Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

(2011) Cheryl J. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis

(2010) Yong Xu et al.   Cell Metabolism

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

(2010) Laurence E. Ring et al.   JOURNAL OF CLINICAL INVESTIGATION

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

(2009) Janette H. Quennell et al.   ENDOCRINOLOGY

Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity

(2009) Nicole H. Rogers et al.   ENDOCRINOLOGY

Development of Diabesity in Mice with Neuronal Deletion of Shp2 Tyrosine Phosphatase

(2008) Maryla Krajewska et al.   AMERICAN JOURNAL OF PATHOLOGY

Cross-talk between estrogen and leptin signaling in the hypothalamus

(2008) Qian Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

(2008) X Zhou et al.   HISTOPATHOLOGY

Leptin Stimulates Both JAK2-dependent and JAK2-independent Signaling Pathways

(2008) Lin Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET