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Huiqi Yin, Zhenlong Kang, Yingwen Zhang, Yingyun Gong, Mengrou Liu, Yanfeng Xue, Wenxiu He, Yanfeng Wang, Shuya Zhang, Qiushi Xu, Kaiqiang Fu, Bangjin Zheng, Jie Xie, Jinwen Zhang, Yuanyuan Wang, Mingyan Lin, Yihan Zhang, Hua Feng, Changpeng Xin, Yichun Guan, Chaoyang Huang, Xuejiang Guo, P. Jeremy Wang, Joseph A. Baur, Ke Zheng, Zheng Sun, Lan Ye
Summary: The study identifies HDAC3 as a key regulator in spermatogenesis, where it represses meiotic/spermatogonial genes and activates postmeiotic haploid gene programs during the meiotic exit. Unexpectedly, abolishing HDAC3 catalytic activity does not affect fertility, demonstrating that HDAC3 enzyme activity is not required for spermatogenesis. Motif analysis of the HDAC3 cistrome in the testes identified SOX30 as a key regulator in the transcriptional program during the meiotic-to-postmeiotic transition in spermatogenesis.
NUCLEIC ACIDS RESEARCH
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Jiahui Du, Junjun Jing, Shuo Chen, Yuan Yuan, Jifan Feng, Thach-Vu Ho, Prerna Sehgal, Jian Xu, Xinquan Jiang, Yang Chai
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Biochemistry & Molecular Biology
Janardan N. Gavade, Chris M. Puccia, S. Grace Herod, Jonathan C. Trinidad, Luke E. Berchowitz, Soni Lacefield
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Agnieszka Wegrzyn, Avtandil Tsurtsumia, Stefan Witkowski, Olga Freitas, Sonia Figueiredo, Joanna Cybinska, Wojciech Stawinski
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Gabriel M. Gihana, Arthur A. Cross-Najafi, Soni Lacefield
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Biochemistry & Molecular Biology
Jelena Micic, Olga Rodriguez-Galan, Reyes Babiano, Fiona Fitzgerald, Jose Fernandez-Fernandez, Yunyang Zhang, Ning Gao, John L. Woolford, Jesus de la Cruz
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NUCLEIC ACIDS RESEARCH
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Jeremy Scutenaire, Damien Plassard, Melody Matelot, Tommaso Villa, Julie Zumsteg, Domenico Libri, Bertrand Seraphin
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NUCLEIC ACIDS RESEARCH
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Amy Sirr, Martin S. Timour, Gareth A. Cromie, Michelle Tang, Aimee M. Dudley
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Abhimannyu Rimal, Thomas M. Swayne, Zeal P. Kamdar, Madison A. Tewey, Edward Winter
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