adipocytes in the trabecular matrix of elderly people's bones. In elderly individuals, there exists a relationship between immature myeloid-derived suppressor cells and mesenchymal stem cells, which leads to immunosuppression and increased inflammatory pathways.
Article
Agriculture, Multidisciplinary
Yanping Lin, David Julian McClements, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: The effects of different carrier oil types on the bioavailability and bioactivity of flavonoids were investigated. The results showed that the inclusion of excipient emulsions increased the bioavailability and antioxidant activity of flavonoids. The in vitro bioaccessibility of flavonoids varied depending on the carrier oil, with LCTs having the highest bioaccessibility. However, in vivo pharmacokinetic experiments showed no significant difference in flavonoid concentrations in rat serum among the different carrier oils. These findings provide insights for formulating excipient emulsions to improve the efficacy of flavonoids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sonia Lopez-Letayf, Ina Arie, Shareef Araidy, Imad Abu El-Naaj, Sandu Pitaru, Higinio Arzate
Summary: The study investigated the regenerative capacity of bony primordial constructs derived from human oral mucosa stem cells (hOMSC) and absorbable gelatin in critical size calvaria defects in rats. The results showed that these constructs almost completely regenerated the defects by differentiating into functional osteoblasts, demonstrating their potential for long-term graft integration in bone regeneration.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Review
Polymer Science
Subhajit Maity, Arghya Acharyya, Abhay Sankar Chakraborti
Summary: Flavonoids, plant metabolites with antioxidant properties, have therapeutic potential for cancer and diabetes. However, their medicinal properties are hindered by rapid metabolism, poor absorption, and low solubility. Nanocarriers can improve the bioavailability of flavonoids. Studies suggest that flavonoid-nanoparticle formulations have better therapeutic potential for the treatment of diseases like cancer and diabetes.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Biomedical
Justine Tanjaya, Pin Ha, Yulong Zhang, Chenchao Wang, Yash Shah, Emily Berthiaume, Hsin Chuan Pan, Jiayu Shi, Jinny Kwak, Benjamin Wu, Kang Ting, Xinli Zhang, Chia Soo
Summary: Recent investigations have shown that suppressing PPAR gamma-mediated adipogenesis can improve bone formation in osteoporosis. This study explores a co-treatment strategy using NELL-1 and PPAR gamma suppression, which significantly enhanced bone formation and increased cell proliferation while decreasing apoptosis in mice. This suggests that combining PPAR gamma suppression with NELL-1 therapy may be a promising method to reverse bone loss in osteoporosis.
Article
Multidisciplinary Sciences
Axelle Septembre-Malaterre, Yosra Bedoui, Claude Giry, Philippe Gasque, Pascale Guiraud, Jimmy Selambarom
Summary: O'nyong-nyong virus, closely related to chikungunya virus, causes arthralgia, rash and fever; phenolics and curcuminoids from turmeric have been shown to reduce viral RNA levels and inflammatory status induced by the virus in primary human synovial fibroblasts cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Sierra H. Root, Ivana Vrhovac Madunic, Mark S. Kronenberg, Ye Cao, Sanja Novak, Ivo Kalajzic
Summary: Regulator of G protein signaling 5 (RGS5) acts as a GTPase activator for heterotrimeric G-protein alpha-subunits and is a marker of pericytes. A transgenic mouse model (Rgs5-CreER) was generated for lineage tracing which showed the presence of Rgs5+ cells within endothelial, hematopoietic, and mesenchymal/perivascular cells. Rgs5+ cells expressed osterix and osteocalcin, contributing to new bone formation primarily within the BM niche.
Article
Biochemistry & Molecular Biology
Parvez Khan, Jawed Akhtar Siddiqui, Prakash G. G. Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana Kumari Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. A. Talmon, Prakash Kulkarni, Apar K. K. Ganti, Maneesh Jain, Ravi Salgia, Surinder Kumar Batra, Mohd Wasim Nasser
Summary: Small cell lung cancer (SCLC) is an aggressive subtype of lung cancer with limited therapeutic options. This study aimed to identify and investigate the role of microRNA-1 (miR-1) in SCLC growth and metastasis. It was found that miR-1 is downregulated in SCLC tumor tissues and serum samples, and its overexpression leads to decreased cell growth and metastasis. The study also revealed that miR-1 targets the CXCR4/FOXM1/RRM2 axis, which regulates SCLC growth and metastasis. These findings highlight the potential of miR-1 as a therapeutic target for SCLC.
Article
Biochemistry & Molecular Biology
Rakesh Bhatia, Jawed Akhtar Siddiqui, Koelina Ganguly, Christopher M. Thompson, Andrew Cannon, Abhijit Aithal, Naveenkumar Perumal, Shailendra K. Maurya, Xiaoqi Li, Jesse L. Cox, Channabasavaiah B. Gurumurthy, Satyanarayana Rachagani, Maneesh Jain, Mohd Wasim Nasser, Surinder K. Batra, Sushil Kumar
Summary: Mucin4 (MUC4) expression coincides with EGFR expression in early PanIN1 lesions, and sustained EGFR signaling in PanIN lesions is dependent on MUC4. Depletion of MUC4 delays PanIN lesion formation and reduces EGFR phosphorylation, suggesting impaired oncogenic signaling. MUC4 interacts with EGFR and prevents its degradation, leading to sustained downstream signaling. Targeting the MUC4-EGFR interaction may enhance the efficacy of EGFR-targeted therapies in PDAC.
Article
Chemistry, Multidisciplinary
Vianni Chopra, Jijo Thomas, Swati Kaushik, Swati Rajput, Rajdeep Guha, Bidya Mondal, Sudip Naskar, Dipankar Mandal, Gaurav Chauhan, Naibedya Chattopadhyay, Deepa Ghosh
Summary: The development of new injectable bone cements with appropriate properties has gained interest in the field of nanoscience. Injectable bone cements made with calcium sulfate (CS) are compatible and self-setting, but have limitations in terms of resorption, bioactivity, and mechanical strength. This study presents a modified CS-based injectable bone cement (CSmod) reinforced with a conductive nanocomposite and functionalized with vancomycin. The cement exhibits favorable injectability, setting times, and improved mechanical properties, as well as antimicrobial and osteoinductive properties. The ability of CSmod to recruit endothelial cells and enhance bone regeneration is demonstrated in rat models.
Review
Endocrinology & Metabolism
Swati Rajput, Aditya Dutta, Singh Rajender, Ambrish Mithal, Naibedya Chattopadhyay
Summary: In this meta-analysis, the effectiveness of anti-resorptive therapies (bisphosphonates and denosumab) in preventing/treating bone loss and hypercalcemia in patients with primary hyperparathyroidism (PHPT) was investigated. The results showed that anti-resorptives significantly increased bone mineral density (BMD) at the lumbar spine and femoral neck, increased serum parathyroid hormone (PTH), and decreased serum calcium levels. Bisphosphonates only increased BMD at the lumbar spine, while denosumab increased BMD at both the lumbar spine and femur neck. Alendronate significantly improved bone loss and hypercalcemia in PHPT patients, without altering PTH and calcium levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Oncology
Gunjan Sharma, Jessica Dal Col, Jawed Akhtar Siddiqui
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiayan Huang, Ezgi Caliskan Guzelce, Shadi K. Gholami, Kara L. Gawelek, Richard N. Mitchell, Luminita H. Pojoga, Jose R. Romero, Gordon H. Williams, Gail K. Adler
Summary: This study found that renal KIM-1 levels increase in a cardiorenal injury model induced by L-NAME/ANG II, and the impact of mineralocorticoid receptor activation and blockade on KIM-1 is uncertain. Additionally, the use of statins is associated with lower aldosterone levels, and both eplerenone and simvastatin can prevent the increase in renal KIM-1, while pravastatin does not affect these damage markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yaritza Inostroza-Nieves, Alicia Rivera, Jose R. Romero
Summary: A study found that Major Histocompatibility Complex (MHC) molecules play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules after exposure to cytokines. SCD is characterized by vascular endothelial cell activation, oxidative stress, sickle cell adhesion, and excess levels of endothelin-1 (ET-1). The study suggests that ET-1 is a novel regulator of MHC class II molecules and ET-1 receptor blockade may be a promising therapeutic approach for regulating immune and vascular responses in SCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Chirag Kulkarni, Shivani Sharma, Konica Porwal, Swati Rajput, Sreyanko Sadhukhan, Vaishnavi Singh, Akanksha Singh, Sanjana Baranwal, Saroj Kumar, Aboli Girme, Alka Raj Pandey, Suriya Pratap Singh, Koneni V. Sashidhara, Navin Kumar, Lal Hingorani, Naibedya Chattopadhyay
Summary: A study found that Coleus forskohlii root extract (CF) containing forskolin can activate adenylate cyclase (AC) and increase intracellular cyclic adenosine monophosphate (cAMP) levels in osteoblasts, protecting obese individuals against weight gain. Through a series of experiments and tests, researchers found that CFE can promote the maintenance of bone mass, bone strength, and bone material.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Tusar Kanta Acharya, Subhashis Pal, Arijit Ghosh, Shamit Kumar, Satish Kumar, Naibedya Chattopadhyay, Chandan Goswami
Summary: Research has found that TRPV4, a mechanosensitive ion channel, is naturally present in osteoblast cells and is involved in regulating calcium levels, gene expression, and bio-mineralization. Activation of TRPV4 also affects mitochondrial calcium levels and metabolism. Different mutations of TRPV4 have varying effects on mitochondrial morphology and translocation, suggesting that TRPV4-related bone disorders and channelopathies are often caused by mitochondrial abnormalities. These findings have significant biomedical implications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jijo Thomas, Vianni Chopra, Swati Rajput, Rajdeep Guha, Naibedya Chattopadhyay, Deepa Ghosh
Summary: Injectable hydrogels have been used for cartilage repair, but some of them have issues with rapid degradation and low mechanical strength. To address these challenges, a bioinspired double network hydrogel (BDNH) was developed, which exhibits temperature-dependent stiffening after implantation. The BDNH showed excellent cell viability, long time cell proliferation, and cartilage specific matrix production, making it a potential candidate for cartilage tissue engineering.
Article
Chemistry, Multidisciplinary
Himadri Shekar Roy, K. M. Neethu, Swati Rajput, Sreyanko Sadhukhan, Vijayendran Gowri, Arif Hassan Dar, Malika Monga, Navita Salaria, Rajdeep Guha, Naibedya Chattopadhyay, Govindasamy Jayamurugan, Deepa Ghosh
Summary: The excess nitric oxide (NO) produced in response to bacterial/proinflammatory stimuli is responsible for pathological conditions. Current approaches targeting excess NO production have been unsuccessful. Urea-functionalized push-pull chromophores with NO scavenging properties have shown therapeutic efficacy in modulating NO-mediated diseases and have potential for further research.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Medicine, Research & Experimental
Kaveri R. Washimkar, Manendra Singh Tomar, Chirag Kulkarni, Shobhit Verma, Ashutosh Shrivastava, Naibedya Chattopadhyay, Madhav Nilakanth Mugale
Summary: This study elucidates the association of TGF-β1/Smad and Nrf2 signaling in the EMT and metabolic alterations associated with the etiology and progression of PF.
Article
Endocrinology & Metabolism
Konica Porwal, Shivani Sharma, Saroj Kumar, Manendra Singh Tomar, Sreyanko Sadhukhan, Swati Rajput, Chirag Kulkarni, Ashutosh Shrivastava, Navin Kumar, Naibedya Chattopadhyay
Summary: We investigated the effects of hormonal and non-hormonal oral contraceptives on bone mass, mineralization, composition, mechanical properties, and metabolites in pubertal female rats. Both types of contraceptives had adverse effects on various skeletal parameters, with the hormonal contraceptive having a greater negative impact on bone strength. Overall, the study highlights the importance of considering the effects of oral contraceptives on bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alicia Rivera, Christopher Vega, Arelys Ramos-Rivera, Enrique R. Maldonado, Gregory N. Prado, Hope E. Karnes, Yuri A. Fesko, L. Michael Snyder, Seth L. Alper, Jose R. Romero
Summary: The activation of MR plays an important role in SCD by modulating ET-1 levels, improving hematological parameters, and reducing inflammation. The findings suggest that MR blockade could be a potential therapeutic approach for SCD.
Review
Endocrinology & Metabolism
Sreyanko Sadhukhan, Shruti Sethi, Singh Rajender, Ambrish Mithal, Naibedya Chattopadhyay
Summary: This meta-analysis study provides the first definition of the pathophysiology of idiopathic osteoporosis (IOP), finding that it primarily leads to a decline in lumbar spine bone density compared to healthy controls, with no changes in bone turnover markers. Further research is needed to understand gender differences and the significance of altered hormone levels in this condition.
Article
Cell Biology
Karina A. Pena, Sofya Savransky, Breanna Lewis
Summary: Compartmentalization of GPCR signaling is an emerging topic that emphasizes the importance of spatial bias in signaling for physiological relevance. PTH1R was the first GPCR discovered to signal via cAMP from endosomes, challenging the conventional model of GPCR signaling. The location of cAMP generation determines the physiological outcomes of GPCR signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Cheng-Xu Ma, Xiao-Ni Ma, Jin-Jin Liu, Cong-Hui Guan, Ying-Dong Li, Nan Zhao, Didac Mauricio, Song-Bo Fu
Summary: The downregulation of primary cilia (PCs) due to BRAFV600E mutation contributes to the aggressiveness and lymph node metastasis of Papillary Thyroid Cancer (PTC).
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Kejun Wu, Cuihua Huang, Wenrong Zheng, Yubin Wu, Qintao Huang, Menghua Lin, Ruonan Gao, Liqin Qi, Guanlian He, Xiaoying Liu, Xiaohong Liu, Linxi Wang, Zhou Chen, Libin Liu
Summary: Recurrent non-severe hypoglycemia in patients with diabetes is associated with cognitive impairment. This study found that this condition is associated with reduced mitophagy in the hippocampus, leading to mitochondrial dysfunction and neurological impairment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Yifei Lv, Yizhou Huang, Huiyu Fan, Yunxiu Zhao, Linjuan Ma, Yibing Lan, Chunming Li, Peiqiong Chen, Zheng Lou, Jianhong Zhou
Summary: Before menopause, females have a lower incidence of cardiovascular disease than age-matched males, possibly due to the protective effects of sex hormones. 17 beta-E2 inhibits THBS1 expression, preventing cell senescence and apoptosis, and counteracts oxidative stress by suppressing the TGF-beta/Smad signaling pathway.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Ana C. L. Camargo, Flavia B. Constantino, Sergio A. A. Santos, Ketlin T. Colombelli, Luiz M. F. Portela, Matheus N. Fioretto, Luisa A. Barata, Guilherme T. Valente, Carlos S. Moreno, Luis A. Justulin
Summary: This study examined the effects of maternal malnutrition on the transcriptomic landscape of the ventral prostate in rats. It found that changes in molecular pathways related to cellular development and tissue morphogenesis were associated with maternal malnutrition. The Abcg1 gene was found to be deregulated in both malnourished rats and prostate cancer models and patients.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Sandra Romero-Cordoba, Mayel Chirinos, Nancy Noyola-Martinez, Nayeli Torres-Ramirez, Mitzi Garcia-Olivares, Juan Pablo Aragon-Hernandez, Ixchel Ramirez-Camacho, Rosa Zuniga, Fernando Larrea, Ali Halhali, David Barrera
Summary: This study analyzed the effects of calcitriol, TGF-131, and their combination on human trophoblast cells. The results showed that the combination treatment modified the transcriptional landscape and mainly affected the storage, activity, and metabolism of lipids, which may have an impact on placental development.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Traver J. Wright, Richard B. Pyles, Melinda Sheffield-Moore, Rachel R. Deer, Kathleen M. Randolph, Kristen A. Mcgovern, Christopher P. Danesi, Charles R. Gilkison, Weston W. Ward, Jayson A. Vargas, Peyton A. Armstrong, Sarah E. Lindsay, Mohammed F. Zaidan, Justin Seashore, Tamara L. Wexler, Brent E. Masel, Randall J. Urban
Summary: This study investigates the persistent neurologic symptoms in COVID-19 patients after recovery and explores the association between these symptoms and disrupted growth hormone secretion and gastrointestinal discomfort.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
Article
Cell Biology
Li-Li Chen, Ya-Qin Li, Zhi-Hui Kang, Xuan Zhang, Su-Yan Gu, Na Wang, Xue-Yan Shen
Summary: Defects in trophoblastic EMT caused by dysregulation of circTNRC18's interaction with LIN28A play a vital role in the development of preeclampsia. LIN28A overexpression suppresses circTNRC18-mediated inhibition of trophoblast migration, invasion, and EMT, while LIN28A knockdown promotes them. Furthermore, circTNRC18 regulates the intracellular distribution of LIN28A and the expression of insulin-like growth factor II, affecting cell migration and invasion. Targeting the circTNRC18-LIN28A regulatory axis may provide a novel treatment approach for preeclampsia.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2024)
