Parkin-Dependent Degradation of the F-Box Protein Fbw7  Promotes Neuronal Survival in Response to Oxidative Stress by Stabilizing Mcl-1

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

(2013) Anne Kathrin Müller-Rischart et al.   MOLECULAR CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

(2012) M M Magiera et al.   CELL DEATH AND DIFFERENTIATION

Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease

(2012) Tohru Kitada et al.   Current Treatment Options in Neurology

Fbw7  and Fbw7  Collaborate To Shuttle Cyclin E1 into the Nucleolus for Multiubiquitylation

(2012) N. Bhaskaran et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitophagy and Parkinson's disease: Be eaten to stay healthy

(2012) Rosa L.A. de Vries et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

(2012) Azadeh Arabi et al.   Nature Communications

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction

(2012) Hidefumi Fukushima et al.   Cell Reports

Small Molecule c-jun-N-Terminal Kinase Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson’s Disease

(2011) Jeremy W. Chambers et al.   ACS Chemical Neuroscience

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

(2011) Akinobu Matsumoto et al.   CANCER SCIENCE

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Mitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorder

(2011) Yuzuru Imai et al.   CURRENT OPINION IN NEUROBIOLOGY

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

(2011) Aleksandar Rakovic et al.   PLoS One

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cullin protein family

(2011) Antonio Sarikas et al.   GENOME BIOLOGY

Mitophagy and Parkinson's disease: The PINK1–parkin link

(2010) Emma Deas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

(2010) Yakup Batlevi et al.   NEUROBIOLOGY OF DISEASE

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation

(2009) A. Kathrin Lutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

(2009) Tohru Kitada et al.   JOURNAL OF NEUROCHEMISTRY

Toxic effects of dopamine metabolism in Parkinson's disease

(2009) Nobutaka Hattori et al.   PARKINSONISM & RELATED DISORDERS

The Fbxw7/hCdc4 tumor suppressor in human cancer

(2008) YingMeei Tan et al.   CANCER LETTERS

SCFFbxw7/hCdc4 targets cyclin E2 for ubiquitin-dependent proteolysis

(2008) Kathleen Klotz et al.   EXPERIMENTAL CELL RESEARCH

SCFCdc4 acts antagonistically to the PGC-1  transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

(2008) B. L. Olson et al.   GENES & DEVELOPMENT

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage

(2008) N. Arbour et al.   JOURNAL OF NEUROSCIENCE

mTORC1 promotes survival through translational control of Mcl-1

(2008) J. R. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY