Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-Han Lin, Maryann P. Platt, Ryan P. Gilley, David Brown, Peter H. Dube, Yanbao Yu, Norberto Gonzalez-Juarbe
Summary: This study found significant alterations in the cardiac proteome and phosphoproteome after pulmonary influenza infection, with viral particles persisting in the heart. Inhibition of necroptosis or prevention of mitochondrial damage may be potential therapeutic interventions to reduce cardiac damage during influenza infections.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Danilo Martins, Leonardo Rufino Garcia, Diego Aparecido Rios Queiroz, Taline Lazzarin, Carolina Rodrigues Tonon, Paola da Silva Balin, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Leonardo Zornoff
Summary: Cardiac remodeling refers to a series of molecular, cellular, and interstitial changes in the heart that occur after different stimuli, manifesting clinically as changes in size, mass, geometry, and function. Remodeling plays a crucial pathophysiological role in the onset and progression of ventricular dysfunction. The role of oxidative stress as a therapeutic target for cardiac remodeling has been gaining attention in recent years.
Article
Pharmacology & Pharmacy
Maria Paz Ocaranza, Jorge E. Jalil, Rodrigo Altamirano, Ana de Leon, Jackeline Moya, Alejandra Lonis, Luigi Gabrielli, Paul Mac Nab, Samuel Cordova, Alejandro Paredes, Ismael Vergara, Alex Bittner, Karime Sabat, Karla Pastorini
Summary: In patients with heart failure, effective cardiac resynchronization therapy induced reverse myocardial remodeling over three months, with significantly decreased ROCK activation in circulating leukocytes. This suggests that reduced ROCK activation in circulating leukocytes may reflect reverse cardiac remodeling in heart failure patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Junling Pang, Ting Shu, Meijun Zhao, Yaqin Tang, Zhiwei Li, Baicun Li, Cuiliu Hou, Xiaomin Song, Aoxue Wu, Xiaoxiao Guo, Si Chen, Bin Liu, Chen Yan, Jing Wang
Summary: The study found that IgE plays a causative role in pathological cardiac remodeling, at least partially through activating IgE-Fc epsilon R1 signaling in cardiomyocytes and cardiac fibroblasts. Therapeutic strategies targeting the IgE-Fc epsilon R1 axis may be effective for managing IgE-mediated cardiac remodeling.
Review
Biology
Sabina Andreea Leanca, Irina Afrasanie, Daniela Crisu, Iulian Theodor Matei, Stefania Teodora Duca, Alexandru Dan Costache, Viviana Onofrei, Ionut Tudorancea, Ovidiu Mitu, Minerva Codruta Badescu, Lacramioara Ionela Serban, Irina Iuliana Costache
Summary: Despite improvements in CAD and MI treatment, IHD remains the leading cause of HF, with over 70% of HF patients having IHD as the underlying cause. IHD also leads to worse outcomes, increased morbidity and mortality, and higher healthcare costs. New pharmacological therapies and interventional strategies have shown potential benefits in reducing symptoms and promoting reverse remodeling in HF patients. Cardiac regenerative therapies, such as stem cell transplantation, could also be a new therapeutic resource for managing HF. This review aims to analyze existing data to evaluate the impact of new HF therapies in IHD patients and gain insight into optimal management strategies for this large proportion of HF patients.
Article
Cardiac & Cardiovascular Systems
Sean P. Murphy, Margaret F. Prescott, Alan S. Maisel, Javed Butler, Ileana L. Pina, G. Michael Felker, Jonathan H. Ward, Kristin M. Williamson, Alexander Camacho, Ritvik R. Kandanelly, Scott D. Solomon, James L. Januzzi
Summary: In this study, heart failure patients with reduced ejection fraction undergoing sacubitril/valsartan treatment for 12 months showed significant reductions in concentrations of NT-proBNP, hs-cTnT, and sST2. Changes in NT-proBNP and hs-cTnT were associated with left atrial and left ventricular reverse remodeling.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
William W. Du, Jindong Xu, Weining Yang, Nan Wu, Feiya Li, Le Zhou, Sheng Wang, Xiangmin Li, Alina T. He, Kevin Y. Du, Kaixuan Zeng, Jian Ma, Juanjuan Lyu, Chao Zhang, Chi Zhou, Katarina Maksimovic, Burton B. Yang
Summary: The upregulation of circNlgn in patients with cardiac disease leads to cardiac overload. The novel peptide Nlgn173 binds to nuclear structural proteins and regulators, ultimately contributing to cardiac fibrosis and heart disease. Therapeutic implications may be derived from understanding this dysregulation mechanism.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal
Summary: The study highlights the inhibitory effects of Apilimod on cardiac fibrotic remodeling, controlling the TGF beta signaling pathway to prevent adverse remodeling. It also suggests a novel function for PIKfyve in regulating myocardial fibrosis and TGF beta pathway.
Article
Cardiac & Cardiovascular Systems
Lisa E. Dorn, William Lawrence, Jennifer M. Petrosino, Xianyao Xu, Thomas J. Hund, Bryan A. Whitson, Matthew S. Stratton, Paul M. L. Janssen, Peter J. Mohler, Anders Schlosser, Grith L. Sorensen, Federica Accornero
Summary: This study identified a novel role for nonmyocyte-derived MFAP4 in cardiac remodeling, playing a crucial role in cardiac adaptation to stress. Lack of MFAP4 resulted in increased cardiac hypertrophy, worsened cardiac function, and dysregulated G protein-coupled receptor and integrin signaling in the heart.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mark Sweeney, Katie O'Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei-Wen Lim, Anissa Widjaja, Paul J. R. Barton, Stuart A. Cook
Summary: This study demonstrates that IL11 expression in cardiomyocytes can lead to severe cardiac fibrosis and inflammation, as well as endothelial-to-mesenchymal transition and left ventricular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
Review
Biochemistry & Molecular Biology
Taline Lazzarin, Leonardo Rufino Garcia, Danilo Martins, Diego Aparecido Rios Queiroz, Carolina Rodrigues Tonon, Paola da Silva Balin, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Paula Schmidt Azevedo, Marcos Minicucci, Leonardo Zornoff
Summary: This review evaluates the role of nutrients and food as modulators of cardiac remodeling. Remodeling is associated with increased risk of heart disease, and antioxidative dietary compounds potentially have protective properties.
Article
Cardiac & Cardiovascular Systems
Yuxuan Guo, Yangpo Cao, Blake D. Jardin, Xiaoran Zhang, Pingzhu Zhou, Silvia Guatimosim, Junsen Lin, Zhan Chen, Yueyang Zhang, Neil Mazumdar, Fujian Lu, Qing Ma, Yao-Wei Lu, Mingming Zhao, Da-Zhi Wang, Erdan Dong, William T. Pu
Summary: The aim of this study is to investigate the role of RYR2 in cardiomyocyte maturation. The researchers used genetic editing techniques to knockout RYR2 and found that its depletion led to structural and transcriptional defects in cardiomyocytes, along with activation of ER stress pathways. The defects in RYR2-depleted cardiomyocytes were partially rescued by an ER stress alleviator.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cell Biology
Itamar Couto Guedes Jesus, Thassio Mesquita, Robson Augusto Souza Santos, Silvia Guatimosim
Summary: The renin-angiotensin system (RAS) plays a crucial role in various cardiovascular functions. Angiotensin II, as one of the key peptides in this system, contributes to heart failure in pathological conditions. However, another RAS peptide, angiotensin-(1-7), exhibits therapeutic effects in different types of cardiac diseases. Recently, alamandine and its receptor, MrgD, have been discovered as new components of RAS, and their physiological and pathological functions in the heart, especially in cardiomyocytes, have been extensively studied.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Diego Faria, Renata J. Moll-Bernardes, Laura Testa, Camila M. V. Moniz, Erika C. Rodrigues, Amanda G. Rodrigues, Amanda Araujo, Maria J. N. N. Alves, Bruna E. Ono, Joao E. Izaias, Vera M. C. Salemi, Camila P. Jordao, Graziela Amaro-Vicente, Maria U. P. B. Rondon, Katelyn R. Ludwig, Daniel H. Craighead, Matthew J. Rossman, Fernanda M. Consolim-Colombo, Katia De Angelis, Maria C. C. Irigoyen, Douglas R. Seals, Carlos E. Negrao, Allan R. K. Sales
Summary: COVID-19 survivors exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, and reduced exercise capacity compared to controls. Further investigation is needed to determine whether these manifestations are persistent longer-term and their impact on the cardiovascular health of COVID-19 survivors.
Article
Biotechnology & Applied Microbiology
Maria Clara Selles, Juliana T. S. Fortuna, Magali C. Cercato, Luis Eduardo Santos, Luciana Domett, Andre L. B. Bitencourt, Mariane Favero Carraro, Amanda S. Souza, Helena Janickova, Caroline Vieira Azevedo, Henrique Correia Campos, Jorge M. de Souza, Soniza Alves-Leon, Vania F. Prado, Marco A. M. Prado, Alberto L. Epstein, Anna Salvetti, Beatriz Monteiro Longo, Ottavio Arancio, William L. Klein, Adriano Sebollela, Fernanda G. De Felice, Diana A. Jerusalinsky, Sergio T. Ferreira
Summary: The accumulation of ADOs in the brain is associated with synapse failure and memory impairment in Alzheimer's disease. Treatment with NUsc1, a selectively targeting antibody, prevents the inhibition of long-term potentiation and memory impairment induced by ADOs in mice. The gene delivery of NUsc1 through adeno-associated virus vector shows therapeutic potential in preventing and reversing memory deficits in Alzheimer's disease.
Article
Pharmacology & Pharmacy
Marina Ayres Delgado, Luana Assis Ferreira, Marcio Junior Rezende, Marcus Vinicius Gomez, Celio Jose Castro-Junior
Summary: Combining drugs with different mechanisms of action can result in opioid-sparing strategies in pain management. This study demonstrates that the combination of ketamine and lidocaine synergistically attenuates thermal and inflammatory pain, allowing for lower doses of both drugs while maintaining their analgesic efficacy and minimizing motor activity alterations.
ADVANCED THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Julia M. Assini, Justin R. Clark, Amer Youssef, Chuce Xing, Alexandria M. Doerfler, So Hyun Park, Lavanya Saxena, Adam B. Yaseen, Jan Boren, Robert Gros, Gang Bao, William R. Lagor, Michael B. Boffa, Marlys L. Koschinsky
Summary: Lp(a) has been shown to contribute to the development of more severe atherosclerotic lesions, especially in female mice. This suggests a potential pro-inflammatory role of Lp(a) in atherosclerosis.
Article
Pharmacology & Pharmacy
Jorge Lucas Teixeira-Fonseca, Michael Ramon de Lima Conceicao, Polyana Leal-Silva, Danilo Roman-Campos
Summary: The study uses a rat model to investigate the effect of ranolazine on atrial arrhythmias and finds that ranolazine, with its multichannel blocking properties, can effectively treat these arrhythmias.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Andrew J. Lawrence, Marco A. M. Prado
Summary: This editorial discusses how the Journal of Neurochemistry plans to implement Transparent Peer Review in order to improve the publishing experience and value for the scientific community.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Chemistry, Medicinal
Edinildo de Oliveira Rodrigues Junior, Izabel Rodrigues de Santana, Aimee Obolari Durco, Lino Sergio Rocha Conceicao, Andre Sales Barreto, Igor Alexandre Cortes Menezes, Danilo Roman-Campos, Marcio Roberto Viana dos Santos
Summary: Sepsis is a dysregulated immune response to infection that can lead to organ failure and death. Flavonoids, a class of plant metabolites, have been found to have beneficial effects in the treatment of sepsis. This study reviewed the effects of flavonoids on experimental sepsis, focusing on survival rate and mechanisms of action. The meta-analysis showed that flavonoids significantly increased the survival rate of animals and exhibited anti-inflammatory, antioxidant, antibacterial, and anti-apoptotic properties. Flavonoids may be a promising therapeutic alternative for reducing complications and improving survival in sepsis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Instruments & Instrumentation
Ana Luiza de Castro Santos, Natalia Jordana Alves da Silva, Celso Tarso Rodrigues Viana, Leticia Cristine Cardoso dos Santos, Gabriel Henrique Costa da Silva, Sergio Ricardo Aluotto Scalzo Junior, Pedro Augusto Carvalho Costa, Walison Nunes da Silva, Itamar Couto Guedes de Jesus, Alexander Birbrair, Mariana T. Q. de Magalhaes, Frederic Frezard, Silvia Guatimosim, Rebecca M. Haley, Michael J. Mitchell, Silvia Passos Andrade, Paula Peixoto Campos, Pedro Pires Goulart Guimaraes
Summary: This study investigated the effects of the Wnt inhibitor complex CD: LGK974 on reducing the inflammatory, fibrotic, and angiogenic processes caused by intraperitoneal implants. The results showed that CD: LGK974 significantly reduced immune cell infiltration, inflammatory cytokine release, collagen deposition, and expression of pro-fibrotic markers. It also decreased VEGF levels and inhibited blood vessel formation. These findings suggest that the use of the Wnt inhibitor complex may be a potential strategy to reduce peritoneal fibrosis and implant rejection.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sara Memar, Eric Jiang, Vania F. Prado, Lisa M. Saksida, Timothy J. Bussey, Marco A. M. Prado
Summary: Open access to rodent cognitive data has been lagging behind other areas of neuroscience, but the use of touchscreen-automated cognitive testing in animal models provides standardized outputs that can be easily shared. These datasets can be combined with various neuro-technologies to analyze the relationship between neural activity and behavior. MouseBytes is a web-based repository that allows researchers to store, share, visualize, and analyze cognitive data, while MouseBytes+ integrates complementary neuro-technology data for multi-modal behavioral analysis.
Article
Computer Science, Artificial Intelligence
Joao Vitor Firmino, Marcelo Melo, Vera Salemi, Kamilla Bringel, Davi Leone, Renner Pereira, Marcelo Rodrigues
Summary: Heart failure is a clinical syndrome that impairs the heart's ability to effectively pump blood or leads to elevated intracardiac pressures. A new research presents the development of artificial neural networks (ANNs) that recognize vocal distortions caused by heart failure. Voices of 142 individuals, including those diagnosed with HF and healthy individuals, were collected and analyzed using various techniques. The developed ANNs achieved an efficiency of 96.7% and showed promising accuracy, sensitivity, and specificity values for HF identification.
EVOLUTIONARY INTELLIGENCE
(2023)
Article
Clinical Neurology
Liliana German-Castelan, Hayley R. C. Shanks, Robert Gros, Takashi Saito, Takaomi C. Saido, Lisa M. Saksida, Timothy J. Bussey, Marco A. M. Prado, Taylor W. Schmitz, Vania F. Prado
Summary: The relationship between cholinergic signaling and amyloid pathology in Alzheimer's Disease (AD) is causally modulated by biological sex, as observed in male mice and ovariectomized female mice. However, this relationship is decoupled in ovary-intact and ovariectomized females receiving estradiol. In elderly individuals, cholinergic loss exacerbates amyloid beta (A beta).
ALZHEIMERS & DEMENTIA
(2023)
Article
Pharmacology & Pharmacy
Jorge Lucas Teixeira-Fonseca, Julliane Vasconcelos Joviano-Santos, Fabiana da Silva Alcantara, Michael Ramon de Lima Conceicao, Polyana Leal-Silva, Danilo Roman-Campos
Summary: Atrial arrhythmias are common and associated with poor outcomes in pulmonary hypertension. Little is known about right atrium function and propensity to arrhythmias in the monocrotaline-induced pulmonary hypertension (MCT-PH) rat model. This study aimed to evaluate the function of the right atrium in control and MCT-treated rats, and the ability of amiodarone to prevent arrhythmias in MCT-PH rats. The results showed that MCT-PH impairs right atrium structure and function, and amiodarone does not attenuate the onset of arrhythmias in the ex vivo right atrium.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Andreza Melo de Araujo, Sandra Valeria Santos de Cerqueira, Jose Evaldo Rodrigues de Menezes-Filho, Luana Heimfarth, Katharina Kelly de Oliveira Gama Matos, Karina Oliveira Mota, Michael Ramon de Lima Conceicao, Leisiane Pereira Marques, Danilo Roman-Campos, Agenor Gomes dos Santos-Neto, Ricardo Luiz Cavalcanti de Albuquerque-Junior, Vinicius Cisneiros de Oliveira Santos, Carla Maria Lins de Vasconcelos
Summary: Naringin (NRG) has a cardioprotective effect against ischemia-reperfusion (I/R) injury by reducing oxidative stress, apoptosis, and activating the KATP channels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)