期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 172, 期 2, 页码 66-79出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2010.04.001
关键词
Trypanosoma; Phospholipids; Sphingolipids; Fatty acids; Biosynthesis; Metabolism; Gene IDs
资金
- Wellcome Trust [067441, 086658]
- Biotechnology and Biological Sciences Research Council
- Swiss National Science Foundation [31003A-116627]
- Sinergia [CRSII3_127300]
- COST action [BM0802]
- Swiss National Science Foundation (SNF) [CRSII3_127300] Funding Source: Swiss National Science Foundation (SNF)
Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites. (C) 2010 Elsevier B.V. All rights reserved.
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