期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 393, 期 1-2, 页码 191-197出版社
SPRINGER
DOI: 10.1007/s11010-014-2060-0
关键词
Free fatty acid; Palmitoylcarnitine; Lysophosphatidylcholine; Ventricular arrhythmia
类别
资金
- AFA insurance
- Swedish Heart and Lung Foundation
- Swedish Scientific Research Council
- University of Gothenburg, Sweden
Arrhythmias have been treated for a long time with drugs that mainly target the ionic pumps and channels. These anti-arrhythmic regimens per se introduce new arrhythmias, which can be detrimental to patients. Advances in development of novel pharmacology without introduction of iatrogenic arrhythmias are thus favorable for an effective treatment of arrhythmias. Electrophysiological stability of the heart has been shown to be closely associated with cardiac metabolism. The present effective anti-arrhythmic drugs such as beta-blockers and amiodarone have profound beneficial effects in regulating myocardial metabolism. Aiming at decreasing production of toxic metabolites or preventing accumulation of arrhythmogenic lipids perhaps is a good strategy to effectively control arrhythmias. Therefore, a better understanding of the pro-arrhythmic profiles of cardiac metabolites helps to explore a new generation of metabolically oriented anti-arrhythmic medications. In this review, we present several lipid metabolites and summarize their arrhythmogenic characteristics.
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