Article
Multidisciplinary Sciences
Rashad Haidar, Frank Henkler, Josephine Kugler, Aline Rosin, Doris Genkinger, Peter Laux, Andreas Luch
Summary: This study found that the stable compartmentalization of activated AHR in the nucleus does not depend on interactions with DNA or ARNT, and ARNT does not play a role in the intracellular trafficking of AHR.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Junwon Kim, Mark D. Rose
Summary: In Saccharomyces cerevisiae, the p21-activated kinase Cla4p regulates polarized morphogenesis and cytokinesis. Cla4p kinase activity is down-regulated during mating, and this is achieved through phosphorylation of Cla4p at multiple sites, including Cla4p-S186, which reduces its kinase activity. Fus3p counteracts Cla4p kinase activity during mating by phosphorylating Fus2p at different sites to promote nuclear export and block import.
Article
Cell Biology
Yuval Yung, Zhong Yao, Tamar Hanoch, Rony Seger
Summary: This study identified a new splice variant of ERK, termed ERK1b, with a molecular weight of 46kDa. ERK1b was found to be the major isoform responding to exogenous stimulation in Ras-transformed cells, possibly due to its differential regulation by MAPK/ERK kinase and phosphatases.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Shiho Hisaoka, Jin Osawa, Riku Kobashi, Atsuhiko Ishida, Isamu Kameshita, Noriyuki Sueyoshi
Summary: Research has shown that BMP2-inducible kinase (BMP2K) forms liquid-liquid phase separated droplets in the cytoplasm, regulated by a glutamine-rich area and hyperosmolarity. The cytoplasmic localization of BMP2K is managed through the inhibition of nuclear localization signal (NLS) function via phosphorylation of Ser-1010 and the antagonism of the NLS by a newly discovered cytoplasmic localization region. These findings provide a biochemical foundation for the advancement of BMP2K-related cell biology, structural biology, and pathophysiology.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Plant Sciences
Hongbo Li, Juan Wei, Yanglan Liao, Xiaoling Cheng, Shuhong Yang, Xiaohong Zhuang, Zhonghui Zhang, Wenjin Shen, Caiji Gao
Summary: This study reveals a previously unidentified function of plant-specific casein kinase I members in attenuating ABA signaling by regulating the phosphorylation and nuclear accumulation of FREE1.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Sangho Lee, Han-Teo Lee, Young Ah Kim, Il-Hwan Lee, Seong-Jun Kang, Kyeongpyo Sim, Chung-Gyu Park, Kyungho Choi, Hong-Duk Youn
Summary: A peptide derived from CABIN1 binds strongly to the cellular enzyme calcineurin and inhibits its activity, providing a potential therapeutic option for diseases related to the calcineurin-NFAT pathway.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Cell Biology
Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao, Haihua Ruan
Summary: This article summarizes the types of nuclear localization signals, focuses on recently reported proteins containing such signals, and briefly outlines mechanisms for nuclear entry that do not rely on nuclear localization signals.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Sheng Yan, Bin Peng, Shifeng Kan, Guangcan Shao, Zhikai Xiahou, Xiangyan Tang, Yong-Xiang Chen, Meng-Qiu Dong, Xiao Liu, Xingzhi Xu, Jing Li
Summary: This article investigates the impact of O-GlcNAc transferase (OGT) on PLK1, and finds that OGT can modify PLK1 through O-GlcNAcylation. Further research reveals that the T291A and T291N mutations increase the stability of PLK1 and lead to chromosome segregation defects and uterine carcinoma. The findings suggest that OGT exerts its mitotic function partially through O-GlcNAcylation of PLK1, which may contribute to tumorigenesis by elevating O-GlcNAc levels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Virology
Luis Adrian De Jesus-Gonzalez, Selvin Noe Palacios-Rapalo, Jose Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Carlos Noe Farfan-Morales, Carlos Daniel Cordero-Rivera, Bulmaro Cisneros, Ana Lorena Gutierrez-Escolano, Rosa Maria del Angel
Summary: Recent evidence suggests that nuclear elements play a role in the replication of Flaviviruses, with certain viral proteins being imported into the nucleus. Furthermore, nuclear localization of these proteins has been observed in infected cells. The presence of ZIKV NS3 in the nucleus has been investigated, showing that NS3 is imported into the nucleus via the importin pathway and exported back to the cytoplasm.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyan Li, Zhengming Wu, Jing He, Yiting Jin, Chengyu Chu, Yun Cao, Fei Gu, Hongying Wang, Chenjian Hou, Xiuping Liu, Qiang Zou
Summary: The incidence of thyroid cancer is increasing globally, with poor prognosis associated with distant metastases. OGT and YAP play critical roles in papillary thyroid cancer, suggesting potential for targeted therapies.
Article
Biochemistry & Molecular Biology
Ekaterina M. Sogorina, Ekaterina R. Kim, Alexey V. Sorokin, Dmitry N. Lyabin, Lev P. Ovchinnikov, Daria A. Mordovkina, Irina A. Eliseeva
Summary: YB-1 is a multifunctional protein involved in cell proliferation, differentiation, and migration that binds to DNA and RNA. In tumors, YB-1 nuclear localization is associated with high aggressiveness, multidrug resistance, and poor prognosis. Posttranslational modifications are known to regulate YB-1 nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Min Chen, Xue Yang, Haiyang Liu, Jun Wan
Summary: In this study, a functional bipartite nuclear localization signal (bNLS) in the ANKRD11 gene was identified. It was found that this bNLS is responsible for the nuclear import of ANKRD11 and certain clinical variants of this signal may be related to disease development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Virology
Anna Nakanishi, Hiroki Okumura, Tadahiro Hashita, Aya Yamashita, Yuka Nishimura, Chihiro Watanabe, Sakina Kamimura, Sanae Hayashi, Shuko Murakami, Kyoko Ito, Takahiro Iwao, Akari Ikeda, Tomoyasu Hirose, Toshiaki Sunazuka, Yasuhito Tanaka, Tamihide Matsunaga
Summary: This study reveals that ivermectin can suppress HBV production by inhibiting the nuclear import of HBV through KPNA2. It demonstrates the potential of ivermectin as a novel treatment for hepatitis B.
Article
Biochemistry & Molecular Biology
Susana Mendez-Gomez, Heidi Espadas-Alvarez, Ivette Ramirez-Rodriguez, Lilianha Dominguez-Malfavon, Refugio Garcia-Villegas
Summary: The localization of TRPV4 ion channel between the nucleus and plasma membrane is crucial for its cellular functions, and mutations may lead to TRPV4 channelopathies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)