Article
Biochemistry & Molecular Biology
Setsuko Komatsu, Kazuki Murata, Sayuri Yakeishi, Kazuyuki Shimada, Hisateru Yamaguchi, Keisuke Hitachi, Kunihiro Tsuchida, Rumina Obi, Shoichi Akita, Ryo Fukuda
Summary: Fiber crosslinked with zinc oxide nanoparticles (NPs) was found to enhance soybean growth. Compared to the solution form of ZnO NPs, fiber crosslinked with ZnO NPs promoted soybean growth at a lower concentration. Proteomic analysis revealed that proteins involved in photosynthesis and secondary metabolism accumulated more in soybeans grown on fiber crosslinked with ZnO NPs. Additionally, the abundance of NADPH oxidoreductase, which increased in soybeans by ZnO NPs application, might be related to the growth-promoting effect of auxin with fiber crosslinked with ZnO NPs on soybean growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yun Tan, Wei Zhang, Zhaoqin Zhu, Niu Qiao, Yun Ling, Mingquan Guo, Tong Yin, Hai Fang, Xiaoguang Xu, Gang Lu, Peipei Zhang, Shuangshuang Yang, Ziyu Fu, Dongguo Liang, Yinyin Xie, Ruihong Zhang, Lu Jiang, Shuting Yu, Jing Lu, Fangying Jiang, Jian Chen, Chenlu Xiao, Shengyue Wang, Shuo Chen, Xiu-Wu Bian, Hongzhou Lu, Feng Liu, Saijuan Chen
Summary: The study analyzed clinical laboratory tests, proteomes, and transcriptomes of 963 patients to understand the host responses in COVID-19 progression. Hypercortisolemia was identified as a probable cause of acute lymphocytopenia, while lung cells were found to be potential sources of elevated cytokines mediating systemic immune responses and organ damages. The study provides insights into developing further diagnostics and therapy for COVID-19.
Article
Biochemistry & Molecular Biology
Jung-Taek Kwon, Yoonjin Kim, Seonyoung Choi, Byung-Ll Yoon, Hyun-Sook Kim, Ilseob Shim, Donggeun Sul
Summary: This study provides insights into the cytotoxicity, immunotoxicity, and oxidative stress induced by CuO NPs in rat lungs. Proteomic analysis identified potential toxicological biomarkers of CuO NPs and revealed the underlying toxicity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Natalia Shoman, Ekaterina Solomonova, Arkady Akimov, Olga Rylkova
Summary: The primary patterns of alterations in Isochrysis galbana's morphology, structure, function, fluorescence, and cytometric characteristics under the impact of different concentrations of copper in ionic and nanoform were investigated. It was found that copper in nanoform is approximately 10 times less harmful than copper in its ionic form. Both types of copper had similar effects on cells, including growth inhibition, reduced photosynthetic efficiency, increased chlorophyll a volume and intracellular concentration, increased reactive oxygen species production, and decreased esterase activity. CuO NPs significantly affected the cell wall surface mechanically. The final density of cultures in the stationary growth phase depended on the introduced concentration of the contaminant and decreased with increasing initial copper content. At sublethal concentrations, I. galbana culture was divided into sensitive and resistant subpopulations, with the latter being able to ensure population survival and recovery under favorable conditions.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Materials Science, Biomaterials
Xiongcheng Xu, Yanjin Lu, Ling Zhou, Mengjiao He, Jin Zhuo, Quan Zhong, Kai Luo, Jinxin Lin
Summary: The Cu-bearing Ti6Al4V alloy can ameliorate osteoporotic macrophage responses under infectious conditions by inhibiting M1 polarization and promoting M2 phenotype, as well as enhancing anti-inflammatory cytokine release. In addition, it effectively boosts COMMD1 activity to potentially repress NF-kappa B-mediated transcription, showing promise for developing a GBR-barrier membrane for alveolar bone regeneration in osteoporosis patients.
REGENERATIVE BIOMATERIALS
(2021)
Article
Plant Sciences
Kubra Alp, Hakan Terzi, Mustafa Yildiz
Summary: The application of exogenous NO donor SNP was found to alleviate Cd-induced growth inhibition in barley seedlings. Proteomic analysis revealed that NO influenced various pathways, including photosynthesis and carbohydrate metabolism, protein metabolism, energy metabolism, stress defense, and signal transduction, thereby enhancing Cd tolerance in barley seedlings.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2022)
Article
Chemistry, Multidisciplinary
Jiayan Chen, Liping Lu, Chunlong Zhang, Xiaoming Zhu, Shulin Zhuang
Summary: In this study, it was found that black phosphorus nanomaterials have adverse effects on vasculature, with BPNSs being more likely to cause endothelial dysfunction and platelet adhesion. The impact on eNOS also differs between BPQDs and BPNSs. Although there was no significant structural damage in the mouse aortas, both BPQDs and BPNSs triggered aberrations in the aortic transcriptome, involving vasoconstriction abnormalities, metabolic disturbances, and immune perturbations.
Review
Immunology
Vladimir Mulens-Arias, Jose Manuel Rojas, Domingo F. Barber
Summary: The synthesis and functionalization of iron oxide nanoparticles have sparked interest in studying them as theranostic agents, particularly in the field of cancer immunotherapy. Understanding the effects of IONPs on the immune system is crucial, as they may impact immune cell responses through various mechanisms. Furthermore, harnessing the properties of IONPs could lead to the development of innovative therapies for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Chen Xu, Yiqun Li, Zidong Xiao, Jie Yang, Mingyang Xue, Nan Jiang, Yan Meng, Wenzhi Liu, Yuding Fan, Yong Zhou
Summary: Cyprinid herpesvirus 2 (CyHV-2) is a double-stranded DNA virus that causes severe herpesviral hematopoietic necrosis disease (HVHND) in gibel carp. This study used proteomic and phosphoproteomic analysis methods to uncover the host response to CyHV-2 infection in the kidneys of symptomatic and diseased gibel carp. The results showed that proteins involved in energy generation and ion balance were downregulated in the host after CyHV-2 infection, and phosphorylated proteins mainly participated in the regulation of RNA processing, translation, cytoskeleton organization, and immunoreaction. Furthermore, potential host kinases that interacted with viral proteins were identified, which could be candidate targets for disease treatment in the future.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Chemistry, Inorganic & Nuclear
Mehran Alavi, Masoud Moradi
Summary: Bio-fabrication of silver, copper, and copper oxide nanoparticles and nanocomposites using medicinal plant species and bacteria may provide a novel alternative strategy to combat multidrug-resistant bacteria. This literature review discusses recent studies and challenges related to the antibacterial and photocatalytic capacities of biosynthesized silver and copper nanoparticles and nanocomposites from two sources. The antibacterial activity and mechanisms, as well as the photodegradation process, are important factors to consider in future investigations.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Plant Sciences
Eugeny Boltenkov, Elena Artyukova, Anna Trias-Blasi
Summary: This study revised the taxonomy of Iris subser. Chrysographes through molecular and morphological studies, confirming its monophyletic nature and identifying four distinct lineages within the group. Additionally, it provided a revised taxonomic treatment and an identification key for the species in this group.
Article
Plant Sciences
Jing Zhou, Junmei Niu, Xinyue Wang, Jiarui Yue, Shilin Zhou, Zhenwen Liu
Summary: This study sequenced the complete chloroplast genomes of six Sium species and found that they exhibited typical characteristics of Apiaceae and were relatively conserved. Several SSR loci, highly divergent regions, and potential genetic markers were discovered in the chloroplast genomes. Phylogenomic analysis based on whole chloroplast genome sequences strongly supported the monophyly of Sium and the sister relationship of its two inclusive clades.
Article
Thermodynamics
J. Sathish Kumar, G. Senthilkumar, S. Ramachandran
Summary: The research aims to address the issue of poor thermal conductivity caused by the spherical form of CuO nanoparticles by using polyhedral-shaped MgO nanoparticles. The study introduces a novel approach of adding MgO nanoparticles to improve thermal conductivity and provides experimental data to support this strategy.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Biotechnology & Applied Microbiology
Aura Maria Moreno-Echeverri, Eva Susnik, Dimitri Vanhecke, Patricia Taladriz-Blanco, Sandor Balog, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: This study provides detailed experiments on the dynamics of nanoparticles in cells and discusses potential biases and solutions. The results present the correlation parameters for nanoparticle co-localization with lysosomes, showing that the co-localization results can vary depending on different experimental setups.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Optics
Sarah Morais Bezerra, Viktoria Levchenko, Fabio Piccinelli, Marco Bettinelli, Ricardo Luiz Longo, Oscar Loureiro Malta, Renata Reisfeld
Summary: A theoretical model based on rate equations and energy transfer rates was developed to explain a threefold increase in the photoluminescence of a Eu(III)-pyridine complex in the presence of copper nanoparticles (CuNPs). The model was modified and generalized to describe the interactions between copper oxide nanoparticles (CuONPs) and the Eu(III) complex, as well as simultaneous interactions of CuNPs and CuONPs with the Eu(III) complex.
JOURNAL OF LUMINESCENCE
(2022)
Article
Chemistry, Analytical
Ilaria Sorrentino, Marie Carriere, Helene Jamet, Ilaria Stanzione, Alessandra Piscitelli, Paola Giardina, Alan Le Goff
Summary: We investigated the use of POXA1b laccase from Pleurotus ostreatus for the oxidation of anthracene into anthraquinone. Different pathways can occur depending on the redox mediator combined to laccase, leading to different isomers. Carbon nanotubes were shown to act as redox mediators for anthracene oxidation into 9,10-anthraquinone, which was corroborated by theoretical calculations. The efficient adsorption of anthraquinones at CNT electrodes allows for low limit-of-detection of anthracene using laccase in solution, CNT-supported laccase, or laccase immobilized at magnetic beads.
Article
Chemistry, Multidisciplinary
Paulo Henrique M. Buzzetti, Marie Carriere, Monica Brachi, Karine Gorgy, Muhammad Mumtaz, Redouane Borsali, Serge Cosnier
Summary: Glyconanoparticles (GNPs) were prepared using a carbohydrate-based polystyrene-block-beta-cyclodextrin copolymer and used as a building block for nanostructured biomaterials of electrodes. The immobilization of GNPs on electrochemically generated polymer and copolymer was achieved through host-guest interactions. The specific anchoring ability of GNPs for biological macromolecules was investigated using glucose oxidase enzyme modified by adamantane groups. The immobilized enzyme showed excellent performance for the electro-oxidation of H2O2 generated by glucose in aqueous solution. The study demonstrates the importance of GNPs in the design of efficient bioelectrodes.
Article
Biochemical Research Methods
Caroline Bissardon, Xacier Mermet, Clement Quintard, Federico Sanjuan, Yves Fouillet, Frederic Bottausci, Marie Carriere, Florence Rivera, Pierre Blandin
Summary: In this article, the authors present an original selective plane illumination fluorescence microscope that is dedicated to imaging biostructures similar to organ-on-chips in microfluidic chips. The microscope compromises between a relatively large field of view and moderate resolution to allow morphological analysis of volumetric samples at the cellular scale inside microfluidic chambers. The setup is based on a simple design built around the chip and its microfluidic environment, enabling 3D imaging inside the chip.
BIOMEDICAL OPTICS EXPRESS
(2022)
Review
Toxicology
Ozge Kose, Paride Mantecca, Anna Costa, Marie Carriere
Summary: This study constructed a putative AOPs related to reproductive toxicity of Ag NPs, identifying a series of key events including ROS accumulation, mitochondrial damage, DNA damage and lipid peroxidation, apoptosis, reduced production of reproductive hormones, and reduced quality of sperm, which may lead to impaired male fertility.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Nienke Ruijter, Lya G. Soeteman-Hernandez, Marie Carriere, Matthew Boyles, Polly McLean, Julia Catalan, Alberto Katsumiti, Joan Cabellos, Camilla Delpivo, Araceli Sanchez Jimenez, Ana Candalija, Isabel Rodriguez-Llopis, Socorro Vazquez-Campos, Flemming R. Cassee, Hedwig Braakhuis
Summary: The Safe-by-Design (SbD) concept aims to enhance the development of safer materials/products by reducing hazards and exposures through timely interventions. This review evaluates commonly used in vitro assays for their suitability in SbD hazard testing of nanomaterials (NMs). It also discusses the effects of various factors on predictivity and the compatibility of assays with advanced materials and NMs released during the lifecycle.
Article
Biochemistry & Molecular Biology
Marie Carriere, Paulo Henrique M. Buzzetti, Karine Gorgy, Fabien Giroud, Hong Li, Redouane Borsali, Serge Cosnier
Summary: This study presents the design and characterization of novel electrode materials composed of multi-walled carbon nanotubes coated with glyconanoparticles functionalized with anthraquinone sulfonate. The modified electrodes were analyzed using scanning electron microscopy and cyclic voltammetry. The electrochemical behavior exhibited a stable pH-dependent redox signal specific to anthraquinone sulfonate. Immobilizing bilirubin oxidase onto these three-dimensional electrodes resulted in the electroenzymatic reduction of O2 to water with an onset potential of 0.5 V/SCE. A catalytic cathodic current of 174 µA (0.88 mA cm-2) at 0.1 V/SCE demonstrated that glyconanoparticles modified with anthraquinone sulfonate facilitated the interaction and orientation of bilirubin oxidase through electrostatic interactions.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Physical
Nadja Groysbeck, Victor Hanss, Mariel Donzeau, Jean-Marc Strub, Sarah Cianferani, Daniele Spehner, Mounib Bahri, Ovidiu Ersen, Mikhael Eltsov, Patrick Schultz, Guy Zuber
Summary: Advances in cryo-electron microscopy have allowed for near-native imaging of protein assemblies within mammalian cells. Gold nanoparticles have been synthesized and functionalized to bind to specific intracellular targets and be detected in vitreous sections. Cryo-EM of vitreous cell sections demonstrates the presence of these biofunctionalized gold nanoparticles in the nucleus, making them powerful labeling tools for cellular cryo-EM.
Article
Environmental Sciences
Giulia Motta, Maurizio Gualtieri, Melissa Saibene, Rossella Bengalli, Andrea Brigliadori, Marie Carriere, Paride Mantecca
Summary: In this study, two newly developed silver nanoparticles coated with hydroxyethyl cellulose were tested and compared to reference nanoparticles. The results showed a different toxicity pattern, with the hydroxyethyl cellulose-coated nanoparticles exhibiting lower toxicity and potential for further development.
Article
Nanoscience & Nanotechnology
Irini Furxhi, Rossella Bengalli, Giulia Motta, Paride Mantecca, Ozge Kose, Marie Carriere, Ehtsham Ul Haq, Charlie O'Mahony, Magda Blosi, Davide Gardini, Anna Costa
Summary: In this study, we developed quantitative structure-activity relationship models based on nanoscale features and biological attributes to predict hazard classes. We also obtained interpretable rules using a Bayesian network structure to consider safety aspects during the synthesis stage. This study reveals the importance of quantitative intrinsic hazard criteria and discusses the challenges and future directions for their generation and implementation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Vincent Piou, Caroline Vilarem, Solene Blanchard, Jean-Marc Strub, Fabrice Bertile, Michel Bocquet, Karim Arafah, Philippe Bulet, Angelique Vetillard
Summary: Varroa destructor is a widespread parasite that damages Western honey bee colonies. The parasite feeds on various developmental stages of the bees, but its exact diet and nutritional requirements are poorly understood. In a study, researchers found that the parasite could survive on different diets for several days or weeks, with bee larval hemolymph supporting the highest survival rates. Proteomic analysis also identified key energy metabolism proteins in larval honey bee plasma that may be crucial for the parasite's survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Environmental Sciences
Maurizio Gualtieri, Marie Carriere, Paride Mantecca
Article
Automation & Control Systems
Svetlana Ponomareva, Marie Carriere, Yanxia Hou, Robert Morel, Bernard Dieny, Helene Joisten
Summary: In the field of mechanobiology, artificial mechano-reactive systems are crucial for generating mechanical forces and controlling material deformations. Magnetic nanoparticles and composite materials have been used for mechanical stimulation of living cells and mimicking muscles. This study focuses on a new magnetically actuated membrane, which has potential applications in soft robotics and bioreactors.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Ana Peropadre, Patricia Vega-Cuesta, Paloma Fernandez Freire, Diego Pulido, Marie Carriere, Jose F. F. de Celis
Summary: This study analyzed the effects of two nano-enabled food additives, silicon dioxide E551 and titanium dioxide E171, on Drosophila melanogaster intestines and two human cell lines of intestinal origin. The results showed that these compounds had minimal cytotoxic effects on cells and organisms, but caused changes in the expression levels of certain genes.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Florian Vanneste, Allison Faure, Mathieu Varache, Mario Menendez-Miranda, Virginie Dyon-Tafani, Sebastien Dussurgey, Elisabeth Errazuriz-Cerda, Veronica La Padula, Pierre Alcouffe, Marie Carriere, Ruxandra Gref, Frederic Laurent, Jerome Josse, Catherine Ladaviere
Summary: LipoParticles, core-shell assemblies consisting of a polymer core coated by a lipid membrane, show enhanced internalization in osteoblast cells compared to PLGA particles. This was confirmed through observations with a confocal laser scanning microscope and flow cytometry assays. TEM analysis also revealed the localization of LipoParticles close to intracellular Staphylococcus aureus.
Article
Chemistry, Multidisciplinary
Svetlana Ponomareva, Helene Joisten, Taina Francois, Cecile Naud, Robert Morel, Yanxia Hou, Thomas Myers, Isabelle Joumard, Bernard Dieny, Marie Carriere
Summary: This study presents a new approach to induce insulin release from beta-islet pancreatic cells by mechanical stimulation. The researchers used magnetic particles and magnetic fields to stimulate the cells, and measured insulin release to evaluate the cell response. The results demonstrated that mechanical action is an efficient stimulus for insulin secretion, potentially allowing for the design of a system that triggers insulin secretion on demand.
