Article
Pharmacology & Pharmacy
Marc Lopez-Cano, Joan Font, Ester Aso, Kristoffer Sahlholm, Gisela Cabre, Jesus Giraldo, Yves De Koninck, Jordi Hernando, Amadeu Llebaria, Victor Fernandez-Duenas, Francisco Ciruela
Summary: Photopharmacology offers a promising approach to improve the benefit/risk profiles of opioid-based drugs. This study successfully developed a morphine photo-derivative that can be activated by light, providing effective analgesia without the occurrence of tolerance or associated opioid-related side effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neuroimaging
Sarah L. Withey, Lei Cao, Fernando B. de Moura, Kenroy R. Cayetano, Michael L. Rohan, Jack Bergman, Stephen J. Kohut
Summary: This study used functional magnetic resonance imaging (fMRI) to investigate the effects of fentanyl on brain activation patterns in awake nonhuman primates. The results showed that fentanyl inhibited brain regions involved in the behavioral effects of opioid agonists and altered functional connectivity in the cortico-striatal-thalamo-cortical (CSTC) circuit. These findings are important for understanding the neural mechanisms of opioid use disorder and finding effective treatments for drug-induced dysregulation.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Chemistry, Medicinal
Peng-Cheng Yu, Cui-Yun Hao, Ying-Zhe Fan, Di Liu, Yi-Fan Qiao, Jia-Bao Yao, Chang-Zhu Li, Ye Yu
Summary: Morphine, an effective analgesic, may cause immunosuppression and increased susceptibility to infection and tumor metastatic recurrence. The mechanisms and clinical strategies to alleviate this suppression need further investigation.
Review
Biochemistry & Molecular Biology
Morteza Abyadeh, Vivek Gupta, Joao A. Paulo, Veer Gupta, Nitin Chitranshi, Angela Godinez, Danit Saks, Mafruha Hasan, Ardeshir Amirkhani, Matthew McKay, Ghasem H. Salekdeh, Paul A. Haynes, Stuart L. Graham, Mehdi Mirzaei
Summary: This review discusses the therapeutic properties of cannabinoids found in cannabis for various diseases and the need for more research to understand the molecular and biochemical effects of cannabis at a cellular level. Proteomics technology is highlighted as an efficient tool to study the mechanistic effects of cannabis on the human body, drawing conclusions about its toxicity, therapeutic benefits, safety, and efficacy profiles.
Article
Neurosciences
Nakul Aggarwal, Jonathan A. Oler, Do P. M. Tromp, Patrick H. Roseboom, Marissa K. Riedel, Victoria R. Elam, Melissa A. Brotman, Ned H. Kalin
Summary: Myelination is important for neuronal communication, and changes in white matter microstructure are associated with psychiatric disorders, including anxiety. Recent studies in rodents suggest that muscarinic antagonists can enhance myelination and improve behavior, but the effects of muscarinic antagonists on non-human primates have not been studied. This study investigates the effects of the muscarinic receptor antagonist solifenacin on anxious behaviors and white matter microstructure in preadolescent rhesus macaques.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
F. Munoz, A. Meaney, A. Gross, K. Liu, A. N. Pouliopoulos, D. Liu, E. E. Konofagou, V. P. Ferrera
Summary: The study shows that applying transcranial focused ultrasound (FUS) to the dorsal striatum can have positive effects on motivation and decision accuracy in nonhuman primates. This suggests the therapeutic potential of FUS in treating various human neural diseases, making it a promising technique for non-invasive deep brain stimulation.
Article
Engineering, Environmental
I. Brandts, C. Barria, M. A. Martins, L. Franco-Martinez, A. Barreto, A. Tvarijonaviciute, L. Tort, M. Oliveira, M. Teles
Summary: This study evaluated the short-term exposure of 45 nm PMMANPs on gilthead seabream by analyzing biomarkers in liver and plasma. The results showed an up-regulation of genes associated with lipid metabolism, an increase in cholesterol and triglycerides in plasma, and activation of antioxidant defenses. After 96 hours, the antioxidant capacity decreased and genotoxicity in blood cells was observed.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Yunhan Jiang, Ying Liu, Jian Zhang
Summary: Mixed antibiotics can stimulate the growth and microcystin synthesis of Microcystis aeruginosa by activating photosynthesis, carbon metabolism, and other pathways to enhance resistance to oxidative stress. This study provides insights into the mechanisms underlying the hormetic stimulation of harmful cyanobacterial blooms by antibiotic contaminants.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Immunology
Mizhou Hui, Xiaoxiao Jia, Xinrong Li, Rayko Lazcano-Silveira, Ming Shi
Summary: This study investigated the delivery of liposoluble C60 to human organs, tissues, and cells through blood, extracellular fluid, and cell culture fluid, and its anti-inflammatory and antioxidant effects. The results showed that liposoluble C60 effectively produced anti-inflammatory and antioxidant effects in hydrophilic media.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Vijay K. Singh, Alana D. Carpenter, Brianna L. Janocha, Sarah A. Petrus, Oluseyi O. Fatanmi, Stephen Y. Wise, Thomas M. Seed
Summary: Animal models are crucial for developing radiation medical countermeasures. Nonhuman primates play a significant role in obtaining regulatory approval for such agents. It is important to thoroughly characterize these animal models.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Editorial Material
Zoology
Carol A. Shively, Agnes Lacreuse, Brett M. Frye, Emily S. Rothwell, Manuel Moro
Summary: Aging across the Primate Order is poorly understood due to the lack of aged animals available for study and the difficulty in conducting longitudinal studies in long-lived species. The human population is rapidly aging, leading to an increase in chronic diseases and conditions impacting healthspan. Nonhuman primate models are crucial for understanding aging in the primate CNS, with similarities and differences to human aging being considered.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Review
Engineering, Biomedical
Thayssa Gomes da Silva, Rickson Souza Ribeiro, Andre Luiz Mencalha, Adenilson de Souza Fonseca
Summary: Researchers have been investigating the biological effects of non-ionizing radiation from low-power lasers since Endre Mester's results were reported. With the use of LEDs, photobiomodulation (PBM) has emerged. However, the molecular, cellular, and systemic effects of PBM are still being researched, and understanding them better could enhance clinical safety and efficacy.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Magdalena Zimon, Yunfeng Huang, Anthi Trasta, Aliaksandr Halavatyi, Jimmy Z. Liu, Chia-Yen Chen, Peter Blattmann, Bernd Klaus, Christopher D. Whelan, David Sexton, Sally John, Wolfgang Huber, Ellen A. Tsai, Rainer Pepperkok, Heiko Runz
Summary: Studying the contribution of pairs of genes to complex traits has been challenging. Here, the authors combine exome and genotype data with RNAi to screen for genetic interactions between 30 genes identified in lipid GWAS to hint at pairs whose joint modulation may improve lipid-lowering therapies.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Chengqian Huo, Qiang Zhao, Rutao Liu, Xiangxiang Li, Falin He, Mingyang Jing, Jingqiang Wan, Wansong Zong
Summary: This study systematically evaluated the toxic effects and mechanisms of indene (IND) on earthworm coelomocytes, focusing on the changes in oxidative balance and the activities of antioxidant enzymes. The results showed that IND disrupted the redox balance, inhibited antioxidant system activities, caused lipid peroxidation and membrane changes, and decreased cell viability. At the molecular level, IND bound to superoxide dismutase (SOD), changing its secondary structure and enhancing its activity. This research provides a scientific basis for the evaluation of IND toxicity.
Review
Biochemistry & Molecular Biology
Tomoshige Kino, Irina Burd, James H. Segars
Summary: The novel coronavirus disease COVID-19 has had a significant impact on human society, with the glucocorticoid dexamethasone identified as an effective treatment. Researchers suggest that SARS-CoV-2 infection may result in infected cell-specific glucocorticoid insensitivity, which makes dexamethasone effective for COVID-19 but harmful for other infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Lian Yi, Chia-Feng Tsai, Ercument Dirice, Adam C. Swensen, Jing Chen, Tujin Shi, Marina A. Gritsenko, Rosalie K. Chu, Paul D. Piehowski, Richard D. Smith, Karin D. Rodland, Mark A. Atkinson, Clayton E. Mathews, Rohit N. Kulkarni, Tao Liu, Wei-Jun Qian
ANALYTICAL CHEMISTRY
(2019)
Article
Biochemical Research Methods
Chia-Feng Tsai, Rui Zhao, Sarah M. Williams, Ronald J. Moore, Kendall Schultz, William B. Chrisler, Ljiljana Pasa-Tolic, Karin D. Rodland, Richard D. Smith, Tujin Shi, Ying Zhu, Tao Liu
MOLECULAR & CELLULAR PROTEOMICS
(2020)
Article
Chemistry, Analytical
Gabe Nagy, Isaac K. Attah, Christopher R. Conant, Weijing Liu, Sandilya V. B. Garimella, Harsha P. Gunawardena, Jared B. Shaw, Richard D. Smith, Yehia M. Ibrahim
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Piliang Xiang, Ying Zhu, Yu Yang, Zhitao Zhao, Sarah M. Williams, Ronald J. Moore, Ryan T. Kelly, Richard D. Smith, Shaorong Liu
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Adam L. Hollerbach, Ailin Li, Aneesh Prabhakaran, Gabe Nagy, Christopher P. Harrilal, Christopher R. Conant, Randolph Norheim, Colby E. Schimelfenig, Gordon A. Anderson, Sandilya V. B. Garimella, Richard D. Smith, Yehia M. Ibrahim
ANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Jacob Kagan, Robert L. Moritz, Richard Mazurchuk, Je Hyuk Lee, Peter Vasili Kharchenko, Orit Rozenblatt-Rosen, Eytan Ruppin, Fredrik Edfors, Fiona Ginty, Yury Goltsev, James A. Wells, John LaCava, Jessica L. Riesterer, Ronald N. Germain, Tujin Shi, Mark S. Chee, Bogdan A. Budnik, John R. Yates, Brian T. Chait, Jeffery R. Moffitt, Richard D. Smith, Sudhir Srivastava
JOURNAL OF PROTEOME RESEARCH
(2020)
Article
Oncology
Yuqian Gao, Yi-Ting Wang, Yongmei Chen, Hui Wang, Denise Young, Tujin Shi, Yingjie Song, Athena A. Schepmoes, Claire Kuo, Thomas L. Fillmore, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, Albert Dobi, Isabell A. Sesterhenn, Inger L. Rosner, Gyorgy Petrovics, Karin D. Rodland, Shiv Srivastava, Jennifer Cullen, Tao Liu
Article
Chemistry, Analytical
Sarah M. Williams, Andrey Liyu, Chia-Feng Tsai, Ronald J. Moore, Daniel J. Orton, William B. Chrisler, Matthew J. Gaffrey, Tao Liu, Richard D. Smith, Ryan T. Kelly, Ljiljana Pasa-Tolic, Ying Zhu
ANALYTICAL CHEMISTRY
(2020)
Article
Cell Biology
Eric S. Orwoll, Jack Wiedrick, Carrie M. Nielson, Jon Jacobs, Erin S. Baker, Paul Piehowski, Vladislav Petyuk, Yuqian Gao, Tujin Shi, Richard D. Smith, Douglas C. Bauer, Steven R. Cummings, Jodi Lapidus
Article
Biochemical Research Methods
Christopher R. Conant, Isaac K. Attah, Sandilya V. B. Garimella, Gabe Nagy, Aivett Bilbao, Richard D. Smith, Yehia M. Ibrahim
Summary: In this study, five different waveforms were characterized in terms of their transmission efficiency, IMS resolution, and resolving power, with triangle and asymmetric ramp profiles found to offer modestly greater resolution and resolving power compared to others. The research also revealed that separations were generally improved with higher TW amplitudes, moderately improved by lower speeds, but experienced decreases in signal intensity under extreme operating conditions.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2021)
Article
Chemistry, Analytical
Ailin Li, Gabe Nagy, Christopher R. Conant, Randolph Norheim, Joon Yong Lee, Cameron Giberson, Adam L. Hollerbach, Venkateshkumar Prabhakaran, Isaac K. Attah, Christopher D. Chouinard, Aneesh Prabhakaran, Richard D. Smith, Yehia M. Ibrahim, Sandilya V. B. Garimella
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Ailin Li, Christopher R. Conant, Xueyun Zheng, Kent J. Bloodsworth, Daniel J. Orton, Sandilya V. B. Garimella, Isaac K. Attah, Gabe Nagy, Richard D. Smith, Yehia M. Ibrahim
ANALYTICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Kendall Martin, Tong Zhang, Pengfei Zhang, William B. Chrisler, Fillmore L. Thomas, Fen Liu, Tao Liu, Wei-Jun Qian, Richard D. Smith, Tujin Shi
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Mathematical & Computational Biology
Yuping Zhang, Zhengqing Ouyang, Wei-Jun Qian, Richard D. Smith, Wing Hung Wong, Ronald W. Davis
STATISTICS AND ITS INTERFACE
(2020)
Article
Chemistry, Multidisciplinary
Gabe Nagy, Dusan Velickovic, Rosalie K. Chu, Alyssa A. Carrell, David J. Weston, Yehia M. Ibrahim, Christopher R. Anderton, Richard D. Smith
CHEMICAL COMMUNICATIONS
(2019)