Review
Nutrition & Dietetics
Sascha Venturelli, Christian Leischner, Thomas Helling, Markus Burkard, Luigi Marongiu
Summary: The imbalance of micronutrients in the Western-style diet may lead to cellular damage and increase the risk of cancer, highlighting the need for more data to assess the effectiveness of vitamins as biomarkers in cancer.
Review
Biochemistry & Molecular Biology
Janos Hunyady
Summary: Vitamin C has both antioxidant and pro-oxidant properties, and it exhibits cytotoxic effects on cancer cells. However, the therapeutic effect of high-dose intravenous vitamin C treatment in cancer patients is currently ambiguous based on clinical evidence. Further research is needed to evaluate its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christophe Glorieux, Pedro Buc Calderon
Summary: The significance of vitamin C in cancer treatment has a debated history, but recent studies have shown its potential in selectively targeting mutant cancer cells. The benefits of antioxidants remain inconclusive, yet the low toxicity of vitamin C presents a safe option in cancer treatment. Further research into the interactions between vitamin C and reactive species could lead to optimal combinations with standard treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Cesar I. Fernandez-Lazaro, Miguel Angel Martinez-Gonzalez, Inmaculada Aguilera-Buenosvinos, Alfredo Gea, Miguel Ruiz-Canela, Andrea Romanos-Nanclares, Estefania Toledo
Summary: The study found no significant protective associations between dietary vitamins A, C, and E, selenium, or zinc and breast cancer risk.
Review
Biochemistry & Molecular Biology
Marcelo Villagran, Jorge Ferreira, Miquel Martorell, Lorena Mardones
Summary: Vitamin C plays a significant role in cancer prevention and treatment, with studies showing its potential benefits in preventing pulmonary and breast cancer, as well as its synergistic effects with pancreatic cancer drugs. However, a Mendelian randomized study did not find an association between vitamin C and cancer prevention. Ongoing research is needed to further explore the therapeutic role of vitamin C in cancer through new phase II and III clinical trials.
Article
Nutrition & Dietetics
Huiyeon Song, Ansun Jeong, Thi Xuan Mai Tran, Jiseon Lee, Mikyung Kim, Boyoung Park
Summary: This study investigated the association between micronutrient intake and breast cancer risk in South Korean women. The study found that overall, there was no significant association between micronutrients and breast cancer risk. However, in obese women, exceeding the recommended intake levels of vitamin C and vitamin B6 was associated with a lower risk of breast cancer.
Review
Nutrition & Dietetics
Bianca J. Collins, Mitali S. Mukherjee, Michelle D. Miller, Christopher L. Delaney
Summary: Vitamin C supplementation can increase vitamin C levels in populations with or without cardiovascular disease, but further research is needed for different population groups with varying baseline vitamin C levels to update supplementation guidelines.
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Genetics & Heredity
Hanxiao Chen, Ze Du, Yaoyao Zhang, Mengling Li, Rui Gao, Lang Qin, Hongjing Wang
Summary: Current studies indicate that there is no causal association between vitamin C and the risk of cancer. Further research is needed to discover the potential protective and therapeutic effects of vitamin C on cancer and its underlying mechanisms.
FRONTIERS IN GENETICS
(2022)
Article
Nutrition & Dietetics
Anitra C. Carr, Gladys Block, Jens Lykkesfeldt
Summary: This study suggests that individuals with higher body weights may need to consume additional vitamin C to reach comparable levels as lighter individuals, potentially underscoring the inadequacy of current recommendations for higher body weight individuals.
Review
Oncology
Yool Lee
Summary: This review focuses on the potential therapeutic use of vitamin C (VC) in cancer treatment, particularly its selective targeting and reduction of cancer stem cells (CSCs). It provides important insights for improving anti-cancer therapeutic strategies.
Article
Immunology
Jing Yuan, Yu-hong Zhang, Xin Hua, Hui-qi Hong, Wei Shi, Kun-xiang Liu, Ze-xian Liu, Peng Huang
Summary: Recent studies have shown that vitamin C can reduce the incidence and mortality of cancer, but the mechanisms behind this effect are still unclear. This study conducted a comprehensive analysis and validation to investigate the prognostic value of vitamin C and its association with immune characteristics in various cancers.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Anitra C. C. Carr, Masuma Zawari
Summary: The global healthcare burden of an aging population is increasing, with a significant portion of diseases attributed to older individuals. Micronutrient deficiencies, including vitamin C, are common among older people and can contribute to chronic illnesses. While there is limited evidence suggesting that healthy aging is associated with lower vitamin C levels or increased requirements, institutionalized elderly individuals tend to have lower vitamin C status and enhanced requirements due to poor intake and chronic illness. Appropriate nutritional interventions are necessary to support healthy aging in this vulnerable population.
Article
Biochemistry & Molecular Biology
Muhammad Furqan, Taher Abu-Hejleh, Laura M. Stephens, Stacey M. Hartwig, Sarah L. Mott, Casey F. Pulliam, Michael Petronek, John B. Henrich, Melissa A. Fath, Jon C. Houtman, Steven M. Varga, Kellie L. Bodeker, Aaron D. Bossler, Andrew M. Bellizzi, Jun Zhang, Varun Monga, Hariharasudan Mani, Marina Ivanovic, Brian J. Smith, Margaret M. Byrne, William Zeitler, Brett A. Wagner, Garry R. Buettner, Joseph J. Cullen, John M. Buatti, Douglas R. Spitz, Bryan G. Allen
Summary: The combination of pharmacological ascorbate and chemotherapy improves tumor response in advanced stage non-small cell lung cancer (NSCLC) patients and appears to alter the host immune response. Further investigation is needed to explore the potential of this treatment as an adjuvant to immunotherapy.
Article
Nutrition & Dietetics
Javier Moreno-Montanes, Elsa Gandara, Laura Moreno-Galarraga, Maria S. Hershey, Jose Francisco Lopez-Gil, Stefanos Kales, Maira Bes-Rastrollo, Miguel Angel Martinez-Gonzalez, Alejandro Fernandez-Montero
Summary: Previous studies have shown contradictory results regarding the association between antioxidant consumption and glaucoma. This study found that while individual intake of vitamins A, C, and E did not demonstrate a significant protective effect, their combined consumption was associated with a reduced risk of glaucoma.