Article
Cardiac & Cardiovascular Systems
Ajay Godwin Potnuri, Lingesh Allakonda, Sherin Saheera
Summary: The study found that NFkB-mediated upregulation of H2R is involved in alpha 1AR-induced cardiac hypertrophy, with famotidine and NFkB pharmacological inhibitors significantly suppressing alpha 1AR-induced H2R expression, oxidative stress, and hypertrophic indices. This suggests an interrelationship between alpha 1AR and H2R, with an increase in constitutive activity of H2R correlating with an increased receptor population.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Hannah K. Fandl, Vinicius P. Garcia, John W. Treuth, Lillian M. Brewster, Jared J. Greiner, Kevin P. Davy, Brian L. Stauffer, Christopher A. Desouza
Summary: Obesity and hypertension are associated with increased risk of heart failure, and this study explores the effects of endothelial microvesicles (EMVs) from obese/hypertensive individuals on cardiomyocyte hypertrophy and fibrosis, as well as eNOS expression and NO production.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Y. Xu, C. Li, G. Liu, H. Zhang, S. Tian, H. Hao, Y. Hao
Summary: This study found that Ang 1-7 significantly increased NO synthesis in rat VSMCs cultured under high glucose conditions by regulating Cav-1 expression, Cav-1-eNOS interaction, oxidative stress, and intracellular Ca2+ levels.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Soo Hee Lee, Seong-Chun Kwon, Seong-Ho Ok, Seung Hyun Ahn, Sung Il Bae, Yeran Hwang, Kyeong-Eon Park, Ju-Tae Sohn
Summary: The study found that linolenic acid increases phenylephrine-induced contraction by inhibiting endothelial NO release rather than decreasing [Ca2+] in vascular smooth muscle.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hawa Nordin Siti, Juriyati Jalil, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: Both rutin and quercetin exhibit similar protective effects against Ang II-induced cardiomyocyte hypertrophy, but they modulate the MAPK pathway differently.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Meryl Musicante, Hannah H. Kim, Yuanjian Chen, Fang Liao, Syamal K. Bhattacharya, Lu Lu, Yao Sun
Summary: This study revealed that eNOS plays a beneficial role in preventing cardiac myocyte hypertrophy and fibrosis, supporting the idea that eNOS may modify the severity of HCM phenotypes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Gianfranco Matrone, Sung Yun Jung, Jong Min Choi, Antrix Jain, Hon-Chiu Eastwood Leung, Kimal Rajapakshe, Cristian Coarfa, Julie Rodor, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Summary: Despite the importance of nitric oxide signaling, the role of inducible nitric oxide synthase (iNos) in nuclear translocation and S-nitrosylation in tissue regeneration has been discovered in this study. Kdm1a S-nitrosylation is shown to be crucial for tailfin regeneration, altering its binding to the CoRest complex and impairing H3K4 demethylase activity, highlighting the importance of this post-translational modification in the repair process.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Surawee Chuaiphichai, Sandy M. Chu, Ricardo Carnicer, Matthew Kelly, Jenifer K. Bendall, Jillian N. Simon, Gillian Douglas, Mark J. Crabtree, Barbara Casadei, Keith M. Channon
Summary: This study reveals a critical role for endothelial cell Gch1/BH4 biosynthesis in coronary vascular function and cardiac function. Loss of cardiac endothelial cell BH4 leads to coronary vascular dysfunction, reduced functional recovery, and increased myocardial infarct size following ischemia/reperfusion injury. Targeting endothelial cell Gch1 and BH4 biosynthesis may provide a novel therapeutic target for the prevention and treatment of cardiac dysfunction, ischemia injury, and heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Aya Al Katat, Juan Zhao, Angelino Calderone, Lucie Parent
Summary: Intracellular Ca2+ overload caused by chronic hemodynamic stimuli can stimulate Ca2+-dependent signaling and promote cardiomyocyte hypertrophy. The study found that sympathetic-mediated hypertrophy of neonatal rat ventricular cardiomyocytes (NRVMs) led to an increase in calcium influx due to upregulation of Ca(V)1.2 channel subunits. The upregulation of Ca-V alpha 2 delta 1 protein levels was found to be independent of the concomitant hypertrophic response, while the upregulation of Ca-V beta 3 protein levels may be directly dependent on the hypertrophic response of NRVMs.
Letter
Anesthesiology
Soban Umar, Mansoureh Eghbali
Article
Medicine, Research & Experimental
Gregoire Ruffenach, Soban Umar, Mylene Vaillancourt, Jason Hong, Nancy Cao, Shervin Sarji, Shayan Moazeni, Christine M. Cunningham, Abbas Ardehali, Srinivasa T. Reddy, Rajan Saggar, Gregory Fishbein, Mansoureh Eghbali
EMBO MOLECULAR MEDICINE
(2019)
Review
Physiology
Matthew Mikhael, Christian Makar, Amir Wissa, Trixie Le, Mansoureh Eghbali, Soban Umar
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Soban Umar, Gregoire Ruffenach, Shayan Moazeni, Mylene Vaillancourt, Jason Hong, Christine Cunningham, Nancy Cao, Sara Navab, Shervin Sarji, Min Li, Lisa Lee, Greg Fishbein, Abbas Ardehali, Mohamad Navab, Srinivasa T. Reddy, Mansoureh Eghbali
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Asif Razee, Soban Umar
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Laila Aryan, Lejla Medzikovic, Soban Umar, Mansoureh Eghbali
BIOLOGY OF SEX DIFFERENCES
(2020)
Article
Cardiac & Cardiovascular Systems
David J. Bae, David M. Tehrani, Soniya Rabadia, Marlene Frost, Rushi Parikh, Marcella Calfon-Press, Olcay Aksoy, Soban Umar, Reza Ardehali, Amir Rabbani, Pooya Bokhoor, Ali Nsair, Jesse Currier, Jonathan Tobis, Gregg C. Fonarow, Ravi Dave, Asim M. Rafique
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Anesthesiology
Christian D. Seger, Libing Wang, Xuezhi Dong, Peyton Tebon, Sebastian Kwon, Elaine C. Liew, Jure Marijic, Soban Umar, Nir N. Hoftman
ANESTHESIA AND ANALGESIA
(2020)
Review
Biochemistry & Molecular Biology
Laila Aryan, David Younessi, Michael Zargari, Somanshu Banerjee, Jacqueline Agopian, Shadie Rahman, Reza Borna, Gregoire Ruffenach, Soban Umar, Mansoureh Eghbali
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Critical Care Medicine
Jason Hong, Douglas Arneson, Soban Umar, Gregoire Ruffenach, Christine M. Cunningham, In Sook Ahn, Graciel Diamante, May Bhetraratana, John F. Park, Emma Said, Caroline Huynh, Trixie Le, Lejla Medzikovic, Marc Humbert, Florent Soubrier, David Montani, Barbara Girerd, David-Alexandre Tregouet, Richard Channick, Rajan Saggar, Mansoureh Eghbali, Xia Yang
Summary: This study revealed the distinct and shared dysregulation of genes and pathways in two commonly used PAH models at single-cell resolution, demonstrating their relevance to human PAH and utility for drug repositioning.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Peripheral Vascular Disease
Gregoire Ruffenach, Ellen O'Connor, Mylene Vaillancourt, Jason Hong, Nancy Cao, Shervin Sarji, Shayan Moazeni, Jeremy Papesh, Victor Grijalva, Christine M. Cunningham, Le Shu, Arnab Chattopadhyay, Shuchita Tiwari, Olaf Mercier, Frederic Perros, Soban Umar, Xia Yang, Aldrin V. Gomes, Alan M. Fogelman, Srinivasa T. Reddy, Mansoureh Eghbali
Article
Cardiac & Cardiovascular Systems
John F. Park, Varina R. Clark, Somanshu Banerjee, Jason Hong, Asif Razee, Tiffany Williams, Gregory Fishbein, Lou Saddic, Soban Umar
Summary: RV failure in monocrotaline and Sugen with hypoxia models showed similar gene expressions and biological pathways, with significant enrichment in genes related to epithelial-to-mesenchymal transition, inflammation, and metabolism. Human RV tissue from PAH-induced RV failure patients exhibited notable fibrosis, endothelial-to-mesenchymal transition, and elevated expression of cellular communication network factor 2 in perivascular areas compared to normal RV.
CIRCULATION-HEART FAILURE
(2021)
Review
Cardiac & Cardiovascular Systems
Francois Potus, Andrea L. Frump, Soban Umar, Rebecca R. Vanderpool, Imad Al Ghouleh, Yen-Chun Lai
Summary: This review focuses on breakthroughs in pulmonary hypertension research presented at the ATS2020 Conference, highlighting the understanding of mechanisms underlying RV failure, inflammation regulation, and novel therapeutic targets. It also discusses the pathological interactions between pulmonary hypertension, right ventricular function, and COVID-19.
PULMONARY CIRCULATION
(2021)
Letter
Anesthesiology
Anjum Anwar, Christian Seger, Ashley Tollefson, Carol Ann B. Diachun, Pedro Tanaka, Soban Umar
JOURNAL OF CLINICAL ANESTHESIA
(2020)
Review
Cardiac & Cardiovascular Systems
John F. Park, Somanshu Banerjee, Soban Umar
PULMONARY CIRCULATION
(2020)