Article
Cell Biology
Bo Xiao, Liyan Liu, Zhuoyuan Chen, Aoyu Li, Yu Xia, Pingxiao Wang, Cheng Xiang, Yi Zeng, Hui Li
Summary: This study identified a novel prognostic marker based on stem cell-related genes for osteosarcoma patients, independent of other clinical traits. The marker was validated to be significant in predicting survival rate and providing potential therapeutic targets. The research suggests that the expression level of stem cell-related genes could serve as valuable prognostic markers and therapeutic targets for osteosarcoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chunlin Zhang, Jianping Hu, Yingying Jiang, Shuo Tan, Kunpeng Zhu, Chao Xue, Yunlu Dai, Feng Chen
Summary: This study demonstrates a novel biomineralization-inspired strategy for the synthesis of a fructose incorporated manganese phosphate (Fru-MnP) nanoplatform for targeted therapy, drug-free therapy, and MRI imaging of osteosarcoma. The Fru-MnP nanoplatform produces reactive oxygen species (ROS) through the Mn2+-driven Fenton reaction within osteosarcoma cells, leading to caspase-mediated apoptosis and efficient cancer cell killing. Additionally, it serves as an effective tumor-specific MRI contrast agent, allowing for MRI-monitored chemodynamic therapy.
Article
Orthopedics
Pei Zhang, Jiale Zhang, Huahong Quan, Jingcheng Wang, Yuan Liang
Summary: This study investigated the expression of miR-143 in osteosarcoma and its impact on tumor growth and invasion. The results showed that high levels of miR-143 were associated with reduced tumor volume, increased survival rate, and improvements in lung metastasis and tumor grade. miR-143 may have important value in the treatment and prognosis of osteosarcoma.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, General & Internal
Liping Zhuang, Zhiqiang Meng, Zongguo Yang
Summary: MRPL27, upregulated in tumor tissues of cholangiocarcinoma patients, contributes to unfavorable survival outcomes for these patients. Bioinformatic analysis further suggests its involvement in mitochondrial translation elongation, respiratory electron transport, ATP synthesis, and inner mitochondrial membrane organization.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Genetics & Heredity
Yuehui Du, Xiaohui Zeng, Weiwei Yu, Wei Xie
Summary: We constructed a prognostic signature based on six TMEM protein family genes and found that it can stratify osteosarcoma patients into high- and low-risk groups. Functional enrichment analysis revealed the association between immunity and the prognostic signature. Additionally, the high-risk group had lower proportions of M2 macrophages in the immune microenvironment and lower scores of neutrophils and Treg.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Di Zheng, Zhun Wei, Weichun Guo
Summary: By studying the expression of SLC family genes in osteosarcoma patients, we identified a novel gene signature that can predict the prognosis risk of patients. Furthermore, this signature is associated with immune status and immune cell infiltrations in the tumor microenvironment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Dong Wook Shin, Jong Ho Cho, Jung Eun Yoo, Juhee Cho, Dong Woog Yoon, Genehee Lee, Sumin Shin, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Zo, Young Mog Shim
Summary: Five-year conditional survival rates for NSCLC patients undergoing curative resection improved over time, but still showed significant risk after 5 years. Age and pathological stage remained significant predictors of conditional survival several years after surgery, while other factors such as sex, histology, smoking status, comorbidity, and lung function also influenced survival rates.
CANCER RESEARCH AND TREATMENT
(2021)
Review
Oncology
Shinji Tsukamoto, Andreas F. Mavrogenis, Lucia Angelelli, Alberto Righi, Giuseppe Filardo, Akira Kido, Kanya Honoki, Yuu Tanaka, Yasuhito Tanaka, Costantino Errani
Summary: The 5-year disease-free survival rate for patients with localized extraskeletal osteosarcoma (ESOS) who underwent surgery combined with (neo)adjuvant chemotherapy was slightly higher than those who underwent surgery alone. Therefore, routine adjuvant chemotherapy for localized ESOS should be avoided.
Article
Genetics & Heredity
Zhengqi Bao, Ruizhi Zhu, Huagang Fan, Yuchen Ye, Tian Li, Damin Chai
Summary: Overexpression of SPAG6 and low expression of NM23 are negatively related to pathological grade, metastasis, and Enneking stage and prognosis of osteosarcoma patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yanchuan Pu, Jin Wang, Jianshu Wang, Shizhong Wang
Summary: The utility of preoperative D-dimer and plasma fibrinogen levels in predicting the clinical value of osteosarcoma patients was evaluated. Elevated D-dimer levels were associated with aggressive clinicopathological features and poor survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Long-Qing Li, Liang-Hao Zhang, Yao-bo Yuan, Xin-Chang Lu, Yi Zhang, Yong-Kui Liu, Jia Wen, Manhas Abdul Khader, Tao Liu, Jia-Zhen Li, Yan Zhang
Summary: This study explores the value of genes related to osteosarcoma metabolism by constructing metabolic-related gene pairs (MRGP) signature, which can reliably predict overall survival, is associated with metastatic status, and can guide the application of immunotherapy for patients with osteosarcoma.
Article
Medicine, General & Internal
Anne Jacobsen, Mirianna Hobbs, Susanne Merkel, Anke Mittelstaedt, Franziska Czubayko, Christian Krautz, Georg F. Weber, Robert Gruetzmann, Maximilian Brunner
Summary: This study investigated the prognostic value of time from diagnosis to surgery in patients undergoing upfront surgery for primarily resectable pancreatic carcinoma. The results showed that a delay of surgery > 23 days after diagnosis does not affect overall or disease-free survival of patients with primary resectable PDAC. Age, lymph node metastasis, tumor differentiation, and resection status were identified as significant independent prognostic predictors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Deanna D. Dailey, Ann M. Hess, Gerrit J. Bouma, Dawn L. Duval
Summary: miRNAs play a role in post-transcriptional gene regulation and can serve as prognostic markers in canine osteosarcoma. Dysregulation of miRNA expression is associated with prognosis in aggressive tumors, suggesting a potential link between miRNA regulatory networks and metastatic phenotype in dogs with osteosarcoma.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Oncology
Jing Wang, Xiang-zhi Ni, Ming-lei Yang, Xing Huang, Shu-ming Hou, Cheng Peng, Jia-shi Cao, Tie-Long Liu
Summary: This study comprehensively analyzed the demographic features, clinicopathologic characteristics and prognosis factors of spinal osteosarcoma using the SEER database. The results showed that male gender, high tumor grade, regional and metastasis stage, as well as radiotherapy, were independent predictors of poor survival in spinal osteosarcoma patients. The clinical treatment of spinal osteosarcoma still faces serious challenges.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Yiming Zhang, Rong He, Xuan Lei, Lianghao Mao, Pan Jiang, Chenlie Ni, Zhengyu Yin, Xinyu Zhong, Chen Chen, Qiping Zheng, Dapeng Li
Summary: In this study, a prognostic model based on pyroptosis-related genes was constructed to predict the outcome of osteosarcoma patients. Key genes affecting the prognosis of osteosarcoma patients were identified, forming a signature that independently predicts survival and metastasis risk.
FRONTIERS IN GENETICS
(2021)