Review
Cell Biology
Bingyi Zhou, Deliang Liu, Yuyong Tan
Summary: Cancer is the second leading cause of death worldwide, with digestive system cancers being a primary contributor. Acetylation and deacetylation play crucial roles in cancer development, with HDAC6 being a widely studied enzyme that is upregulated in various tumors and associated with clinicopathological characteristics. There is ongoing research on HDAC6 inhibitors and their potential in inhibiting tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhongwei Li, Chaozhen Chen, Hongmei Yong, Lei Jiang, Pengfei Wang, Sen Meng, Sufang Chu, Zhen Li, Qingxiang Guo, Junnian Zheng, Jin Bai, Hailong Li
Summary: PRMT2 is upregulated in renal cell cancer and promotes cell proliferation and motility by enhancing Wnt signaling through the H3R8me2a-mediated transcriptional activation of WNT5A. High expression of PRMT2 and WNT5A is associated with poor clinicopathological characteristics and overall survival in RCC patients, suggesting their potential as predictive diagnostic biomarkers for RCC metastasis.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Risaku Hirai, Shumin Wang, Taku Demura, Misato Ohtani
Summary: This study identifies histone deacetylase (HDAC) inhibitors as regulators of xylem vessel cell differentiation, affecting gene expression and the formation of the negative regulator complex OFP1/4-MYB75-KNAT7-BLH6. The findings suggest that active regulation of histone deacetylation by HDACs plays a role in xylem vessel cell differentiation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Han Wu, Xiaofan Yin, Xibao Zhao, Zherui Wu, Yue Xiao, Qianqian Di, Ping Sun, Haimei Tang, Jiazheng Quan, Weilin Chen
Summary: HDAC11 negatively controls antifungal immunity and its deficiency enhances fungal killing. HDAC11 inhibitor also exhibits antifungal therapeutic effects.
Article
Cell Biology
Tinghui Shao, Yujia Xue, Mingming Fang
Summary: The study investigated the transcriptional regulation mechanism of Clca2 in cardiac fibrosis, revealing that the Twist1-HDAC1 complex can suppress the expression of Clca2 in cardiac fibroblasts, potentially leading to FMyT and cardiac fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel Finke, Leonard M. Schanze, Friederike Schreiter, Michael M. Kreusser, Hugo A. Katus, Johannes Backs, Lorenz H. Lehmann
Summary: Loss of HDAC4 in cardiomyocytes leads to a global epigenetic shift from a 'repressive' to an 'active' status, characterized by increased levels of H3K4me3, H3K9ac, and H3K27ac, and decreased levels of H3K9me2 and H3K27me3. This epigenetic change is associated with overrepresentation of MEF2 binding sites in upregulated promoter regions of H3K9ac and H3K4me3, suggesting a role for HDAC4 in regulating gene expression in response to stimuli such as exercise.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jie Wang, Feng Yun, Jiahui Sui, Wenpeng Liang, Dingding Shen, Qi Zhang
Summary: Epilepsy, a common and severe chronic neurological disorder, has been the subject of extensive research on post-translational modification (PTM) mechanisms, particularly protein acetylation modifications. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation, with HATs transferring acetyl groups to lysine residues and HDACs removing acetyl groups. Epilepsy is associated with the regulation of gene expression through histone acetylation and deacetylation, as well as the acetylation modification of non-histone substrates. HDAC inhibitors (HDACi) have been developed as potential antiepileptic drugs. This review summarizes the changes in acetylation modification during epileptogenesis, the application of HDACi in epilepsy treatment, and the underlying mechanisms. Further understanding of acetylation regulation will provide insights into the pathological mechanism of epilepsy and novel therapeutic ideas.
Article
Food Science & Technology
Hee Yang, Gihyun Hur, Tae Kyung Lee, Jong-Eun Kim, Jong Hun Kim, Jong Rhan Kim, Jiyoung Kim, Jung Han Yoon Park, Ki Won Lee
Summary: This study found that sulforaphane (SFN), a natural HDAC inhibitor, can prevent obesity-related metabolic dysregulation by enhancing mitochondrial biogenesis and function via targeting the HDAC8-PGC alpha axis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell Biology
Huihua Kai, Qiyong Wu, Ruohan Yin, Xiaoqiang Tang, Haifeng Shi, Tao Wang, Ming Zhang, Changjie Pan
Summary: This study investigated the impact of lncRNA NORAD on vascular endothelial cell injury and atherosclerosis in CAD. The results showed that increased expression of lncRNA NORAD was associated with vascular endothelial cell injury and atherosclerosis development, while knockdown of lncRNA NORAD alleviated these effects both in vitro and in vivo. Additionally, it was found that lncRNA NORAD suppresses VEGF gene transcription through H3K9 deacetylation and recruitment of HDAC6, contributing to vascular endothelial cell injury and atherosclerosis development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Min Tang, Isabel Regadas, Sergey Belikov, Olga Shilkova, Lei Xu, Erik Wernersson, Xuewen Liu, Hongmei Wu, Magda Bienko, Mattias Mannervik
Summary: In this study, the crucial functions of HDAC3 in embryo development were investigated in Drosophila. The findings demonstrate that HDAC3 is involved in both gene activation and repression, and that lysine substitution in the N terminus disrupts its catalytic activity and activator function, while a combination of substitutions enhances its repressor activity.
Article
Biochemistry & Molecular Biology
Shicong Zhu, Cheng Xing, Guangsen Zhang, Hongling Peng, Zhihua Wang
Summary: In this study, CC1007 was found to inhibit the proliferation of multiple myeloma cells and induce apoptosis and cell cycle arrest. Additionally, CC1007 decreased the expression of MEF2C and HDAC7, disrupting their interaction and promoting the overexpression of Nur77. These findings suggest that CC1007 may be a promising drug for the treatment of multiple myeloma.
BIOORGANIC CHEMISTRY
(2022)
Article
Microbiology
Zhongling Wu, Huanbin Shi, Yuan Li, Fei Yan, Ziyue Sun, Chuyu Lin, Mengting Xu, Fucheng Lin, Yanjun Kou, Zeng Tao
Summary: Autophagy is a conserved degradation and recycling pathway in eukaryotes that is important for normal growth and development. The transcriptional regulation of autophagy-related genes (ATGs) is crucial for maintaining the appropriate status of autophagy. In this study, Sin3 was identified as a transcriptional repressor of ATGs and a negative regulator of autophagy induction in Magnaporthe oryzae, a rice fungal pathogen. The loss of SIN3 resulted in upregulated expression of ATGs and increased autophagy. Sin3 negatively regulated the transcription of ATG1, ATG13, and ATG17 through direct occupancy and changes in histone acetylation levels. Under nutrient-deficient conditions, the downregulation of SIN3 and dissociation of Sin3 from ATGs resulted in histone hyperacetylation, activating their transcription and promoting autophagy. This study uncovers a new mechanism of Sin3 in modulating autophagy through transcriptional regulation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.
Review
Medicine, Research & Experimental
Zhengke Wang, Yu Tina Zhao, Ting C. Zhao
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. Histone deacetylases (HDACs) play a crucial role in epigenetic regulation of genetic transcription during stress or pathological conditions, making them a potential target for treating cardiac diseases. Further understanding HDACs can lead to new therapeutic strategies in cardiovascular disorders.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Namin Duan, Xiaohui Hu, Huiran Qiu, Rui Zhou, Yuru Li, Wenxia Lu, Yamin Zhu, Shuang Shen, Wenhui Wu, Feifei Yang, Ning Liu
Summary: In this study, a novel and efficient HDAC1 inhibitor called HR488B was found to exhibit effective anti-colorectal cancer (CRC) activity. HR488B induced cell cycle arrest and apoptosis in CRC cells by causing mitochondrial dysfunction, reactive oxygen species (ROS) generation, and DNA damage accumulation. Furthermore, HR488B suppressed the growth of CRC cells by decreasing the expression of E2F1 and preventing its release from the E2F1/Rb/HDAC1 complex. Therefore, HR488B may be a potential candidate for CRC therapy and targeting the E2F1/Rb/HDAC1 axis shows promise as a therapeutic approach for CRC.
CELL DEATH & DISEASE
(2023)