Article
Biochemistry & Molecular Biology
Ying Lu, Wen-Bing Ma, Guang-Ming Ren, Xian Liu, Ya-Ting Li, Ting Wang, Yi-Qun Zhan, Shen -Si Xiang, Miao Yu, Chang-Yan Li, Xiao-Ming Yang, Rong-Hua Yin
Summary: In this study, researchers identified VPS37C as a crucial regulator of EKLF stability, enhancing EKLF protein stability and transcriptional activity, and promoting erythroid differentiation. This finding contributes to a better understanding of the molecular mechanisms underlying erythroid differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Yingying Zhang, Lifang Shi, Ke Yang, Xuehui Liu, Xiang Lv
Summary: This study revealed the important role of transglutaminase 2 (TGM2) in fetal liver erythroid differentiation, which is regulated by its cross-linking enzyme activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Hematology
Zachary C. Murphy, Kristin Murphy, Jacquelyn Myers, Michael Getman, Tyler Couch, Vincent P. Schulz, Kimberly Lezon-Geyda, Cal Palumbo, Hongxia Yan, Narla Mohandas, Patrick G. Gallagher, Laurie A. Steiner
Summary: The terminal maturation of human erythroblasts involves significant changes in histone marks associated with active transcription elongation, rather than heterochromatin accumulation. Regulation of RNA polymerase II activity and gene expression at the transcriptional level play a critical role in controlling the maturation process of erythroblasts.
Article
Multidisciplinary Sciences
Myriam Cuadrado, Javier Garzon, Sergio Moreno, Irene Garcia-Higuera
Summary: The APC/C-Cdh1 complex plays an important role in the G1 phase of the cell cycle and cell differentiation. This study found that APC/C-Cdh1 activity is crucial for terminal erythroid differentiation during fetal development and postnatal period. Deletion of Cdh1 leads to mild but persistent anemia and affects both steady-state and stress erythropoiesis. Furthermore, Cdh1 loss results in DNA damage accumulation and delayed cell cycle progression, potentially due to replicative stress. These alterations restrain full maturation of erythroblasts and reduce the output of functional erythrocytes, leading to anemia.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ryuta Maekawa, Hideki Muto, Minoru Hatayama, Jun Aruga
Summary: This study showed that Lrfn2-deficient mice exhibit abnormalities in the hematopoietic system, including normocytic erythrocythemia and reduced platelet volume. The results suggest that Lrfn2 may regulate erythropoiesis through its regulatory activity on NMDA receptors.
Review
Medicine, Research & Experimental
Zexi Liao, Jiaxin Li, Jingjing Wu, Jing Liu, Shuming Sun
Summary: Acute erythroid leukemia (AEL) is a subtype of acute myeloid leukemia (AML) characterized by the accumulation of maturation-arrested erythroblasts. AEL progresses faster than AML and has a worse prognosis to available therapy. The classification of AEL is still being updated and its pathophysiology is under research.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Shoupei Liu, Jue Wang, Sen Chen, Zonglin Han, Haibin Wu, Honglin Chen, Yuyou Duan
Summary: In this study, the enhancement of the liver transcription factor C/EBP beta was found to significantly promote the expression of hepatic genes and reinforce the proliferation capacity of hepatocytes. It was demonstrated that C/EBP beta directly bound to the promoter regions of proliferative genes and regulated cell proliferation by coupling with E2F2. This study provides a novel approach to generate proliferative hepatocytes for clinical and research applications.
Article
Hematology
Raymond T. Doty, Xing Fan, David J. Young, Jialiu Liang, Komudi Singh, Zahra Pakbaz, Ronan Desmond, Sara K. Young-Baird, Settara C. Chandrasekharappa, Frank X. Donovan, Susan R. Phelps, Thomas Winkler, Cynthia E. Dunbar, Janis L. Abkowitz
Summary: This study follows a patient with Diamond-Blackfan anemia (DBA) and discovers that eltrombopag (EPAG) not only improves her anemia but also maintains the mosaicism. Further experiments using DBA mice and mice lacking a heme export protein support the hypothesis that excess heme in ribosomal protein-deficient erythroid cells inhibits the growth of adjacent normal precursors. The findings have implications for DBA gene therapy and provide insights into anemia in del(5q) myelodysplastic syndrome patients.
Article
Biochemistry & Molecular Biology
RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth
Summary: Cells respond to reduced oxygen availability primarily through activation of the HIF pathway, which upregulates genes for cell survival. This study investigated the effects of DMOG on PC12 cells cultured in varying oxygen levels, finding that DMOG stabilises HIF and affects mitochondrial activity and cell behaviour, but does not accurately replicate the reduced oxygen environment.
Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Xi Tan, Lingfeng Yang, Joanne E. Brady, Mei Yang, Puja Banka, Dominik Lautsch
Summary: The study found that NT-proBNP testing was not frequently performed in patients with heart failure with reduced ejection fraction (HFrEF) in US clinical practice, and the concentrations varied across different data sources and subgroups within HFrEF.
Article
Hematology
Mark C. Wilkes, Vanessa Scanlon, Aya Shibuya, Alma-Martina Cepika, Ascia Eskin, Zugen Chen, Anupama Narla, Bert Glader, Maria Grazia Roncarolo, Stanley F. Nelson, Kathleen M. Sakamoto
Summary: Diamond-Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome associated with anemia, congenital anomalies, and cancer predisposition. A study found that ribosomal insufficiency leads to a block and delay in early erythropoiesis, affecting multiple stages of erythroid differentiation.
EXPERIMENTAL HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Julia Herrero Huertas, Marta Garcia Clemente, Beatriz Diaz Molina, Jose Luis Lambert Rodriguez, Marta Iscar Urrutia
Summary: This study analyzed the differences between treadmill and cycle-ergometer exercises in heart failure patients and found that treadmill exercise resulted in higher peak VO2 and greater ventilatory response compared to cycle-ergometer exercise. These differences may impact prognostic evaluations and treatment options.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Carly Adamson, Kieran F. Docherty, Rudolf A. de Boer, Mark C. Petrie, Silvio E. Inzucchi, Mikhail N. Kosiborod, Anna Maria Langkilde, Daniel Lindholm, Felipe A. Martinez, Olof Bengtsson, Morten Schou, Eileen O'Meara, Piotr Ponikowski, Marc S. Sabatine, Mikaela Sjostrand, Scott D. Solomon, Pardeep S. Jhund, John J. V. McMurray, Lars Kober
Summary: The study showed that in HFrEF patients, dapagliflozin significantly reduced NT-proBNP levels after 8 months of treatment compared to placebo. Additionally, dapagliflozin reduced the risk of worsening HF and death, and improved symptoms across the spectrum of baseline NT-proBNP levels included in DAPA-HF.
CIRCULATION-HEART FAILURE
(2021)
Article
Hematology
Raymond T. Doty, Xiaowei Yan, Changting Meng, Christopher Lausted, Qiang Tian, Janis L. Abkowitz
Summary: This study fully characterized Rpl11 haploinsufficient mice as a model of DBA, showing similarities to the macrocytic anemia seen in DBA patients. The researchers found that heme excess and toxicity were the primary drivers of this anemia, and identified pathways associated with erythroid differentiation impairment. These findings suggest that Rpl11 haploinsufficient mice can be used as a valuable model to study DBA pathogenesis and test novel therapies.
EXPERIMENTAL HEMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, John J. V. McMurray, Brian L. Claggett, Zi Michael Miao, Kirkwood F. Adams, Alexandra Arias-Mendoza, John G. F. Cleland, Rafael Diaz, Luis E. Echeverria Correa, G. Michael Felker, Candida Fonseca, Jing Li, Marco Metra, Karen Sliwa-Hahnle, Scott D. Solomon, Hans J. Vandekerckhove, Dragos Vinereanu, Adriaan A. Voors, Stephen B. Heitner, Stuart Kupfer, Fady I. Malik, Lisa Meng, John R. Teerlink
Summary: This study aimed to examine the effect of omecamtiv mecarbil in heart failure patients according to the NT-proBNP levels. The results showed that omecamtiv mecarbil had a greater benefit in patients with higher baseline NT-proBNP levels, especially those without atrial fibrillation/flutter.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)