Review
Biochemistry & Molecular Biology
Jiani Liang, Margot Chirikjian, Utpal B. Pajvani, Alberto Bartolome
Summary: The expression of MafA, a key transcription factor, is decreased in type 2 diabetes, leading to beta-cell dysfunction. Understanding the regulatory factors of MafA expression may help identify potential therapeutic targets for improving beta-cell function.
Article
Oncology
Huan-Lei Wu, Sen-Mao Li, Yao-chen Huang, Qi-Dong Xia, Peng Zhou, Xian-Miao Li, Xiao Yu, Shao-Gang Wang, Zhang-Qun Ye, Jia Hu
Summary: Our study found that HnRNPK plays an important role in the carcinogenesis process of prostate cancer. miR-206 and miR-613 suppress HnRNPK expression by targeting its 3'-UTR in PrCa cell lines. Additionally, Cullin 3 SPOP acts as a novel upstream E3 ubiquitin ligase complex that promotes the degradation of HnRNPK in a polyubiquitination-dependent proteolysis manner.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Ayumi Kuga, Kouhei Tsuchida, Harit Panda, Makoto Horiuchi, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Mikiko Suzuki, Masayuki Yamamoto
Summary: Nrf2 activity is regulated by the Keap1-mediated and beta-TrCP-mediated pathways. When Keap1 activity is suppressed, the beta-TrCP-mediated pathway cooperates with the Keap1-mediated pathway to increase Nrf2 activity, resulting in severe growth retardation and esophageal epithelial abnormalities.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Bu, Xuan Qu, Kai Guo, Xiangliang Meng, Xing Yang, Qike Huang, Wenjie Dou, Lin Feng, Xinxin Wei, Jiwei Gao, Wei Sun, Min Chao, Liying Han, Yaqin Hu, Liangliang Shen, Jian Zhang, Liang Wang
Summary: CD147 overexpression contributes to TMZ resistance in glioma cells through post-translational regulation of Nrf2 expression. Suppression of CD147 expression enhances the inhibitory effect of TMZ on cell survival by inhibiting GSK3 beta/beta-TrCP-dependent Nrf2 degradation and increasing Nrf2-mediated anti-oxidant gene expressions. Targeting CD147/Nrf2 axis may provide a new strategy for the treatment of TMZ resistant gliomas.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemical Research Methods
Mattia Furlan, Stefano de Pretis, Mattia Pelizzola
Summary: Despite RNA abundance being commonly assumed as a proxy for transcriptional activity, it is now possible to calculate how synthesis, processing, and degradation rates collectively determine the abundance of each gene's RNA. Different transcriptional outputs can correspond to different combinations of kinetic rates, indicating the existence of markedly different modes of gene expression regulation and their profound effects on gene self-expression regulation.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Cell Biology
Sara S. Procknow, Beth A. Kozel
Summary: Elastin provides elasticity to tissues such as the lung, blood vessels, and skin, but the mechanisms regulating its production are not fully understood. Studying the expression of the ELN gene may help intervene in rare diseases and potentially replace age-related losses by re-initiating elastin production.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nozomu Takata, Jason M. Miska, Marc A. Morgan, Priyam Patel, Leah K. Billingham, Neha Joshi, Matthew J. Schipma, Zachary J. Dumar, Nikita R. Joshi, Alexander V. Misharin, Ryan B. Embry, Luciano Fiore, Peng Gao, Lauren P. Diebold, Gregory S. McElroy, Ali Shilatifard, Navdeep S. Chandel, Guillermo Oliver
Summary: Using eye organoids and mouse models, the authors demonstrate that lactate plays a bioenergetic independent role as a cell signaling molecule during early eye formation in mice. The study reveals the importance of aerobic glycolysis in retinal development and identifies specific glucose transporters and glycolytic genes involved. Lactate-mediated upregulation of eye-field transcription factors is controlled by epigenetic modifications.
NATURE COMMUNICATIONS
(2023)
Article
Pediatrics
Dan Wang, Mengqing Xu, Linlin Huang, Xueting Wang, Li Zhu
Summary: This study revealed that NRF1 overexpression can restore the expression of glutamatergic genes and improve cognitive impairment caused by neonatal HIE. NRF1 regulates the expression of mGluRs and iGluRs and activates their transcription by binding to the promoter regions.
PEDIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein
Summary: DEPTOR is a protein upregulated in multiple myeloma cells, which inhibits mTOR and promotes AKT activation. This study found that the phosphorylation of DEPTOR at serine 235 regulates its stability, and the association of USP-7 with DEPTOR depends on S235 phosphorylation. In addition, the ERK1 pathway maintains AKT activity through phosphorylation of DEPTOR.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Gary Ruvkun, Nicolas Lehrbach
Summary: Nrf1, a member of the nuclear erythroid-2-like family of transcription factors, regulates stress-responsive gene expression in animals. Newly synthesized Nrf1 is first glycosylated in the endoplasmic reticulum (ER), then trafficked to the cytosol by ER-associated degradation (ERAD) machinery for rapid proteasomal degradation.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2023)
Article
Neurosciences
Sarah Belhocine, Andre Machado Xavier, Felix Distefano-Gagne, Stephanie Fiola, Serge Rivest, David Gosselin
Summary: The study found that regulation of cell cycle gene expression in mouse microglia can be coordinated through two different mechanisms. One mechanism increases the expression of genes already expressed in quiescent microglia, regulated by Klf/Sp, Nfy, and Ets transcription factors; while another mechanism allows for de novo transcription of cell cycle genes, requiring additional regulatory input from Lin54 and E2f transcription factors.
Article
Biochemistry & Molecular Biology
Kei Taguchi, Masayuki Kaneko, Serika Motoike, Kana Harada, Izumi Hide, Shigeru Tanaka, Norio Sakai
Summary: The ubiquitin E3 ligase HRD1 is demonstrated to be involved in the degradation of SERT protein, promoting SERT ubiquitination and affecting its uptake activity. This involvement in endoplasmic reticulum-associated degradation contributes to the membrane trafficking and functional regulation of SERT.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Moshe Katz, Suraj Subramaniam, Orna Chomsky-Hecht, Vladimir Tsemakhovich, Veit Flockerzi, Enno Klussmann, Joel A. Hirsch, Sharon Weiss, Nathan Dascal
Summary: CaV1.2 channels play a crucial role in regulating cardiac muscle contraction, with 0-AR increasing contraction by enhancing calcium influx through these channels via PKA activation. A recent study identified Rad as essential for PKA regulation of CaV1.2, revealing two distinct pathways of PKA modulation of CaV1.2: Rad dependent and Rad independent.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Yoshihiko Furuike, Atsushi Mukaiyama, Shin-Ichi Koda, Damien Simon, Dongyan Ouyang, Kumiko Ito-Miwa, Shinji Saito, Eiki Yamashita, Taeko Nishiwaki-Ohkawa, Kazuki Terauchi, Takao Kondo, Shuji Akiyama
Summary: KaiC is a dual ATPase that drives the circadian clock system of cyanobacteria through the coordination of its N-terminal and C-terminal active sites. The activities of these two sites are regulated differently and their delicate interactions drive the assembly and disassembly cycle of KaiA and KaiB.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Peripheral Vascular Disease
Shan Jiang, Guijuan Chen, Zhihui Yang, Dan Wang, Yapeng Lu, Li Zhu, Xueting Wang
Summary: Hypoxia-induced hypertension in rats is associated with increased levels of Ang-2 and ET-1, along with decreased NO levels. Physiological testosterone has a protective effect on blood pressure by inhibiting NRF1 and reducing levels of Ang-2 and ET-1. NRF1 plays a critical role in regulating ACE and ET-1 expression in endothelial cells under hypoxic conditions.
HYPERTENSION RESEARCH
(2021)
Letter
Biotechnology & Applied Microbiology
Nozomu Yachie, Tohru Natsume, Koichi Takahashi, Toshiaki Katayama, Takeshi Sakurada, Genki N. Kanda, Eiji Takagi, Takako Hirose, Tatsuo Katsura, Tetsuo Moriya, Hiroaki Kitano, Junichi Tsujii, Tohru Natsume, Tomoyuki Shiraki, Hirokazu Kariyazaki, Motohisa Kamei, Noriko Abe, Takuya Fukuda, Yukiko Sawada, Yukio Hashiguchi, Kenji Matsukuma, Shinji Murai, Naoyuki Sasaki, Tatsuro Ipposhi, Hideo Urabe, Taku Kudo, Makoto Umeno, Seiki Ono, Kohei Miyauchi, Miki Nakamura, Takahiro Kizaki, Takashi Suyama, Tomohisa Hatta, Tohru Natsume, Tazro Ohta, Koichi Takahashi, Yosuke Ozawa, Nozomu Yachie, Takeshi Sakurada, Kenji Matsukuma, Shinji Murai, Shoji Ihara, Satoshi Tamaki, Erick Antezana, Alexander Garcia-Castro, Jean-Luc Perret, Soh Ishiguro, Hideto Mori, Daniel Evans-Yamamoto, Nanami Masuyama, Masaru Tomita, Junichi Tsujii, Toshiaki Katayama, Hiroaki Kitano, Tomohisa Hatta, Masaki Matsumoto, Hiroshi Nakayama, Ayaka Shirasawa, Kazutaka Shimbo, Naoyuki Yamada, Keiichi I. Nakayama, Tohru Natsume, Takatsune Shimizu, Hideyuki Saya, Satoshi Yamashita, Takahide Matsushima, Hiroshi Asahara, Hidetoshi Eguchi, Manabu Mikamori, Masaki Mori
NATURE BIOTECHNOLOGY
(2017)
Article
Multidisciplinary Sciences
Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai, Nobutaka Hattori
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi
NATURE COMMUNICATIONS
(2017)
Article
Cell Biology
Yusuke Hirata, Kazumi Katagiri, Keita Nagaoka, Tohru Morishita, Yuki Kudoh, Tomohisa Hatta, Isao Naguro, Kuniyuki Kano, Tsuyoshi Udagawa, Tohru Natsume, Junken Aoki, Toshifumi Inada, Takuya Noguchi, Hidenori Ichijo, Atsushi Matsuzawa
Article
Biochemistry & Molecular Biology
Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M. Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba
Article
Biochemistry & Molecular Biology
Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M. Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba
Article
Biology
Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara
Article
Multidisciplinary Sciences
Yuri Kotani, Daisuke Morito, Kenshiro Sakata, Shiori Ainuki, Munechika Sugihara, Tomohisa Hatta, Shun-ichiro Iemura, Seiji Takashima, Tohru Natsume, Kazuhiro Nagata
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
A. M. Masudul Azad Chowdhury, Hiroki Katoh, Atsushi Hatanaka, Hiroko Iwanari, Nanami Nakamura, Takao Hamakubo, Tohru Natsume, Tsuyoshi Waku, Akira Kobayashi
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Shiori Aono, Ayari Hatanaka, Atsushi Hatanaka, Yue Gao, Yoshitaka Hippo, Makoto Mark Taketo, Tsuyoshi Waku, Akira Kobayashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Oncology
Akira Kobayashi, Tsuyoshi Waku
Review
Oncology
Akira Kobayashi
Review
Biochemistry & Molecular Biology
Tsuyoshi Waku, Akira Kobayashi
Summary: NRF3 plays a crucial role in regulating transcriptional axes for protein and lipid homeostasis, contributing to anti-cancer responses with a potential role in obesity-induced cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hiroaki Taniguchi, Shota Okamuro, Misaki Koji, Tsuyoshi Waku, Kaori Kubo, Atsushi Hatanaka, Yimeng Sun, A. M. Masudul Azad Chowdhury, Akiyoshi Fukamizu, Akira Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)