Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis

Gain-of-Function of Stat5 Leads to Excessive Granulopoiesis and Lethal Extravasation of Granulocytes to the Lung

(2013) Wan-chi Lin et al.   PLoS One

Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways

(2012) C.-C. Chen et al.   GENES & DEVELOPMENT

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration

(2012) Daisuke Yamaji et al.   NUCLEIC ACIDS RESEARCH

Conditional activation of Pik3ca H1047R in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations

(2012) W Yuan et al.   ONCOGENE

Generation of a Novel MMTV-tTA Transgenic Mouse Strain for the Targeted Expression of Genes in the Embryonic and Postnatal Mammary Gland

(2012) Kazuhito Sakamoto et al.   PLoS One

Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors

(2011) D. S. Meyer et al.   CANCER RESEARCH

Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death and contributes to tumourigenesis

(2011) M M Caffarel et al.   CELL DEATH AND DIFFERENTIATION

Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones

(2010) Jie Dong et al.   DEVELOPMENTAL BIOLOGY

Stat5 Promotes Survival of Mammary Epithelial Cells through Transcriptional Activation of a Distinct Promoter in Akt1

(2010) B. A. Creamer et al.   MOLECULAR AND CELLULAR BIOLOGY

Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer

(2010) K Sakamoto et al.   ONCOGENE

Allele-specific tumor spectrum in Pten knockin mice

(2010) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammary Epithelial Reconstitution with Gene-Modified Stem Cells Assigns Roles to Stat5 in Luminal Alveolar Cell Fate Decisions, Differentiation, Involution and Mammary Tumor Formation

(2010) Vida Vafaizadeh et al.   STEM CELLS

Mammary Gland Growth Factors: Roles in Normal Development and in Cancer

(2010) N. E. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Targeting Janus Kinase 2 in Her2/neu-Expressing Mammary Cancer: Implications for Cancer Prevention and Therapy

(2009) K. Sakamoto et al.   CANCER RESEARCH

Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A

(2009) D. Yamaji et al.   GENES & DEVELOPMENT

Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging

(2009) Bradley A. Creamer et al.   GENESIS

Distinct roles of the three Akt isoforms in lactogenic differentiation and involution

(2008) Ioanna G. Maroulakou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Dual Role for Oncostatin M Signaling in the Differentiation and Death of Mammary Epithelial Cellsin Vivo

(2008) Paul G. Tiffen et al.   MOLECULAR ENDOCRINOLOGY