Article
Cardiac & Cardiovascular Systems
Jochen Dutzmann, Marco Haertle, Jan-Marcus Daniel, Frederik Kloss, Robert-Jonathan Musmann, Katrin Kalies, Kai Knopp, Claudia Pilowski, Mirja Sirisko, Jan-Thorben Sieweke, Johann Bauersachs, Daniel G. Sedding, Simona Gegel
Summary: Selective inhibition of BET proteins can reduce proliferation and migration of SMCs by regulating FOXO1 transcription factor, leading to cell cycle arrest and prevention of neointima formation. Inhibition of BET epigenetic reader proteins may represent a promising therapeutic strategy to prevent adverse vascular remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ning Yang, Bo Dong, Yanqiu Song, Yang Li, Lu Kou, Qin Qin
Summary: This research investigated the role of CLU in regulating VSMC proliferation and migration in vascular restenosis. The findings showed that CLU was highly expressed in vascular restenosis and over-expression of CLU promoted VSMC autophagy, thus attenuating intimal hyperplasia and vascular restenosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Biomedical
Dongxu Qiu, Yalan Deng, Yanbin Wen, Jun Yin, Jie Feng, Jiabing Huang, Mingyu Song, Gui Zhang, Changqing Chen, Jian Xia
Summary: This study demonstrated that corroded granules produced by iron stents inhibit vascular smooth muscle cell (VSMC) proliferation and reduce neointimal hyperplasia in an atherosclerotic artery stenosis model. The corroded granules were found to primarily consist of iron oxide. Furthermore, the inhibitory effect on VSMC proliferation was observed to be mediated by the activation of autophagy through the AMPK/mTOR signaling pathway. The safety of iron corroded granules was also confirmed in a rabbit model.
MATERIALS TODAY BIO
(2022)
Article
Hematology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs stimulate proliferation and migration of SMCs and increase their neointimal accumulation following vascular injury. Furthermore, EPCs context-dependently modify the SMC phenotype with protection from the transformative effect of cholesterol when a direct cell-cell contact is established.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jingying Liu, Xingbo Long, Hexin Li, Qiuxia Yan, Lu Wang, Ziyu Qin, Hong Zhang
Summary: This study reveals that C1QTNF4 is involved in the migration and proliferation of vascular smooth muscle cells. It inhibits abnormal neointimal formation by downregulating the FAK/PI3K/AKT pathway, thus protecting blood vessels. These findings provide new insights and potential treatments for vascular stenosis diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Summary: The study found that celastrol effectively inhibited intimal hyperplasia and hyperproliferation of VSMCs by inducing autophagy, suggesting it may be a novel drug with great potential to prevent restenosis. The mechanism behind this effect involves lysosomal degradation of c-MYC and the Wnt5a/PKC/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Junchul Shin, Svyatoslav Tkachenko, Delphine Gomez, Rupande Tripathi, Gary K. Owens, Olga A. Cherepanova
Summary: OCT4 is quickly activated in SMC after acute vascular injury, inhibiting SMC hyperproliferation and potentially preventing excessive neointima formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Physiology
Sebastien Deglise, Clemence Bechelli, Florent Allagnat
Summary: Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.
Article
Endocrinology & Metabolism
Y. Peng, P. Cai, S. F. Zou, M. Jia, W. T. Zhong, Y. Wang, X. K. Wang
Summary: The study revealed that high doses of insulin promoted VSMCs proliferation by downregulating AP-1, leading to an increase in cells in the S phase. AP-1 was found to bind to the SM-alpha gene promoter to upregulate SM-alpha gene expression. Overexpression of SM-alpha suppressed VSMCs proliferation, while knockdown of SM-alpha promoted it.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Biochemistry & Molecular Biology
Reka Bogati, Eva Katona, Amir H. Shemirani, Eniko Balogh, Helga Bardos, Viktoria Jeney, Laszlo Muszbek
Summary: FXIIIa promotes cell proliferation and collagen secretion in human aortic smooth muscle cells (HAoSMCs), while reducing the concentration of thrombospondin-1 (TSP-1) in the culture medium. These effects may impact the development of atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Article
Cardiac & Cardiovascular Systems
Jeremy Lagrange, Morel E. Worou, Jean-Baptiste Michel, Alexandre Raoul, Melusine Didelot, Vincent Muczynski, Paulette Legendre, Francois Plenat, Guillaume Gauchotte, Marc-Damien Lourenco-Rodrigues, Olivier D. Christophe, Peter J. Lenting, Patrick Lacolley, Cecile Denis, Veronique Regnault
Summary: VWF induces VSMC proliferation through A2 domain binding to LRP4 receptor and integrin alpha(v)beta(3) signaling. These findings provide new insights into the mechanisms that drive physiological repair and pathological hyperplasia of the arterial vessel wall.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)