期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 352, 期 1-2, 页码 1-10出版社
SPRINGER
DOI: 10.1007/s11010-011-0733-5
关键词
M. tuberculosis; mce; Genomic organization; Phylogeny; Virulence
类别
资金
- National key infectious disease project [2008ZX10003-006, 2008ZX10003-001]
- national natural science foundation [81071316]
- southwest university [kb2009010, ky2009009]
- Fundamental Research Funds for the Central Universities [XDJK2009A003]
- Natural Science Foundation [2010BB5002]
Knowledge of virulence factors is important to understand the microbial pathogenesis and find better antibiotics. Mammalian cell entry (mce) is a crucial protein family for the virulence of Mycobacterium tuberculosis (M. tuberculosis). This review summarized the advances on mce genes. The genomic organization, characteristics of mce genes, phylogeny of this family, and their roles in M. tuberculosis virulence are emphasized in this review.
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