The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Activation and Involvement of Ral GTPases in Colorectal Cancer

(2011) T. D. Martin et al.   CANCER RESEARCH

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

Invadosome regulation by adhesion signaling

(2011) Olivier Destaing et al.   CURRENT OPINION IN CELL BIOLOGY

Ras Effector Switching Promotes Divergent Cell Fates in C. elegans Vulval Patterning

(2011) Tanya P. Zand et al.   DEVELOPMENTAL CELL

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

(2011) Hideki Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation

(2011) M. Kuroiwa et al.   JOURNAL OF CELL SCIENCE

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

PIK3CA Mutations Frequently Coexist with RAS and BRAF Mutations in Patients with Advanced Cancers

(2011) Filip Janku et al.   PLoS One

Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms

(2010) Dominico Vigil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sec5 and Exo84 Foster Oncogenic Ras-Mediated Tumorigenesis

(2010) S. H. Issaq et al.   MOLECULAR CANCER RESEARCH

The RalB-RLIP76 Complex Reveals a Novel Mode of Ral-Effector Interaction

(2010) R. Brynmor Fenwick et al.   STRUCTURE

Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix

(2009) Roberto Buccione et al.   CANCER AND METASTASIS REVIEWS

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

(2009) Anurag Singh et al.   CANCER CELL

ADP-Ribosylation Factor 6 Regulates Tumorigenic and Invasive Properties In vivo

(2009) V. Muralidharan-Chari et al.   CANCER RESEARCH

Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

(2009) Claudia Scholl et al.   CELL

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

(2009) K.-H. Lim et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of the Exocyst in Matrix Metalloproteinase Secretion and Actin Dynamics during Tumor Cell Invadopodia Formation

(2009) Jianglan Liu et al.   MOLECULAR BIOLOGY OF THE CELL

K-Ras Promotes Angiogenesis Mediated by Immortalized Human Pancreatic Epithelial Cells through Mitogen-Activated Protein Kinase Signaling Pathways

(2009) Y. Matsuo et al.   MOLECULAR CANCER RESEARCH

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

RLIP76: A novel glutathione-conjugate and multi-drug transporter

(2008) Sharad S. Singhal et al.   BIOCHEMICAL PHARMACOLOGY

Mapping proteolytic cancer cell-extracellular matrix interfaces

(2008) Katarina Wolf et al.   CLINICAL & EXPERIMENTAL METASTASIS

Assembly and biological role of podosomes and invadopodia

(2008) Mario Gimona et al.   CURRENT OPINION IN CELL BIOLOGY

Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs

(2008) Ilaria Cascone et al.   EMBO JOURNAL

TGF-β induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways

(2008) Shyamali Mandal et al.   EXPERIMENTAL CELL RESEARCH

The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA

(2008) Mika Sakurai-Yageta et al.   JOURNAL OF CELL BIOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE