Article
Biotechnology & Applied Microbiology
Eerik Aunin, Matthew Berriman, Adam James Reid
Summary: Genome architecture, reflecting evolutionary pressures, can be characterized using the new tool Genome Decomposition Analysis (GDA). GDA is designed to efficiently explore high-quality genome assemblies and discover hidden features, with demonstrated effectiveness in characterizing genome architectures of single-celled eukaryotic parasites.
Article
Multidisciplinary Sciences
Asma S. Khelifa, Cecilia Guillen Sanchez, Kevin M. Lesage, Ludovic Huot, Thomas Mouveaux, Pierre Pericard, Nicolas Barois, Helene Touzet, Guillemette Marot, Emmanuel Roger, Mathieu Gissot
Summary: Khelifa et al. identified a key transcriptional regulator, TgAP2IX-5, in the model Apicomplexan Toxoplasma gondii, which controls the timing of daughter cell emergence and regulates the expression of necessary transcription factors for completion of the budding cycle. Additionally, TgAP2IX-5 acts as a limiting factor by promoting the inhibition of the differentiation pathway, ensuring the continuation of asexual proliferation.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Shikha Shikha, Mariana Ferreira Silva, Lilach Sheiner
Summary: Mitochondrial ribosomes are crucial for the function and survival of eukaryotes, but different lineages have evolved divergent features in their mitochondrial ribosomes. The study of apicomplexan mitochondrial ribosomes, which are essential for the parasites, is still limited due to the unknown composition. In this study, the components of the mitoribosomal large subunit in the model apicomplexan Toxoplasma gondii were identified and validated to facilitate further research.
Review
Microbiology
Julie M. J. Verhoef, Markus Meissner, Taco W. A. Kooij
Summary: Apicomplexan parasites such as Toxoplasma gondii and Plasmodium falciparum replicate through different methods and require tightly coordinated organelle division and distribution. While proper organelle segregation is crucial, the molecular mechanisms and key proteins involved are still largely unknown.
Article
Public, Environmental & Occupational Health
Fengyue Hu, Qicheng Zou, Yinyue Li, Guoding Zhu, Huayun Zhou, Meihua Zhang, Fang Tian, Yaobao Liu, Feng Lu
Summary: This study demonstrates the feasibility of using the 23-SNP barcode to track P. falciparum, with results showing that most P. falciparum isolates originate from West Africa, while also revealing some isolates from Central Africa that originated in East Africa.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Ecology
Annie Z. Tremp, Sadia Saeed, Johannes T. Dessens
Summary: This study systematically analyzed nth genes across eukaryotic life and found that NTH is widely distributed in all major lineages, but some organisms (especially plants) completely lack nth genes. Isoform distribution and phylogenetic analysis revealed different nth gene loss scenarios in apicomplexan lineages, shedding new light on the evolution of the Piroplasmida and Eimeriidae.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Review
Cell Biology
Kerry Woods, Carmen Perry, Francis Bruehlmann, Philipp Olias
Summary: Following invasion by Theileria sporozoites, one of the first events is the destruction of the host cell membrane and rapid association with host microtubules. Theileria species transform bovine cells by rewiring signaling pathways and controlling mitotic machinery. Theileria-encoded proteins can modify host gene expression, but their mode of action and secretion pathways are not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Josie Liane Ferreira, Dorothee Heincke, Jan Stephan Wichers, Benjamin Liffner, Danny W. Wilson, Tim-Wolf Gilberger
Summary: The Edo period in Japan was a unique historical period during which the Japanese people developed distinctive cultural and social characteristics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Marlies Monnens, Ali Halajian, D. Tim J. Littlewood, Andrew G. Briscoe, Tom Artois, Maarten P. M. Vanhove
Summary: This study characterizes a new mitochondrial genome for Clinostomum complanatum and reveals the population structure of this parasitic flatworm. It suggests that genetic exchange between different geographic populations of C. complanatum is facilitated by avian migratory routes. The study also highlights the importance of using new or additional mitochondrial markers for high-resolution diagnostics and population biology.
Article
Medicine, General & Internal
Dianpeng Wang, Xiangli Yang, Diya Cai, Peimao Li, Zhimin Zhang, Dafeng Lin, Yanfang Zhang
Summary: This study analyzed gene mutations in a female patient with chronic benzene exposure, finding 98 mutations with 25 frame shifts, and the highest mutation rate in the ND6 gene. After treatment, the patient's blood routine test indicators returned to normal, indicating that timely intervention can achieve good results.
Review
Microbiology
Manish Goyal, Karina Simantov, Ron Dzikowski
Summary: SR proteins play an important role in eukaryotic gene expression by regulating splicing events and acting as key regulators of RNA metabolism. Plasmodium parasites encode several SR proteins, which might have noncanonical functions in addition to splicing regulation.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
M. Andreina Pacheco, Randall E. Junge, Adithyan Menon, Jon McRoberts, Gediminas Valkiunas, Ananias A. Escalante
Summary: This study found six Plasmodium lineages in lemurs, indicating that lemurs play a role in the transmission of malaria parasites. The analysis of mitochondrial genomes and apicoplast loci suggests that the lemur Plasmodium clade shares a common ancestor with primate parasites from continental Africa, and the most lethal malaria parasite in humans, Plasmodium falciparum, may have originated from African apes. Furthermore, the study revealed a close phylogenetic relationship between lemurs and their parasites, with evidence of cospeciation, duplication, and host switching events.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Celia Miguel-Blanco, James M. Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A. Sala, Donelly A. van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J. Fuchter, Oliver Billker, Colin J. Sutherland, Susana G. Campino, Taane G. Clark, Andrew M. Blagborough, David A. Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J. Delves
Summary: New antimalarial therapeutics are urgently needed to combat emerging parasite and mosquito resistance. Intense drug screening efforts have identified promising new antimalarial molecules with novel modes of action to combat existing drug resistance.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Julie Boisard, Evelyne Duvernois-Berthet, Linda Duval, Joseph Schrevel, Laure Guillou, Amandine Labat, Sophie Le Panse, Gerard Prensier, Loic Ponger, Isabelle Florent
Summary: Our current understanding of the evolutionary history, coding, and adaptive capacities of Apicomplexa is biased towards species infecting humans, and limited information is available for early diverging apicomplexan lineages infecting invertebrates. In this study, the genome of Porospora gigantea, a marine eugregarine parasite of lobsters, was characterized. The genome analysis revealed high divergence from other known apicomplexan species and provided insights into the molecular basis of key functions such as gliding. These findings highlight the importance of studying gregarines to broaden our knowledge of apicomplexan species diversity and their molecular mechanisms.
Review
Microbiology
Luisa Berna, Natalia Rego, Maria E. Francia
Summary: Mitochondria are essential organelles in eukaryotic cells, with unique structural and functional features in Apicomplexa parasites, making them a potential source of drug targets. Studies have shown extensive diversity in the mitochondrial genomes and functions of Apicomplexa parasites, with deeper insights gained through third generation sequencing technologies.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Emi Sasagawa, Hirotsugu Aiga, Edith Yanira Corado Soriano, Blanca Leticia Cuyuch Marroquin, Marta Alicia Hernandez Ramirez, Ana Vilma Guevara de Aguilar, Jose Eduardo Romero Chevez, Hector Manuel Ramos Hernandez, Rafael Antonio Cedillos, Chizuru Misago, Kiyoshi Kita
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Microbiology
Shigeo Suzuki, Kenji Hikosaka, Emmanuel O. Balogun, Keisuke Komatsuya, Mamoru Niikura, Fumie Kobayashi, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Kiyoshi Kita
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Biochemistry & Molecular Biology
Masaki Ohtawa, Mari Matsunaga, Keiko Fukunaga, Risa Shimizu, Eri Shimizu, Shiho Arima, Junko Ohmori, Kiyoshi Kita, Kazuro Shiomi, Satoshi Omura, Tohru Nagamitsu
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Daniel Ken Inaoka, Tomoo Shiba, Dan Sato, Emmanuel Oluwadare Balogun, Tsuyoshi Sasaki, Madoka Nagahama, Masatsugu Oda, Shigeru Matsuoka, Junko Ohmori, Teruki Honma, Masayuki Inoue, Kiyoshi Kita, Shigeharu Harada
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Article
Biotechnology & Applied Microbiology
Kei Katsuno, Jeremy N. Burrows, Ken Duncan, Rob Hooft van Huijsduijnen, Takushi Kaneko, Kiyoshi Kita, Charles E. Mowbray, Dennis Schmatz, Peter Warner, B. T. Slingsby
NATURE REVIEWS DRUG DISCOVERY
(2015)
Article
Parasitology
Josephine E. Siregar, Genji Kurisu, Tamaki Kobayashi, Motomichi Matsuzaki, Kimitoshi Sakamoto, Fumika Mi-ichi, Yoh-ichi Watanabe, Makoto Hirai, Hiroyuki Matsuoka, Din Syafruddin, Sangkot Marzuki, Kiyoshi Kita
PARASITOLOGY INTERNATIONAL
(2015)
Article
Parasitology
Kenji Hikosaka, Makoto Hirai, Keisuke Komatsuya, Yasuo Ono, Kiyoshi Kita
PARASITOLOGY INTERNATIONAL
(2015)
Article
Biochemistry & Molecular Biology
Yumiko Shiobara, Chiaki Harada, Takeshi Shiota, Kimitoshi Sakamoto, Kiyoshi Kita, Saeko Tanaka, Kenta Tabata, Kiyoteru Sekie, Yorihiro Yamamoto, Tomoyasu Sugiyama
Article
Infectious Diseases
Makoto Matsubayashi, Fumiya Kawahara, Takeshi Hatta, Junya Yamagishi, Takeharu Miyoshi, Anisuzzaman, Kazumi Sasai, Takashi Isobe, Kiyoshi Kita, Naotoshi Tsuji
INFECTION GENETICS AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Hiroki Hayase, Nobumoto Watanabe, Chung Liang Lim, Toshihiko Nogawa, Keisuke Komatsuya, Kiyoshi Kita, Hiroyuki Osada
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Takuma Suematsu, Osamu Watanabe, Kiyoshi Kita, Shin-ichi Yokobori, Yoh-ichi Watanabe
JOURNAL OF BIOCHEMISTRY
(2014)
Article
Veterinary Sciences
Makoto Matsubayashi, Takeshi Hatta, Takeharu Miyoshi, Anisuzzaman, Kazumi Sasai, Kayoko Yamaji, Kameo Shimura, Takashi Isobe, Kiyoshi Kita, Naotoshi Tsuji
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2014)
Article
Parasitology
Emi Sasagawa, Ana Vilma Guevara de Aguilar, Marta Alicia Hernandez de Ramirez, Jose Eduardo Romero Chevez, Jun Nakagawa, Rafael Antonio Cedillos, Kiyoshi Kita
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2014)
Article
Multidisciplinary Sciences
Ryunosuke Yoshino, Nobuaki Yasuo, Daniel Ken Inaoka, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Tomoo Shiba, Shigeharu Harada, Teruki Honma, Emmanuel Oluwadare Balogun, Josmar Rodrigues da Rocha, Carlos Alberto Montanari, Kiyoshi Kita, Masakazu Sekijima
Article
Public, Environmental & Occupational Health
Emi Sasagawa, Hirotsugu Aiga, Edith Y. Corado, Blanca L. Cuyuch, Marta A. Hernandez, Ana V. Guevara, Jose E. Romero, Hector M. Ramos, Rafael A. Cedillos, Chizuru Misago, Kiyoshi Kita
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2015)