Article
Multidisciplinary Sciences
Yu-Zu Guo, Yi Zhang, Qing Wang, Jun Yu, Qiu-Hong Wan, Jun Huang, Sheng-Guo Fang
Summary: Alligators are suitable for studying anti-aging molecular mechanisms because they have low adult mortality rates and no significant telomere shortening. Selection analyses have shown that certain genes in alligators have undergone positive selection, and ALT-related genes are expressed at higher levels, which may contribute to anti-aging strategies.
Review
Cell Biology
Alex Penev, Marta Markiewicz-Potoczny, Agnel Seir, Eros Lazzerini Denchi
Summary: This review discusses the differences in telomere protection in embryonic stem cells and somatic cells, and summarizes the findings on telomerase regulation and pluripotency function.
TRENDS IN CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Omkar Suhas Vinchure, Kurt Whittemore, Deependra Kushwah, Maria A. Blasco, Ritu Kulshreshtha
Summary: miR-490 targets multiple genes to regulate telomere maintenance in GBM, exerting tumor suppressive effects, impacting stemness and senescence, activating DNA damage response, and potentially holding therapeutic significance in GBM treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biology
Anna K. Uryga, Mandy O. J. Grootaert, Abel M. Garrido, Sebnem Oc, Kirsty Foote, Joel Chappell, Alison Finigan, Francesca Rossiello, Fabrizio D'Adda di Fagagna, Dimitra Aravani, Helle F. Jorgensen, Martin R. Bennett
Summary: Accumulation of vascular smooth muscle cells (VSMCs) is a hallmark of multiple vascular pathologies. The study suggests that persistent telomere damage in VSMCs inducing cell senescence has a major role in driving persistent inflammation in vascular disease. The findings indicate that telomere injury and DNA damage can be primary causes of premature senescence and persistent inflammation in VSMCs.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Freddy Khayat, Elda Cannavo, Majedh Alshmery, William R. Foster, Charly Chahwan, Martino Maddalena, Christopher Smith, Anthony W. Oliver, Adam T. Watson, Antony M. Carr, Petr Cejka, Alessandro Bianchi
Summary: In budding yeast, the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus. This indicates a mechanism to suppress the DNA damage response at chromosome ends.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Hiroshi Ebata, Tze Mun Loo, Akiko Takahashi
Summary: This review summarizes the unique characteristics of cancer cells, such as high proliferation and aberrant DNA damage response, and the role of telomerase and ALT in cancer regulation. It focuses on their noncanonical functions beyond telomere maintenance, as well as intercellular communication in the tumor microenvironment (TME) through the cGAS-STING pathway. Understanding the functional connection between telomere-related molecules and TME regulation is crucial for developing cancer therapeutics targeting specific pathways.
Review
Biochemistry & Molecular Biology
Elias A. Tannous, Peter M. Burgers
Summary: DNA replication is a precise process, but cells face obstacles such as replication blocks and lack of precursors that can lead to chromosome instability and mutations. The PIKK family plays a crucial role in the cell's response mechanism, with recent studies showing significant progress in understanding the structure and activity of human ATR and ATM.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lara Lee, Ana Belen Perez Olivaz, Elena Martinez-Balsalobre, Dmitri Churikov, Joshua Peter, Dalicya Rahmouni, Gilles Audoly, Violette Azzoni, Stephane Audebert, Luc Camoin, Victoriano Mulero, Maria L. Cayuela, Yogesh Kulathu, Vincent Geli, Christophe Lachaud
Summary: UFM1 is involved in neural and erythroid development, deficiency of which leads to telomere shortening, developmental delay, impaired hematopoiesis, and premature aging. MRE11-UFMylation plays a key role in regulating telomere length by recruiting PP1-alpha and affecting the phosphorylation status of NBS1, thereby impacting MRN recruitment to telomeres.
Article
Biochemistry & Molecular Biology
Sonia Paget, Marion Dubuissez, Adeline Page, Vanessa Dehennaut, Ingrid Loison, Nathalie Spruyt, Dominique Leprince
Summary: HIC1 is a tumor suppressor gene encoding a transcriptional repressor that plays a role in the DNA-damage response. Specific posttranslational modifications, such as phosphorylation and acetylation, are crucial for the function of HIC1 and its activity in DNA repair. These modifications are essential for HIC1-mediated cellular response to repairable DNA double strand breaks.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Fei Li, Yizhe Wang, Inah Hwang, Ja-Young Jang, Libo Xu, Zhong Deng, Eun Young Yu, Yiming Cai, Caizhi Wu, Zhenbo Han, Yu-Han Huang, Xiangao Huang, Ling Zhang, Jun Yao, Neal F. Lue, Paul M. Lieberman, Haoqiang Ying, Jihye Paik, Hongwu Zheng
Summary: Through genetic screens, researchers identify histone lysine demethylase KDM2A as a molecular vulnerability in ALT-dependent cancer cells and demonstrate its role in the resolution of ALT-specific telomere clusters via recruitment of SENP6.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Carlo Rinaldi, Paolo Pizzul, Erika Casari, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese
Summary: DSBs can be repaired by HR or NHEJ. Ku helps keep the DNA ends tethered to each other, while Tel1 kinase antagonizes Ku's function by promoting nucleosome removal and Ku sliding. This regulation is important for controlling DSB repair mode.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biology
Maria Sol Jacome Burbano, Jerome D. Robin, Serge Bauwens, Marjorie Martin, Emma Donati, Lucia Martinez, Peipei Lin, Sabrina Sacconi, Frederique Magdinier, Eric Gilson
Summary: TRF2 and FOXO3a play important roles in regulating skeletal muscle aging. Loss of TRF2 leads to oxidative stress, which triggers FOXO3a binding to telomeres and protects against ATM activation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemical Research Methods
Martin Lycka, Vratislav Peska, Martin Demko, Ioannis Spyroglou, Agata Kilar, Jiri Fajkus, Miloslava Fojtova
Summary: This study introduces a new online toolset called WALTER for the rapid, reproducible, and user-friendly analysis of telomere length data and statistical evaluation, representing a major upgrade in TRF scan image processing.
BMC BIOINFORMATICS
(2021)
Article
Multidisciplinary Sciences
Adeline Augereau, Marco Mariotti, Melanie Pousse, Doria Filipponi, Frederick Libert, Benjamin Beck, Vera Gorbunova, Eric Gilson, Vadim N. Gladyshev
Summary: The study reveals that the naked mole rat TRF1 supports maximal glycolytic capacity under low oxygen, showing increased nuclear localization and association with telomeres, and protecting them from replicative stress. The evolutionary gain of metabolic function in naked mole rat TRF1 is attributed to specific amino acid changes in the protein's homodimerization domain, while it also accelerates telomere shortening. This evolutionary strategy highlights an adaptation of telomere biology for metabolic control in extreme environments.
Article
Medicine, General & Internal
Saadiya Zia, Netasha Khan, Komal Tehreem, Nazia Rehman, Rokayya Sami, Roua S. Baty, Faris J. Tayeb, Majed N. Almashjary, Nouf H. Alsubhi, Ghadeer Alrefaei, Ramla Shahid
Summary: This study found that the expression levels of the CTC1 gene were significantly upregulated in pediatric and adult ALL patients, showing a significant association with ALL occurrence. This suggests that CTC1 has the potential to be used as a risk biomarker for the diagnosis of ALL in both pediatric and adult populations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Carol M. Anderson, Ashwini Oke, Phoebe Yam, Tangna Zhuge, Jennifer C. Fung
Article
Cell Biology
Carol M. Anderson, Elizabeth H. Blackburn
Article
Cell Biology
Carol M. Anderson, Dmitry Korkin, Dana L. Smith, Svetlana Makovets, Jeffrey J. Seidel, Andrej Sali, Elizabeth H. Blackburn
GENES & DEVELOPMENT
(2008)
Article
Multidisciplinary Sciences
Carol M. Anderson, Stacy Y. Chen, Michelle T. Dimon, Ashwini Oke, Joseph L. DeRisi, Jennifer C. Fung
Article
Genetics & Heredity
Ashwini Oke, Carol M. Anderson, Phoebe Yam, Jennifer C. Fung
Article
Biochemistry & Molecular Biology
MM Liu, C Albanese, CM Anderson, K Hilty, P Webb, RM Uht, RH Price, RG Pestell, PJ Kushner
JOURNAL OF BIOLOGICAL CHEMISTRY
(2002)
Article
Endocrinology & Metabolism
P Webb, CM Anderson, C Valentine, P Nguyen, A Marimuthu, BL West, JD Baxter, PJ Kushner
MOLECULAR ENDOCRINOLOGY
(2000)