Article
Chemistry, Medicinal
Fernando Sabia Tallo, Patricia Oliveira de Santana, Sandra Augusta Gordinho Pinto, Rildo Yamaguti Lima, Erisvaldo Amarante de Araujo, Jose Gustavo Padrao Tavares, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Murched Omar Taha, Andre Ibrahim David, Braulio Luna-Filho, Carlos Eduardo Braga Filho, Adriano Henrique Pereira Barbosa, Celia Maria Camelo Silva, Almir Goncalves Wanderley, Adriano Caixeta, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Summary: Acute myocardial infarction is a major cause of morbidity and mortality worldwide, characterized by severe arrhythmias induced by cardiac ischemia/reperfusion. This study reveals that pharmacological modulation of the cardiac Ca2+/cAMP/adenosine signaling pathway could be a promising therapeutic strategy to reduce the incidence of severe and fatal arrhythmias caused by AMI.
Article
Biochemistry & Molecular Biology
Emily Sze-Wan Wong, Renkai Li, Jingjing Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Sai-Wang Seto, George Pak-Heng Leung
Summary: This study investigated the involvement of equilibrative nucleoside transporter 4 (ENT4) in adenosine transport in cardiomyocytes under simulated ischemic conditions. The results showed that inhibition of ENT4 could protect cardiomyocytes against ischemia-reperfusion injury. These findings suggest that ENT4 may play a role in adenosine transport in cardiomyocytes under ischemic conditions.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Mark J. Specterman, Qadeer Aziz, Yiwen Li, Naomi A. Anderson, Leona Ojake, Keat-Eng Ng, Alison M. Thomas, Malcolm C. Finlay, Richard J. Schilling, Pier D. Lambiase, Andrew Tinker
Summary: This study investigated the effects of hypoxia on atrial electrophysiology in mice with global deletion of the K-ATP pore-forming subunits. The results showed that K-ATP blockade or absence resulted in atrial electrophysiological modifications at the cellular and tissue level. Furthermore, the global knockout of Kir6.2 prevented hypoxia-induced atrial path length shortening and arrhythmogenicity, suggesting a potential translational approach for treating ischemically driven atrial arrhythmia.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Summary: Sirtuins are beneficial NAD+-dependent deacetylases that play roles in various human health conditions. In this study, researchers investigated the regulation of ATP-sensitive K+ (KATP) channels by sirtuins. They found that increasing NAD+ levels and activating sirtuins led to an increase in KATP channel current and surface expression. This finding has implications for cardiac protection against ischemic damage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang
Summary: ATP-sensitive potassium channels (K-ATP channels) play important roles in cellular excitability and metabolism. Activation of K-ATP channels can repolarize the membrane potential and reduce the occurrence of arrhythmias. Under severe and prolonged anoxia, K-ATP channels open to decrease cellular excitability and prevent action potential generation. Small active molecules can enhance the opening of K-ATP channels, leading to membrane repolarization and decreased malignant arrhythmias. Mutations in K-ATP channels worsen the regulatory roles in mutation-related diseases. However, efficient treatments for patients with K-ATP channel mutations are still lacking.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michela Pecoraro, Stefania Marzocco, Ada Popolo
Summary: This study demonstrates a cooperative relationship between mCx43 and K-ATP channels in inducing cytoprotection in cardiomyocytes under hypoxic conditions. The presence of mCx43 is essential for the protective effects of diazoxide, an opener of K-ATP channels, against CoCl2-induced mitochondrial damage. These findings highlight the close functional link between mCx43 and K-ATP channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
P. P. Tregub, N. A. Malinovskaya, E. D. Osipova, A. V. Morgun, V. P. Kulikov, D. A. Kuzovkov
Summary: The study found that the combination of hypercapnia and hypoxia can increase the relative number of A1-adenosine receptors and mitoK(ATP)(+)-channels in astrocytes, potentially enhancing their neuroprotective effects. However, hypercapnia alone does not have this effect.
NEUROMOLECULAR MEDICINE
(2022)
Article
Immunology
Lichen Chen, Jixiang Yuan, Hang Li, Yi Ding, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yuanyuan Gao, Xilong Wang, Hong Lu, Yong Cai, Yongheng Bai, Xiaodong Pan
Summary: Trans-cinnamaldehyde (TCA) extracted from cinnamon bark has anti-inflammatory properties and can attenuate renal ischemia-reperfusion injury (IRI) through inhibiting the JNK/p38 MAPK signaling pathway, thus reducing kidney pathological changes and dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski
Summary: Chronic hypoxia impairs vascular function through various mechanisms, including changes in mitochondrial respiration. Our study found that the hypoxia-mimetic agent CoCl2 reduces nitric oxide (NO) production, depletes intracellular ATP levels, and increases extracellular nucleotide and adenosine breakdown in endothelial cells (ECs). Supplementation of nucleotide precursors and inhibition of adenosine deaminase can restore ATP levels and protect endothelial function.
Article
Oncology
Xinmiao Jiang, Qiong Yan, Jiaqi He, Zeqi Zheng, Xiaoping Peng, Xiaoyan Cao, Fangbin Zhou, Jungang Nie, Ting Kang
Summary: This study suggests that Dusp2 plays a crucial role in hyperglycemia-induced vascular endothelial cell dysfunction by inhibiting Dusp2 expression and activating p38 MAPK, leading to endothelial cell proliferation, migration, and angiogenesis.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Physiology
Li Liang, Xin Gu, Hai Ji Shen, Yu Heng Shi, Yao Li, Jie Zhang, Yan Yan Chen, Zhen He Chen, Jia Yun Ma, Qing Yun Li
Summary: The study showed that chronic intermittent hypoxia (CIH) reduced glucocorticoid sensitivity by activating the p38 MAPK signaling pathway. Results demonstrated that CIH exposure increased pulmonary resistance, inflammatory cell counts, and inflammation levels in OVA-challenged mice, indicating a worsening effect on asthma when combined with CIH.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Kuan-Yi Lee, Chia-Ming Liu, Li-Han Chen, Chien-Yueh Lee, Tzu-Pin Lu, Li-Ling Chuang, Liang-Chuan Lai
Summary: This study aimed to investigate the role of tumor-suppressive circRNA circAAGAB in breast cancer. The findings suggest that circAAGAB, which is stabilized by interacting with RNA binding protein FUS, acts as a tumor suppressor by up-regulating the expression of KIAA1522, NKX3-1, and JADE3 through miR-378 h sponge. The results showed that circAAGAB reduced cell colony formation, cell migration, and signaling through the p38 MAPK pathway, as well as increased radiosensitivity.
CANCER CELL INTERNATIONAL
(2023)