Article
Medicine, Research & Experimental
Lianxiang Luo, Fangfang Huang, Saiyi Zhong, Rui Ding, Jiating Su, Xiaoling Li
Summary: In this study, it was found that astaxanthin can inhibit inflammation and ferroptosis by regulating the Keap1-Nrf2/HO-1 pathway, thereby reducing the occurrence and development of LPS-induced ALI.
Article
Biochemistry & Molecular Biology
Shihui Guo, Aiying Zhong, Dongxu Zhang, Jiang Gao, Yingdong Ni, Ruqian Zhao, Wenqiang Ma
Summary: Ferroptosis is involved in the development of neurological disorders, and regulating ferroptosis shows potential therapeutic effects in nervous system diseases. The study identified ATP2B3 as a target protein through TMT-based proteomic analysis, and inhibiting ATP2B3 alleviated erastin-induced ferroptosis in HT-22 cells by modulating the P62-KEAP1-NRF2-HO-1 pathway. Other interventions targeting related proteins also reversed the effects of ferroptosis. Overall, this study highlights the importance of ATP2B3 inhibition in mitigating ferroptosis in HT-22 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jiucui Li, Kongmiao Lu, Fenglan Sun, Shanjuan Tan, Xiao Zhang, Wei Sheng, Wanming Hao, Min Liu, Weihong Lv, Wei Han
Summary: Panaxydol (PX) isolated from Panax ginseng roots attenuates ferroptosis against LPS-induced ALI via the Keap1-Nrf2/HO-1 pathway, showing promising therapeutic potential for ALI treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Tao-lin Qing, Lang Yan, Shao-kang Wang, Xiao-yu Dai, Li-jun Ren, Ji-qian-zhu Zhang, Wen-jing Shi, Xiao-fang Zhang, Mei-tang Wang, Ji-kuai Chen, Jiang-bo Zhu
Summary: The study found that multi-walled carbon nanotubes (MWCNTs) induce oxidative stress by overproducing reactive oxygen species (ROS), leading to cytotoxicity. However, celastrol, a plant-derived compound, has antioxidant effects by reducing ROS production. The results showed that MWCNT exposure decreased cell viability and increased ROS production. Knockdown of Nrf2 increased ROS production and cytotoxicity, while knockdown of Keap1 decreased ROS production and attenuated cytotoxicity. Treatment with celastrol significantly reduced ROS production and promoted Keap1 degradation, leading to increased Nrf2 translocation to the nucleus and increased HO-1 expression. In vivo results demonstrated that celastrol alleviated inflammatory damage in lung tissues, increased levels of antioxidants, GSH and SOD, and promoted HO-1 expression in MWCNT-treated mice. Therefore, celastrol can alleviate MWCNT-induced oxidative stress through the Keap1/Nrf2/HO-1 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Fengyang Wu, Fengxia Wang, Zhaohong Tang, Xinyu Yang, Yanhua Liu, Man Zhao, Shudong Liu, Shuaijuan Han, Zhisheng Zhang, Baojiang Chen
Summary: This study assessed the alleviative effect of quercetagetin (QG) on zearalenone (ZEN)-induced liver injury in rabbits. The results showed that QG could alleviate oxidative damage and liver injury caused by ZEN, providing a new perspective for developing an antidote for ZEN toxicity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Sibo Wang, Hongzhi Wu, Yunhui Zhu, Hongxia Cui, Ji Yang, Mingyuan Lu, Huangzuo Cheng, Lihong Gu, Tieshan Xu, Li Xu
Summary: The objective of this study was to determine the effect of dietary lycopene supplementation on the growth performance, antioxidant enzyme activity, and gene expressions in the liver of Arbor Acres broilers. The results showed that lycopene supplementation improved the growth performance, antioxidant enzyme activity, and gene expressions related to the Keap1-Nrf2 signaling pathway in the broilers.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Bo-Jeong Pyun, Kyuhyung Jo, Joo Young Lee, Ami Lee, Myung-A Jung, Youn-Hwan Hwang, Dong Ho Jung, Kon-Young Ji, Susanna Choi, Yun Hee Kim, Taesoo Kim
Summary: Caesalpinia sappan Linn. heartwood water extract (CSLW) has anti-inflammatory and antioxidant properties and can alleviate symptoms of allergic rhinitis (AR) by controlling the allergic inflammatory reaction of the nasal epithelium.
Article
Biochemistry & Molecular Biology
Agnieszka Irena Mazur-Bialy, Ewa Pochec
Summary: This study found that irisin effectively reduced free radical production by macrophages and altered the kinetics of key factors in the Nrf2/HO-1/HMGB1 pathway, leading to increased production of Nrf2 and HO-1 while significantly reducing HMGB1 release.
Article
Genetics & Heredity
Senling Feng, Yongheng Zhou, Hongliang Huang, Ying Lin, Yifeng Zeng, Shanshan Han, Kaikai Huang, Quanzhi Liu, Wenting Zhu, Zhongwen Yuan, Baoying Liang
Summary: Nobiletin, a natural product, induces ferroptosis in melanoma cells by regulating the GSK3β-mediated Keap1/Nrf2/HO-1 signaling pathway, demonstrating its potential as an anti-tumor agent.
FRONTIERS IN GENETICS
(2022)
Article
Plant Sciences
Shusheng Fan, Xiaoyun Liu, Yu Wang, Xueyang Ren, Yue Liu, Ying Dong, Qiqi Fan, Jing Wei, Jiamu Ma, Axiang Yu, Ruolan Song, Hong Sui, Meng Shen, Fang Fang, Qing Xia, Gaimei She
Summary: Thymus quinquecostatus contains abundant polyphenols and shows a good protective effect against cerebral ischemia-reperfusion injury through dual antioxidant mechanisms, providing a valuable reference for further research and application.
Article
Medicine, Research & Experimental
Emad H. M. Hassanein, Hanan S. Althagafy, Ahmed M. Atwa, Magy R. Kozman, Mohamed. I. Kotb El-Sayed, Ayman A. Soubh
Summary: Taurine has protective effects against MTX-induced intestinal injury through antioxidative, anti-inflammatory, and antiapoptotic mechanisms. This study provides evidence for taurine as a potential therapeutic agent for alleviating the adverse effects of MTX.
Article
Food Science & Technology
Haoyang Sun, Meiling Zhang, Jianping Li, Anshan Shan
Summary: The study found that selenomethionine could partly reverse the oxidative damage and cell death caused by Zearalenone toxins, through a Nrf2/Keap1-ARE pathway.
Article
Pharmacology & Pharmacy
Kai Shi, Bing Wang
Summary: Ruscogenin (RUS) enhances cell viability while alleviating cytotoxicity, lipid peroxidation and mitochondrial dysfunction in a Parkinson's disease (PD) model through the activation of the Keap1/Nrf2/HO-1 signaling pathway.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi
Summary: ROS play a crucial role in cellular processes, with Keap1-Nrf2 pathway acting as a master antioxidant mechanism. While activation of Nrf2 benefits cells in early stages by reducing ROS levels, hyperactivation can support the survival of healthy and cancer cells against oxidative stress and treatments. Understanding the dual role of Nrf2 in cancer cells can be important in cancer treatment strategies.
Article
Biochemistry & Molecular Biology
Chuan Wei, Xiaoling Chen, Daiwen Chen, Bing Yu, Ping Zheng, Jun He, Hong Chen, Hui Yan, Yuheng Luo, Zhiqing Huang
Summary: This study found that dihydromyricetin (DHM) enhances the intestinal antioxidant capacity of growing-finishing pigs by activating the ERK/Nrf2/HO-1 signaling pathway.
Article
Environmental Sciences
Lei Zhang, Jiahuai Zhang, Sai Fan, Yuxin Zhong, Jingguang Li, Yunfeng Zhao, Song Ni, Jiaying Liu, Yongning Wu
Summary: This case-control study investigated the associations between urinary concentrations of bisphenols and the risk of papillary thyroid cancer (PTC). The results showed significant positive associations between bisphenol F (BPF) concentration and PTC risk, but negative associations between bisphenol A (BPA) and bisphenol S (BPS) concentrations and PTC risk in the overall population. However, the significant associations were only observed in non-smoking women after stratification by age and smoking.
Article
Engineering, Environmental
Feng Han, Jiaying Liu, Yuxin Wang, Jingguang Li, Bing Lyu, Yunfeng Zhao, Yongning Wu
Summary: The mechanism of blood to milk transfer of PFOS and Cl-PFESAs was studied using 145 paired maternal serum and human milk samples. The transfer efficiency was found to be influenced by the physicochemical properties and primary components of human milk. Results suggest that passive diffusion through the paracellular route may be the main transfer pathway for PFOS and Cl-PFESAs from blood to milk.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yizhong Shen, Yunlong Wei, Xiang Gao, Chao Nie, Jianlong Wang, Yongning Wu
Summary: Scientists successfully synthesized a novel blue fluorescence nanozyme CeO2@TPE with high peroxidase-like activity. By embedding aggregation-induced emission (AIE) tetraphenylethene (TPE) into hollow CeO2 nanospheres and combining ethanol oxidase (AOX) and o-phenylenediamine (OPD), they developed an enzymatic cascade activation ratiometric fluorescence-colorimetric dual-mode system for detecting methyl mercaptan (CH3SH). This study provides a new insight into designing target-responsive enzymatic cascade activation systems and enables real-time point-to-point detection of environmental health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Infectious Diseases
Danxia Gu, Zelin Yan, Chang Cai, Jiaping Li, Yanyan Zhang, Yuchen Wu, Jiaxing Yang, Yonglu Huang, Rong Zhang, Yongning Wu
Summary: In this study, the efficacy of three different methods for the rapid detection of carbapenemases (KPC, NDM, IMP, OXA-48, and VIM) was evaluated. The NG-test Carba 5, colloidal gold immunoassay (CGI) test, and Xpert Carba-R assay showed reliable performances in carbapenemase detection, with Xpert Carba-R being recommended for the detection of KPC variants.
Article
Chemistry, Analytical
Xu Zhang, Chaochen Sun, Ruiling Li, Yongning Wu, Xin Jin, FengFu Fu
Summary: This study presents a reusable magnetic enzyme-loading nanoplatform with enhanced peroxidase-like activity for developing colorimetric sensors. It demonstrates stable and enhanced peroxidase-like activity, good enzyme-loading capacity, and magnetic separation capability, which enables the fabrication of sensitive and simple colorimetric sensors. It also successfully detects glucose and cholesterol with high recovery and low relative standard deviation.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Feifei Huang, Lei Zhang, Moqin Zhou, Jianwen Li, Qing Liu, Bo Wang, Ke Deng, Pingping Zhou, Yongning Wu
Summary: Polycyclic aromatics hydrocarbons (PAHs) are commonly found in foods and the environment and have carcinogenic and mutagenic potential. A study in China determined the concentrations of 16 PAHs in commonly consumed food items. Edible vegetable oils had the highest concentration of PAHs, while fruits had the lowest. PAH4 was identified as a suitable indicator for PAH contamination, and the overall dietary exposure for PAHs in the Chinese population was estimated to be within safe limits.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Agriculture, Multidisciplinary
Chi Zhang, Heli Li, Huijing Shen, Bing Lyu, Shaohua Li, Jingguang Li, Yunfeng Zhao, Dawei Chen, Yongning Wu
Summary: This study is the first nationwide study in China on the chronic health risks of chlorothalonil and its metabolite (4-OH-chlorothalonil) for Chinese adults and breastfed infants. The study found that chlorothalonil and 4-OH-chlorothalonil were detected in dietary samples, with higher levels in Northwest China and Shandong regions. Other exposure routes besides dietary intake were also identified. The study concluded that the chronic health risks from dietary exposure to chlorothalonil and 4-OH-chlorothalonil are low for Chinese adults and breastfed infants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Lan Ma, Huijing Shen, Xiaohong Shang, Shuang Zhou, Bing Lyu, Xin Zhao, Jingguang Li, Yunfeng Zhao, Yongning Wu
Summary: The recent total diet study comprehensively evaluated the intake of nutrient elements in the general Chinese population. Plant foods were the main source of both macro-elements and trace elements. The average intake of Na, Ca, Mg, Zn, and Se did not meet the health guidance values, while the intake of K, P, Mn, Fe, Cu, Mo, and Cr fell within a reasonable range. A dietary imbalance was identified in the Na/K ratio and Ca/P ratio. This study highlights the importance of salt reduction and dietary structure optimization for the population.
Article
Nutrition & Dietetics
Hangyu Yu, Rui Wang, Yunfeng Zhao, Yan Song, Haixia Sui, Yongning Wu, Hongjian Miao, Bing Lyu
Summary: The sixth Total Diet Study (TDS) of China conducted a nationwide study to evaluate the health effects of MSG. The study analyzed 168 samples from seven food categories of the typical Chinese daily diet to determine MSG content, consumption patterns, and associated risks. The study found that the highest MSG level in the Chinese population's daily diet was 8.63 g/kg. By combining food consumption and MSG content measurements, the estimated MSG intake for the general population of China was 17.63 mg/kg bw/d, while the apparent consumption alone resulted in an overestimated intake of 40.20 mg/kg bw/d due to the omission of MSG loss during cooking. The study also compared and analyzed MSG content, food category contributions, and ingestion levels across different nations to provide a global perspective. Furthermore, a realistic, logical, and precise risk assessment protocol for daily MSG intake was developed in this article.
Article
Engineering, Environmental
Xin Liu, Lei Zhang, Jiaying Liu, Gerili Zaya, Yuxin Wang, Qian Xiang, Jingguang Li, Yongning Wu
Summary: Growing toxicologic evidence suggests that emerging perfluoroalkyl substances (PFASs), like chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA), may be as toxic or more toxic than perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA). This study examined the effects of these substances on newborn thyroid homeostasis and found that 6:2 Cl-PFESA has a more pronounced impact on newborns' thyroid homeostasis compared to PFOS. The findings suggest the importance of comparing the thyroid disruption caused by emerging and legacy PFASs in human health risk assessment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Yajie Wang, Jing Cao, Guanzhao Wang, Tao Wei, Kexin Hu, Wenqi Yi, Pingyang Zeng, Huifang Li, Yongning Wu, Qinghua He
Summary: Three ZIFs materials were synthesized and applied to the adsorption and detoxification of gossypol in cottonseed oil. The materials exhibited good crystal structure, thermal stability, and high specific surface area. The adsorption processes followed pseudo-second-order kinetics and were better described by the Langmuir model. The ZIFs materials showed high detoxification rates in both spiked and real cottonseed oil samples.
Article
Food Science & Technology
Hui -Ming Chen, Quan Zhou, Li-Jun Huang, Jun Lin, Jia-Fei Liu, Zi-Yong Huang, Rong-Lin Zhang, Jing-Jing Wang, Yong Zhao, Yong-Ning Wu, Xing-Fen Yang, Wei-Liang Wu
Summary: This study aimed to evaluate the effects of curcumin-mediated photodynamic treatment (PDT) on the shelf-life quality of ready-to-eat salmon fillets. The results showed that PDT had outstanding bacterial inhibition and extended the shelf-life of salmon fillets. Additionally, PDT was able to maintain the physicochemical indicators and freshness of the salmon fillets, and improve the sensory scores.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Guojian Wu, Abudoushukeer Dilinaer, Peng Nie, Xin Liu, Zhi Zheng, Pengjie Luo, Wenjuan Chen, Yongning Wu, Yizhong Shen
Summary: Developing efficient meat freshness assays is crucial for ensuring food safety. In this study, a bimetallic nanozyme Fe@CeO2 with high peroxidase-like activity was synthesized, and a self-supplying enzymatic cascade catalytic system was developed for colorimetric and photothermal detection of meat freshness. The assay showed both reliability and sensitivity, providing new insights for onsite visual monitoring of meat freshness.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Luyao Zhang, Jialu Liu, Bufan Xu, Di Wu, Yongning Wu, Guoliang Li
Summary: In this study, the effects of exposure to different concentrations of beta-carbolines norharman and harman on the survival rate and behaviors of C. elegans were assessed. The changes in antioxidant system, neurotransmitter levels, and acetylcholinesterase activity were evaluated. RNA-seq analysis identified potential molecular mechanisms underlying the toxic effects of norharman and harman. The results suggest that long-term exposure to low doses of beta-carbolines in food poses a risk of neurotoxicity.
Review
Chemistry, Analytical
Jin Liu, Guoliang Li, Jianghua Liu, Panxue Wang, Di Wu, Xianlong Zhang, Yongning Wu
Summary: PCBs, a class of synthetic organochlorine chemicals, had been widely used in industrial and commercial applications in the last century. However, PCBs have significant impacts on human health and the ecosystem, including neurotoxicity and carcinogenicity. This review mainly focuses on the recent progress in the toxicity and detection techniques of PCBs in the environment and food, covering classification, source, distribution, and toxicity, as well as sample preparation and analytical determination technologies.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)