期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 167, 期 1, 页码 12-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbiopara.2009.04.009
关键词
C1 cysteine peptidase; Parasite; Cathepsin; Trypanosoma; Leishmania; Cryptobia; Nomenclature; Diagnosis; Vaccine; Chemotherapy
Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic Organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed. (C) 2009 Elsevier B.V. All rights reserved.
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