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Medicine, Research & Experimental
Meng-Lu Chen, Chun-Gu Hong, Tao Yue, Hong-Ming Li, Ran Duan, Wen-Bao Hu, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Si-Yuan Tang, Hui Xie, Zheng-Zhao Liu
Summary: The study found biphasic changes of miR-331-3p and miR-9-5p in AD progression, inhibiting these two microRNAs can promote autophagic clearance of A beta and prevent AD development. This was demonstrated in experiments and offers a potential new therapeutic strategy for AD patients.
Article
Medicine, Research & Experimental
Zhuohui Liu, Haoyu Liu, Deshun Yu, Jingyu Gao, Biao Ruan, Ruiqing Long
Summary: In this study, it was found that miR-29b-3p indirectly regulated the expression of integrin beta 1 and alpha-tubulin in CRSwNPs by modulating MMP-9 expression, potentially serving as a novel target for clinical treatment of chronic rhinosinusitis with nasal polyps.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Lin Yang, Hong-Gang Sui, Meng-Meng Wang, Jia-Yin Li, Xiao-Feng He, Jing-Yuan Li, Xiao-Zeng Wang
Summary: Plasma levels of miR-30c-1-3p and MMP-9 may serve as candidate biomarkers for AAA progression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Sonia Kiran, Mousumi Mandal, Ahmed Rakib, Amandeep Bajwa, Udai P. Singh
Summary: This study investigates the role and mechanism of miR-10a-3p in adipose inflammation and adipogenesis using ex vivo and in vitro approaches. The findings suggest that miR-10a-3p mimic reduces the expression of inflammatory cells and cytokines, and induces the expression of FoxP3 in adipose tissue. In vitro experiments also show that miR-10a-3p mimic reduces the expression of inflammatory genes and lipid accumulation. This study provides a new opportunity for the development of miR-10a-3p as a novel therapeutic for adipose inflammation and its associated metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Amit Chandra, Kritika Sharma, Kunal Pratap, Vijaypal Singh, Neeru Saini
Summary: The study demonstrates that inhibition of miR-128-3p can lower serum cholesterol levels, increase the clearance of cholesterol by SR-B1 and LDLR, and promote the catabolism of cholesterol by CYP7A1, highlighting its significant therapeutic implications in reversing hypercholesterolemia.
Article
Biochemistry & Molecular Biology
Pengwei Wang, Senlin Mao, Tingting Yi, Lihua Wang
Summary: In this study, the researchers established a mouse model of VaD and found that the expression levels of MALAT1, miR-9-3p, and SAP97 were altered in the hippocampus of VaD mice. They also discovered the binding relationship between MALAT1 and miR-9-3p, as well as the negative regulatory role of miR-9-3p on SAP97. These findings contribute to our understanding of the molecular mechanisms underlying VaD.
BIOCHEMICAL GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Panyu Yang, Yanyan Yang, Xiangqin He, Pin Sun, Ying Zhang, Xiaoxia Song, Yu Tian, Tingyu Zong, Jianmin Ma, Xiaofei Chen, Qifeng Lv, Tao Yu, Zhirong Jiang
Summary: This study revealed that miR-153-3p regulates cardiomyocyte apoptosis by directly targeting beta II spectrin, particularly by regulating the expression of caspase 7. Targeting the miR-153-3p/beta II spectrin pathway effectively regulated FA-induced damage during heart development in an animal model. The findings suggest that miR-153-3p may serve as a potential target for the clinical diagnosis and treatment of CHD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Rhafaela Lima Causin, Andre Van Helvoort Lengert, Izabela Natalia Faria Gomes, Ana Julia Aguiar De Freitas, Marcela Nunes Rosa, Ricardo Dos Reis, Rui Manuel Reis, Marcia Maria Chiquitelli Marques
Summary: miR-130a-3p is overexpressed in cervical cancer cells and plays a significant role in the development of cervical cancer. Inhibiting miR-130a-3p can significantly reduce the proliferation, migration, and invasion of cervical cancer cells. miR-130a-3p may regulate the biological functions of cervical cancer cells by directly targeting the DLL1 gene. Therefore, miR-130a-3p may serve as a biomarker for determining cervical cancer progression.
Article
Endocrinology & Metabolism
Keyan Hu, Xueying Liu, Hongfeng Chang, Yi Zhang, Hui Zhou, Lei Liu, Xin Zhang, Ziying Jiao, Bing Shen, Qiu Zhang
Summary: The study found that miR-221-3p can promote wound healing in diabetes by targeting THBS1. Lack of miR-221-3p may result in impaired healing in chronic wounds of type 2 diabetes.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkanen
Summary: The study identified plasma miR-9-3p and miR-136-3p as promising biomarker candidates for mTBI, showing potential for distinguishing mTBI patients with high sensitivity and specificity. Further validation in a larger patient population is needed to confirm their diagnostic utility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yanhong Liu, Yan Ding, Yapeng Hou, Tong Yu, Hongguang Nie, Yong Cui
Summary: The study demonstrated that MSCs reversed the overexpression of fibrosis markers and TGF-beta 1/Smad signaling pathway proteins and mRNAs after TGF-beta 1 treatment and increased the level of miR-130a-3p. The miR-130a-3p/TGF-beta RII axis could suppress the differentiation of lung fibroblasts via the TGF-beta 1/Smad signaling pathway, thereby reducing the process of PF.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keiko Mizuno, Kengo Tanigawa, Shunsuke Misono, Takayuki Suetsugu, Hiroki Sanada, Akifumi Uchida, Minami Kawano, Kentaro Machida, Shunichi Asai, Shogo Moriya, Hiromasa Inoue, Naohiko Seki
Summary: Studies have shown that both strands of certain miRNAs derived from miRNA duplexes are involved in cancer pathogenesis, with miR-150-3p acting as a tumor-suppressive miRNA in lung squamous cell carcinoma by targeting cell cycle-related genes. Direct control of HELLS expression by miR-150-3p promotes the malignant phenotype of LUSQ cells.
Article
Oncology
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki
Summary: Accumulating evidence indicates that the miR-30 family plays a critical role in various human cancers, acting as either tumor suppressors or oncogenes. The downregulation of miR-30c-1-3p and miR-30c-2-3p in cancer tissues is associated with worse prognosis in breast cancer (BrCa) patients, and overexpression of these miRNAs inhibits cancer cell aggressiveness, suggesting their tumor-suppressor function in BrCa cells. Furthermore, TRIP13 is identified as a direct target of these two miRNAs and its inactivation attenuates BrCa cell aggressiveness and prevents malignant transformation. Understanding the molecular networks controlled by miRNAs, including passenger strands, may lead to the identification of diagnostic markers and therapeutic targets for BrCa.
Article
Biochemistry & Molecular Biology
Fang Liu, Lu-jing Jiang, Yue-xin Zhang, Si-ting Xu, Si-ling Liu, Jian-tao Ye, Pei-qing Liu
Summary: Myocardial infarction (MI) increases the risk of heart failure and sudden death, but effective treatments are still lacking in clinical practice. Abnormal expression of microRNAs (miRNAs) has been found to play a crucial role in cardiovascular diseases. This study investigated the involvement of miRNA-214-3p in MI. The results showed that miR-214-3p was significantly upregulated in the infarcted region in mouse hearts and in hypoxia-exposed rat cardiomyocytes, which was accompanied by increased ferroptosis. Inhibition of miR-214-3p improved cardiac function, reduced infarct size, and attenuated iron accumulation and oxidant stress. MiR-214-3p could promote ferroptosis and cellular impairments, while its inhibition protected cells from hypoxic injury. Furthermore, malic enzyme 2 (ME2) was identified as a direct target of miR-214-3p. Overexpression of ME2 ameliorated the detrimental effects induced by miR-214-3p mimic, while its depletion compromised the protective role of miR-214-3p inhibitor. These findings suggest that miR-214-3p contributes to enhanced ferroptosis during MI by suppressing ME2. Inhibition of miR-214-3p may represent a novel approach for treating MI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Huiqing Hou, Yafei Wang, Lan Yang, Yongjun Wang
Summary: This study demonstrates that fibrinogen deposition inhibits remyelination after ischemic stroke by activating ACVR1 and suppressing OPC differentiation. It also reveals that NSC-derived exosomal miR-128-3p promotes OPC differentiation into OLs by inhibiting BMP signaling. These findings suggest that NSC-derived exosomal miR-128-3p may serve as a potential therapeutic target for ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)