Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells

How do real tumors become resistant to cisplatin?

(2011) Piet Borst et al.   CELL CYCLE

Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blocked

(2011) Simon F. Scrace et al.   CELL CYCLE

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells

(2010) Shilpa Tyagi et al.   BIOCHEMICAL PHARMACOLOGY

Targeting Polo-like Kinase in Cancer Therapy

(2010) Y. Degenhardt et al.   CLINICAL CANCER RESEARCH

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

(2010) T. G. Oliver et al.   GENES & DEVELOPMENT

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

A Specific Form of Phospho Protein Phosphatase 2 Regulates Anaphase-promoting Complex/Cyclosome Association with Spindle Poles

(2010) Jorge Z. Torres et al.   MOLECULAR BIOLOGY OF THE CELL

A Fine-Needle Aspirate-Based Vulnerability Assay Identifies Polo-Like Kinase 1 as a Mediator of Gemcitabine Resistance in Pancreatic Cancer

(2010) A. Jimeno et al.   MOLECULAR CANCER THERAPEUTICS

Decoding signalling networks by mass spectrometry-based proteomics

(2010) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

The effect of cisplatin on human larynx carcinoma cell motility.

(2009) Roman Paduch et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Macroscopic Differences in HMGA Oncoproteins Post-Translational Modifications: C-Terminal Phosphorylation of HMGA2 Affects Its DNA Binding Properties

(2009) Riccardo Sgarra et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of transcription by platinum antitumor compounds

(2009) Ryan C. Todd et al.   Metallomics

A Dual Pressure Linear Ion Trap Orbitrap Instrument with Very High Sequencing Speed

(2009) Jesper V. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Global analysis of the yeast osmotic stress response by quantitative proteomics

(2009) Boumediene Soufi et al.   Molecular BioSystems

Platinum neurotoxicity pharmacogenetics

(2009) S. R. McWhinney et al.   MOLECULAR CANCER THERAPEUTICS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A practical guide to the MaxQuant computational platform for SILAC-based quantitative proteomics

(2009) Jürgen Cox et al.   Nature Protocols

Global and Site-Specific Quantitative Phosphoproteomics: Principles and Applications

(2008) Boris Macek et al.   Annual Review of Pharmacology and Toxicology

DNA repair in murine embryonic stem cells and differentiated cells

(2008) Elisia D. Tichy et al.   EXPERIMENTAL CELL RESEARCH

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

(2008) Youssef H. Zeidan et al.   JOURNAL OF CELL BIOLOGY

Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors

(2008) Klaus Mross et al.   JOURNAL OF CLINICAL ONCOLOGY

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

(2008) Zheng Fu et al.   NATURE CELL BIOLOGY

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

(2007) Matthew D. Hall et al.   Annual Review of Pharmacology and Toxicology