期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 163, 期 1, 页码 61-65出版社
ELSEVIER
DOI: 10.1016/j.molbiopara.2008.09.001
关键词
RNA binding protein; Trypanosoma; RRM
In eukaryotes, proteins containing RNA Recognition Motifs (RRMs) are involved in many different RNA processing reactions, RNA transport, and mRNA decay. Kinetoplastids rely extensively on post-transcriptional mechanisms to control gene expression, so RRM domain proteins are expected to play a prominent role. We here describe the results of an RNA interference screen targeting 37 of the 72 RRM-domain proteins of Trypanosoma brucei. RNAi targeting 8 of the genes caused clear growth inhibition in bloodstream trypanosomes, and milder effects were seen for 9 more genes. The small, single-RRM protein TbRBP3 specifically associated with 10 mRNAs in trypanosome lysates, but RBP3 depletion did not affect the transcriptome. (C) 2008 Elsevier B.V. All rights reserved.
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