期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 359, 期 1-2, 页码 59-66出版社
SPRINGER
DOI: 10.1007/s11010-011-0999-7
关键词
UCH37; GRP78; Interaction; HCC
类别
资金
- Ministry of Education
- National Basic Research Program of China [2007CB936000]
- Major National Science and Technology Projects [2009ZX10004-301, 2008ZX10002-017]
- Shanghai Science and Technology Commission [10410709400, 10411950100]
- Shanghai Talent Development Fund [2009-035]
- National Nature Science Foundation of China [30872503, 81000968]
- China Postdoctoral Science Foundation [20100480542]
- Innovation Foundation for Graduates of Fudan University [EYE152048]
- National Clinical Key Special Subject of China
The ubiquitin C-terminal hydrolase (UCH) is a subfamily of deubiquitinating enzymes, which consists of four members: UCH-L1, UCH-L3, UCH37, and BRCA1-associated protein-1. Although there is growing evidence that UCH enzymes and human malignancies are closely correlated, there have been few studies on UCH37, especially on its interactions with other proteins. In the current study, a functional proteomic analysis was performed to screen UCH37-interacting proteins in hepatocellular carcinoma (HCC), and glucose-regulated protein 78 was identified as one interacting with UCH37, which was confirmed by co-immunoprecipitation and confocal laser scanning microscopy analysis, suggesting that their interaction could provide a new insight into the mechanism of HCC.
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