WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

Dickkopf-1 expression is down-regulated during the colorectal adenoma-carcinoma sequence and correlates with reduced microvessel density and VEGF expression

(2015) Zhiyong Liu et al.   HISTOPATHOLOGY

β-Catenin Links Hepatic Metabolic Zonation with Lipid Metabolism and Diet-Induced Obesity in Mice

(2014) Jaideep Behari et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt modulates MCL1 to control cell survival in triple negative breast cancer

(2014) Lixin Yang et al.   BMC CANCER

PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells

(2014) Haili Wu et al.   CELLULAR SIGNALLING

Wnt meets Warburg: another piece in the puzzle?

(2014) C. B. Thompson   EMBO JOURNAL

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

Wnt/β-catenin signaling pathway may regulate the expression of angiogenic growth factors in hepatocellular carcinoma

(2014) BO QU et al.   Oncology Letters

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Caveolin-1-LRP6 Signaling Module Stimulates Aerobic Glycolysis in Prostate Cancer

(2013) S. A. Tahir et al.   CANCER RESEARCH

WNT5A-mediated  -catenin-independent signalling is a novel regulator of cancer cell metabolism

(2013) V. Sherwood et al.   CARCINOGENESIS

WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

(2013) Emel Esen et al.   Cell Metabolism

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate Dehydrogenase 5 (SDH5) Regulates Glycogen Synthase Kinase 3β-β-Catenin-mediated Lung Cancer Metastasis

(2013) Jun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Wnt Inhibitors Secreted Frizzled-Related Proteins (SFRPs) in Human Adipose Tissue

(2013) Anna Ehrlund et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Wnt Signaling Pathway in Non-Small Cell Lung Cancer

(2013) D. J. Stewart   JNCI-Journal of the National Cancer Institute

Understanding Metabolic Regulation and Its Influence on Cell Physiology

(2013) Christian M. Metallo et al.   MOLECULAR CELL

AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity

(2013) H. T. Kwan et al.   PLoS One

Mice Deficient in Sfrp1 Exhibit Increased Adiposity, Dysregulated Glucose Metabolism, and Enhanced Macrophage Infiltration

(2013) Kelly J. Gauger et al.   PLoS One

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

(2012) S. Y. Lee et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose Uptake

(2012) Daniel Zeve et al.   Cell Metabolism

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

(2012) Hiroyuki Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer

(2012) Ana Chocarro-Calvo et al.   MOLECULAR CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells

(2012) Renyue Bao et al.   PLoS One

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Importance of β-Catenin in glucose and energy homeostasis

(2012) Lynda Elghazi et al.   Scientific Reports

Planar Cell Polarity and the Developmental Control of Cell Behavior in Vertebrate Embryos

(2011) John B. Wallingford   Annual Review of Cell and Developmental Biology

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Nuclear Factor of Activated T Cells (NFAT) Proteins Repress Canonical Wnt Signaling via Its Interaction with Dishevelled (Dvl) Protein and Participate in Regulating Neural Progenitor Cell Proliferation and Differentiation

(2011) Tao Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Wnt signalling and the control of cellular metabolism

(2010) Jaswinder K. Sethi et al.   BIOCHEMICAL JOURNAL

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

(2010) J. C. Yoon et al.   GENES & DEVELOPMENT

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neurofilament Heavy Polypeptide Regulates the Akt-β-Catenin Pathway in Human Esophageal Squamous Cell Carcinoma

(2010) Myoung Sook Kim et al.   PLoS One

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

(2009) A. J. Chien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome

(2008) P. D. Da Forno et al.   CLINICAL CANCER RESEARCH

From individual Wnt pathways towards a Wnt signalling network

(2008) H. A Kestler et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA