Article
Immunology
Lu Yao, Yanjun Gu, Tianyi Jiang, Huilian Che
Summary: This study found that activating PPAR-gamma can alleviate clinical symptoms and immune reactions in food allergies. Activation of PPAR-gamma can mitigate food allergies by enhancing intestinal mucosal integrity and tight junctions, and inhibiting mast cell degranulation. Furthermore, PPAR-gamma activation can also inhibit PAK1 phosphorylation and p65 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Omar Elakad, Bjoern Haeupl, Vera Labitzky, Sha Yao, Stefan Kueffer, Alexander von Hammerstein-Equord, Bernhard C. Danner, Manfred Juecker, Henning Urlaub, Tobias Lange, Philipp Stroebel, Thomas Oellerich, Hanibal Bohnenberger
Summary: This study identified a CD44/PAK1/AKT signaling axis as a common resistance mechanism to FGFR1 inhibition in lung cancer. The activation levels of CD44/PAK1/AKT could help predict response to FGFR1 inhibition, and the combination of AKT and FGFR1 inhibitors may be effective in treating patients with FGFR1-dependent lung cancer.
NPJ PRECISION ONCOLOGY
(2022)
Article
Cell Biology
Yu-Yang Yi, Hao Chen, Shu-Bao Zhang, Hao-Wei Xu, Xin-Yue Fang, Shan-Jin Wang
Summary: Intervertebral disc degeneration (IDD) is a common problem in the aged population and is closely related to low back pain and spinal disability. The anti-aging drug Klotho has been found to inhibit cell degeneration, improve extracellular matrix degradation, and prevent angiogenesis, potentially acting as a treatment for IDD. This study provides an innovative understanding of the molecular mechanism of IDD.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Cell Biology
Yu-Yang Yi, Hao Chen, Shu-Bao Zhang, Hao-Wei Xu, Xin-Yue Fang, Shan-Jin Wang
Summary: The study reveals that the anti-aging drug Klotho can inhibit the progression of intervertebral disc degeneration by improving extracellular matrix degradation and angiogenesis to maintain the phenotype, viability, and matrix content of nucleus pulposus cells (NPCs).
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Review
Biochemistry & Molecular Biology
Qinghao Yi, Tianze Chen, Kunlin Zhou, Qiang Ma, Zhiyuan Sun, Hengliang Shi
Summary: This study investigates the effects of PAK1 inhibition on the proliferation, migration, and invasion of glioma cells. The results demonstrate that PAK1 inhibition can impede the proliferation, migration, and invasion of glioma cells.
CURRENT PROTEIN & PEPTIDE SCIENCE
(2023)
Article
Oncology
Huimin Bu, Shirui Tan, Bo Yuan, Xiaomei Huang, Jiebang Jiang, Yejiao Wu, Jihong Jiang, Rongpeng Li
Summary: This study reveals that Ipomoea batatas polysaccharides (IBPs) inhibit lung cancer cell proliferation by inducing cytostatic macroautophagy, suggesting IBP as a potential therapeutic agent for lung cancer treatment.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Oncology
Nor Idayu A. Rahman, Akira Sato, Khurelbaatar Tsevelnorov, Akio Shimizu, Masahiro Komeno, Mohammad Khusni Bin Ahmat Amin, Md Rasel Molla, Joanne Ern Chi Soh, Le Kim Chi Nguyen, Akinori Wada, Akihiro Kawauchi, Hisakazu Ogita
Summary: Stromal-induced stomatin expression in prostate cancer cells suppresses tumor growth by inhibiting the Akt signaling axis, with clinical relevance shown in decreased stomatin levels in high Gleason score prostate cancer samples and higher recurrence rates post-operation.
Review
Cell Biology
Lisa Mueller, Mechthild Hatzfeld, Rene Keil
Summary: Desmosomes are intercellular junctions that preserve tissue integrity by responding to context-dependent signals and transmitting them to change cell behavior. Their composition and size vary depending on tissue specific expression and differentiation state, and their constituent proteins are highly regulated by posttranslational modifications. This review summarizes how signaling pathways control desmosomes to modulate cell behavior.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yeqing Ren, Biao Yang, Geng Guo, Jianping Zhang, Yanqi Sun, Dong Liu, Shihao Guo, Yongqiang Wu, Xiaogang Wang, Shule Wang, Wenju Zhang, Xiaolong Guo, Xuepeng Li, Ren Li, Jianhang He, Zihan Zhou
Summary: GBP2 plays a critical role in glioma by regulating the EGFR signaling pathway and interacting with KIF22, which suggests its potential as a therapeutic target for glioma treatment.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
P. Song, B. Song, J. Liu, X. Wang, X. Nan, J. Wang
Summary: PAK1, downstream of RAC and CDC42 GTPase, is activated by various stimuli including RAS and growth signaling factors. Study shows PAK1 is not only highly expressed in RAS mutant lung cancer cells but also in RAS wild-type cells. Inhibition of PAK1 significantly reduces cell proliferation, migration and invasion in lung cancer cells through ERK and AKT signaling pathways. In NSCLC patients, PAK1 is positively correlated with pERK and pAKT but not with KRAS mutation.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Emergency Medicine
Xiaoxiang Wang, Yinghui Liu, Jia He, Jingru Wang, Xiaodong Chen, Ronghua Yang
Summary: This article reviews the regulation of hair follicles, HFSCs and related signaling pathways, summarizes previous research results, and reveals the regulatory mechanisms of HFSC proliferation and differentiation.
Article
Endocrinology & Metabolism
Vijay K. Sirohi, Theresa Medrano, Ana M. Mesa, Athilakshmi Kannan, Indrani C. Bagchi, Paul S. Cooke
Summary: This study reveals the importance of AKT activation in promoting uterine epithelial proliferation even when it is independent of E2/ESR1 signaling. Additionally, the role of membrane ESR1 in AKT activation is emphasized.
Article
Chemistry, Medicinal
Bo Deng, Xiao-Li Jiang, Zhang-Bin Tan, Min Cai, Sui-Hui Deng, Wen-Jun Ding, You-Cai Xu, Yu-Ting Wu, Shuang-Wei Zhang, Rui-Xue Chen, Jun Kan, En-Xin Zhang, Bin Liu, Jing-Zhi Zhang
Summary: This study demonstrated that Dauricine (Dau) inhibits proliferation and promotes cell death in melanoma cells by inhibiting the Src/STAT3 pathways. Molecular docking, dynamics simulations, and surface plasmon resonance imaging further supported the strong binding affinity of Dau to Src, and its effectiveness in suppressing melanoma growth in vivo.
PHYTOTHERAPY RESEARCH
(2021)
Article
Hematology
Derek B. Oien, Samanta Sharma, Maureen M. Hattersley, Michelle DuPont, Steven W. Criscione, Laura Prickett, Anne U. Goeppert, Lisa Drew, Yi Yao, Jingwen Zhang, Ho Man Chan
Summary: The combination of AZD5153 and acalabrutinib enhances the efficacy of treatment for ABC-DLBCL by regulating PAX5 and BCR mechanisms, inhibiting cell growth and metastasis.
Article
Cell Biology
Xuhui Fan, Haotian Fu, Ni Xie, Hangcheng Guo, Tiantian Fu, Yunfeng Shan
Summary: The study revealed that panaxadiol significantly inhibited proliferation and induced apoptosis in human pancreatic cancer cells, as well as suppressed the migration of pancreatic cancer cells, suggesting its potential as an anti-tumor agent for pancreatic cancer treatment.
Editorial Material
Cell Biology
Mirjam M. Zegers, Peter Friedl
DEVELOPMENTAL CELL
(2015)
Review
Cell Biology
Anna Haeger, Katarina Wolf, Mirjam M. Zegers, Peter Friedl
TRENDS IN CELL BIOLOGY
(2015)
Article
Cell Biology
Jan-Hendrik Venhuizen, Mirjam M. Zegers
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2017)
Article
Cell Biology
Dennis J. Eastburn, Mirjam M. Zegers, Keith E. Mostov
JOURNAL OF CELL SCIENCE
(2012)
Correction
Cell Biology
Peter Friedl, Katarina Wolf, Mirjam M. Zegers
NATURE CELL BIOLOGY
(2014)
Editorial Material
Cell Biology
Peter Friedl, Katarina Wolf, Mirjam M. Zegers
NATURE CELL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Orlando Deleon, Jason M. Puglise, Fengming Liu, Jos Smits, Martin B. ter Beest, Mirjam M. Zegers
Review
Cell Biology
Mirjam M. Zegers
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Jan-Hendrik Venhuizen, Sebastian Sommer, Paul N. Spann, Peter Friedl, Mirjam M. Zegers
SCIENTIFIC REPORTS
(2019)
Review
Oncology
Jan-Hendrik Venhuizen, Femke J. C. Jacobs, Paul N. Span, Mirjam M. Zegers
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Education & Educational Research
Wiljan J. A. J. Hendriks, Nicole Bakker, Helma Pluk, Arjan de Brouwer, Be Wieringa, Alessandra Cambi, Mirjam Zegers, Derick G. Wansink, Ron Leunissen, Peter H. M. Klaren
BMC MEDICAL EDUCATION
(2019)
Review
Biochemistry & Molecular Biology
Miriam van der Maten, Casper Reijnen, Johanna M. A. Pijnenborg, Mirjam M. Zegers
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Oncology
Jan-Hendrik Venhuizen, Paul N. Span, Koen van den Dries, Sebastian Sommer, Peter Friedl, Mirjam M. Zegers
Article
Chemistry, Multidisciplinary
Ying Zhang, Chunling Tang, Paul N. Span, Alan E. Rowan, Tilly W. Aalders, Jack A. Schalken, Gosse J. Adema, Paul H. J. Kouwer, Mirjam M. P. Zegers, Marleen Ansems
Article
Chemistry, Multidisciplinary
Ying Zhang, Mirjam M. P. Zegers, Anika Nagelkerke, Alan E. Rowan, Paul N. Span, Paul H. J. Kouwer
Summary: Morphogenesis is a tightly-regulated developmental process by which tissues acquire critical morphology for their function. Novel hybrid matrices of Matrigel and synthetic oligo(ethylene glycol)-grafted polyisocyanides (PICs) hydrogels are used to create a highly tailorable environment, leading to a broad range of morphologies induced in MDCK cells by controlling stiffness and cell-matrix interactions. The hybrid hydrogels induce a range of morphological changes, including a shift from round hollow cysts to 2D monolayers and the formation of tubular structures in 3D cultures.